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The Center for Immunology of Marseille-Luminy (CIML) – Advancing immunology together

Founded in 1976, the CIML is an internationally renowned research center dedicated to the study of the immune system in all its diversity. Under the joint supervision of Aix-Marseille University, the CNRS, and Inserm, our institute embodies nearly 50 years of scientific excellence and innovation in immunology.

Latest Publications
2025
Ngo C, Pierini-Malosse C, Rahmani K, Valente M, Collinet N, Bessou G, Guerry C, Fabregue M, Mathieu …, Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections., Nat Immunol 2025 Sep; (): .
2025
Wang X, Li J, Rebuffet L, Cheng M, Bao B, Chen Y, Zheng X, Chen Y, Sun H, Sun R, Vivier E, Peng H, T…, Innate lymphoid cells originate from fetal liver-derived tissue-resident progenitors., Sci Immunol 2025 Jul; 10(109): eadu7962.
2025
Mailfert S, Djendli M, Fabre R, Marguet D, Bertaux N, Quality control maps: Real-time quantitative control of single-molecule localization microscopy data., Biophys J 2025 Apr; 124(7): 1132-1145.
2024
Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenou…, Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair., Cell 2024 Dec; 187(26): 7533-7550.e23.
2024
Santamaria JC, Chevallier J, Dutour L, Picart A, Kergaravat C, Cieslak A, Amrane M, Vincentelli R, P…, RANKL treatment restores thymic function and improves T cell-mediated immune responses in aged mice., Sci Transl Med 2024 Dec; 16(776): eadp3171.
2024
Borelli A, Santamaria JC, Zamit C, Apert C, Chevallier J, Pierre P, Argüello RJ, Spinelli L, Irla M, Lymphotoxin limits Foxp3+ regulatory T cell development from Foxp3lo precursors via IL-4 signaling., Nat Common 2024 Aug; 15(1): 6976.
2024
Lucas Rebuffet, Janine E Melsen, Bertrand Escalière, Daniela Basurto-Lozada, Avinash Bhandoola, Nik…, High-dimensional single-cell analysis of human natural killer cell heterogeneity, <i>Nature Immunology</i>, 2024, 25 (8), pp.1474-1488. <a target="_blank" href="https://dx.doi.org/10.1038/s41590-024-01883-0">⟨10.1038/s41590-024-01883-0⟩</a>.