Science
Introduction
Faire progresser l’immunologie ensemble
Le Centre d’Immunologie de Marseille-Luminy (CIML) regroupe 16 équipes de recherche couvrant l’ensemble des champs de l’immunologie moderne, de la biologie moléculaire aux applications thérapeutiques. Cette diversité permet au CIML d’aborder les questions immunologiques fondamentales tout en développant des approches translationnelles pour la santé humaine, positionnant notre institut comme un acteur majeur de la recherche en immunologie en France et en Europe.
Les équipes du CIML développent une approche globale de l’immunologie, alliant l’étude des mécanismes moléculaires de reconnaissance et de signalisation cellulaire aux interactions complexes entre cellules immunitaires dans différents tissus. Les recherches s’étendent des processus de développement et de différenciation du système immunitaire jusqu’aux dysfonctionnements pathologiques, notamment dans le contexte des infections, de l’inflammation et des cancers.
INNATE IMMUNITY
L’immunité innée constitue un des axes majeurs de la recherche au CIML avec des équipes dédiées à la compréhension des premières lignes de défense. Ces recherches couvrent la biologie des cellules dendritiques et leur rôle dans la défense antivirale, l’immunobiologie de l’inflammation, les cellules lymphoïdes innées, l’immunité au niveau des muqueuses, le développement du système immunitaire, l’immunosurveillance du système nerveux central, la régulation neuronale de l’immunité, et l’immunologie des cellules stromales.
ADAPTIVE IMMUNITY
L’immunité adaptative constitue l’autre axe majeur de la recherche au CIML avec des équipes explorant les mécanismes spécialisés de reconnaissance et de mémoire immunitaire. Ces recherches incluent la signalisation et la dynamique membranaire des lymphocytes T, la biologie intégrative des lymphocytes B et T, les mécanismes de tolérance immunitaire, l’immunité B contre les infections, l’analyse des répertoires adaptatifs, et la pathogenèse des néoplasies lymphoïdes.
This multi-scale and interdisciplinary approach allows for an in-depth understanding of immune responses and opens the way to new therapeutic strategies in human health.
Teams
Projects
Project: UNFIRE Other participants: Ciphe (Ana Zarubica), Hospices Civils de Lyon and CIRI (Sophie Trouillet-Assant, Thierry Walzer), CoVir team […]
The AITLas-Impact project, coordinated by Pierre Milpied (CIML) in collaboration with Professor François Lemonnier (Mondor Institute of Biomedical Research, […]
Project: REVOLUTION Coordinator: Edouard Sage, Foch Hospital, Suresnes. Other partners: Isabelle Schwartz-Cornil, INRAE, Jouy-en-Josas; Jérémie Pourchez, Ecole des Mines […]
The ANTIBAX project, funded by the France 2030 “Health Impact” program, aims to develop therapeutic antibodies targeting bacteria […]
Full title & acronym: Biomarkers established to stratify sepsis long-term adverse effects to improve patients' survivorship (BEATsep).Duration: 2024–2029 (60 months).Partners […]
Project: CARCINOMAC Head and neck cancers are the sixth most common type of cancer. Among these, the Oral Squamous […]
Project: ThymMap T lymphocytes recognize pathogens while being tolerant to our tissues. They differentiate […]
Our health depends on a delicate balance between immune defense against pathogens and tolerance to […]
L’équipe du Dr Pierre Milpied au CIML participe à un projet collaboratif coordonné par le Dr Jean-Pierre de Villartay (Institut […]
Project: PLBIO-25 Coordinator: Marianne BURBAGE, Institut Curie, Paris. Other participant: Andrew GRIFFITHS, ESPCI, Paris. The effectiveness of CD8 T lymphocytes […]
Amidex Project: ELNINo We analyze how neuronal signals integrate with immune and stromal programs to orchestrate ganglion organogenesis. In […]
The progression of follicular lymphoma is marked by iterative cycles of remission and relapse, the latter usually resulting from the […]
Projet: D2OX Le projet interdisciplinaire D2OX est divisé en trois tâches fortement interconnectées pour élucider comment l’efficacité des complexes OXPHOS […]
Project: NRegSkin Project leader: Mei LI (IGBMC, Strasbourg). Other participants: Katia Boniface, Julien Seneschal (University of Bordeaux). Summary: The skin […]
Project: MITI Other participants: Magali Richard, LIG, Grenoble; Lionel Spinelli, CB2M hub of CIML. Summary: This project aims to […]
Project: DECITIP Plasmacytoid dendritic cells (pDCs) excel in the production of type I and III interferons (IFN), […]
Project: PLBIO 2021 Coordinator: Christophe CAUX, CRCL, Lyon. Other participants: Alain Viari, Inria, Lyon; Nathalie Bendriss-Vermare, CRCL, Lyon. How […]
Project: ACLAMADABREC Partly through their effectiveness in activating natural killer (NK) cells and CD8 T lymphocytes […]
Project: EndoPos The EndoPos project explores the role of the GDPD2 enzyme, produced in particular by pulp fibroblasts […]
Duration: 2021–2025.Partners & funding amounts: APHM/La Timone (E. Tabouret); amount for team: 325 k€.Responsibilities: PI–coordinator (only beneficiary)Theme & content of […]
Project: T-ALL Leukemias T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer, representing 25% of […]
Project: HematoMaf Although hematopoietic stem cells (HSCs) have been used in cell therapy in humans for over 40 years, […]
The GCselection project, coordinated by Dr. Pierre Milpied (CIML), revisits the mechanisms of antibody maturation in centers […]
Project: HOMEOSTASIS HOMEOSTASIS explores how host–commensal interactions preserve tissue equilibrium. Using a model of long-term, inflammation-free oral colonization by […]
Project: HSC-Immunobiography My goal is to understand how inflammatory stresses encountered during an individual's life […]
In order to identify new therapeutic combinations and understand the mechanisms of resistance to targeted therapies in lymphoid-derived hemopathies […]
Targeting intratumor metabolic heterogeneity in neuroblastoma to develop innovative treatments (IMAGINe) Type: National.Duration: 2024–2029 (48 months).Partners & funding amounts: CRCM […]
Nerve fibers are increasingly emerging as key players in the tumor microenvironment, capable of modulating […]
Project: CureMAC This Franco-German research project, coordinated by Sandrine Sarrazin, combines the expertise of her group with that of the teams […]
Project: ICARO Current acellular vaccines are mostly effective against extracellular pathogens, but fail to induce a response […]
Project: IMPACT Sensors Other participants: IGBMC, Strasbourg (Nicolas Charlet-Berguerand) and Institut Curie, Paris (Franck Perez). Duration 2025 – […]
Project: PIONeeR Lung cancer is the leading cause of cancer death, with more than 1.5 million […]
Project: SelfExpress The thymus plays a critical role in establishing central tolerance by producing a diverse repertoire […]
Projet : LINkS Le projet LINkS (EU FET-OPEN) vise à changer les paradigmes de l’auto-organisation de la matière vivante intracellulaire, […]
The University Hospital Research (RHU) project LUCA-pi (Lung Cancer prevention and interception), coordinated by Professor David Boulate (AP-HM), aims […]
Project: LYMPHOMATLAS Single-cell multi-omic studies in B-lymphomas have highlighted a […]
CNRS – University of Melbourne Graduate Research Projects The project investigates the molecular interplay between the E3-ubiquitin ligase MARCH1 and […]
Bone marrow metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02). Duration: 2023–2027 (42 months).Partners & funding amounts: Institut Curie (L. Perié), Institut […]
Project: Myfunbat The project aims to define the diversity and functions of brown adipose tissue (BAT) macrophages, […]
Au delà des processus de perception de la douleur qui sont induits en cas de lésion ou d’infection de la […]
Project: NICHE The NICHE project explores the concept that macrophages (Macs) depend on local niches formed by […]
Project: Path Finder This project aims to characterize the spatio-temporal development of type I dendritic cells (cDC1) in […]
The PLAIR project, coordinated by Dr Amédée Renand (CR2TI, Nantes), aims to identify the molecular pathways controlling the response […]
We have demonstrated that the neurokine TAFA4, produced by sensory neurons in the skin, can promote tissue repair […]
Project: T2DRGMacPain Obesity is a major factor in metabolic disorders such as type 2 diabetes. Dysfunction of […]
Les macrophages résidents des tissus jouent un rôle fondamental dans l’homéostasie tissulaire et sa régénération après lésion. Dans un modèle […]
La réponse de l’hôte aux pathogènes est orchestrée par le système immunitaire et le système nerveux, tous deux présents dans […]
Project: PPTuft This project coordinated by Philippe Jay (IGF, Montpellier) in partnership with our team aims to determine the […]
Projet: DECODIS Les méninges abritent plusieurs populations de cellules immunitaires capables d’influencer directement l’activité du cerveau, en particulier lorsqu’un événement […]
Project: pDCComp Individuals infected with viruses or suffering from inflammatory diseases develop a set of behavioral disorders […]
Project: PLBIO 2024 Coordinator: Thierry Walzer, CIRI, Lyon. Other participant: Nathalie Bendriss-Vermare, CRCL, Lyon. Abstract: Natural Killer cells […]
Project: RIPIREVI Other participants: CIPHE (Ana Zarubica and colleagues). Abstract: Type I interferons (IFN-Is) are essential for […]
Project : BAMneuro ERC Consolidator Le cerveau adulte reste extraordinairement plastique et cette adaptabilité dépend en partie des interactions continues […]
INCA TUMC21-019 Le méningiome, l’une des tumeurs cérébrales les plus fréquentes, se développe au contact direct des méninges, un environnement […]
Projet: NANNYMACBRAIN Le développement du cerveau dépend d’un échange continu entre cellules immunitaires frontalières et réseaux neuronaux en formation. Nous […]
Projet: CNSentinels ERC Starting Les infections virales touchant le système nerveux peuvent provoquer des altérations majeures des fonctions cérébrales. Ce […]
Project: DeCoDis In the context of a European consortium, we are investigating the dynamics and function of border-associated macrophages […]
Project: Reality Foxp3+ regulatory T cells (Tregs) are crucial players in the control of autoimmune and inflammatory diseases […]
Project: SensoSkin Apical extracellular matrix (aECM) shapes and protects the epithelium in all organisms. We previously showed that like […]
South-Research On Cancer for Kids. INCA Pediacriex (France) Type: National (integrated cancer site).Full title & acronym: South-Research On Cancer for […]
L’action structurante Spatial Omics du consortium CALYM, coordonnée par le Dr Pierre Milpied, vise à développer une plateforme virtuelle dédiée […]
L’action structurante ST-omics du Cancéropôle de la Région Sud est co-coordonnée par le Dr Pierre Milpied (CIML), le Pr Emmanuelle […]
Project: T-MAC The T-MAC project aims to understand how testicular macrophages and their niches contribute to the maintenance of […]
Targeting acute myeloid leukemia immunosuppressive microenvironment by combined IDO1 inhibition and PD-1 blockade Type: European.Duration: 2023–2027 (36 months).Partners & funding […]
The TCELL-CODE project, coordinated by Dr. Rémy Lasserre at the Marseille Cancer Research Center, aims to elucidate […]
Project: CholControl You are what your mother ate Transgenerational impact of maternal diets via the regulation of RORγt activity […]
Acronym: TollSOME Obesity is a global health challenge linked to diabetes, hypertension, and cardiovascular disease. While it often stems from […]
Project: Treating Breast Cancer Breast cancer is the most frequently diagnosed cancer in women in […]
Project: TREATLIVMETS Liver metastases occur in nearly 50% of cancer patients, particularly in […]
Project: INTERMUCOSAL This project explores the role of an immune system molecule called type III interferon (IFN-λ). This […]
The integrated stress response (ISR) is a cellular pathway activated by various biochemical triggers. It reduces global protein synthesis while […]
Project: DCFUNDEVSCREEN Abstract: Studies in mice have shown the key antiviral/tumor role of plasmacytoid dendritic cells (pDCs) […]
Full title & acronym: Understanding lipid immunometabolism to treat disease (UNLIMITED).Duration: 2025–2029 (48 months).Partners & funding amounts: Consortium led by […]