Science
Introduction
Advancing immunology together
The Center for Immunology of Marseille-Luminy (CIML) brings together 16 research teams covering all fields of modern immunology, from molecular biology to therapeutic applications. This diversity allows the CIML to address fundamental immunological questions while developing translational approaches for human health, positioning our institute as a major player in immunology research in France and Europe.
CIML teams are developing a comprehensive approach to immunology, combining the study of molecular mechanisms of cell recognition and signaling with the complex interactions between immune cells in different tissues. Research spans the development and differentiation processes of the immune system to pathological dysfunctions, particularly in the context of infections, inflammation, and cancer.
INNATE IMMUNITY
Innate immunity is a major focus of research at CIML, with teams dedicated to understanding the first lines of defense. This research covers the biology of dendritic cells and their role in antiviral defense, the immunobiology of inflammation, innate lymphoid cells, mucosal immunity, immune system development, central nervous system immunosurveillance, neuronal regulation of immunity, and stromal cell immunology.
ADAPTIVE IMMUNITY
Adaptive immunity is another major focus of research at CIML, with teams exploring specialized mechanisms of immune recognition and memory. This research includes T cell signaling and membrane dynamics, integrative B and T cell biology, immune tolerance mechanisms, B cell immunity to infections, analysis of adaptive repertoires, and the pathogenesis of lymphoid neoplasias.
This multi-scale and interdisciplinary approach allows for an in-depth understanding of immune responses and opens the way to new therapeutic strategies in human health.
Teams
Projects
Les macrophages résidents des tissus jouent un rôle fondamental dans l’homéostasie tissulaire et sa régénération après lésion. Dans un modèle […]
Beyond the pain perception processes that are induced in the event of injury or infection of the […]
Dr. Pierre Milpied's team at CIML is participating in a collaborative project coordinated by Dr. Jean-Pierre de Villartay (Institut […]
The AITLas-Impact project, coordinated by Pierre Milpied (CIML) in collaboration with Professor François Lemonnier (Mondor Institute of Biomedical Research, […]
The ST-omics structuring action of the Cancéropôle de la Région Sud is co-coordinated by Dr Pierre Milpied (CIML), Prof Emmanuelle […]
The GCselection project, coordinated by Dr. Pierre Milpied (CIML), revisits the mechanisms of antibody maturation in centers […]
The University Hospital Research (RHU) project LUCA-pi (Lung Cancer prevention and interception), coordinated by Professor David Boulate (AP-HM), aims […]
The structuring action Spatial Omics of the CALYM consortium, coordinated by Dr Pierre Milpied, aims to develop a virtual platform dedicated […]
The PLAIR project, coordinated by Dr Amédée Renand (CR2TI, Nantes), aims to identify the molecular pathways controlling the response […]
The TCELL-CODE project, coordinated by Dr. Rémy Lasserre at the Marseille Cancer Research Center, aims to elucidate […]
The ANTIBAX project, funded by the France 2030 “Health Impact” program, aims to develop therapeutic antibodies targeting bacteria […]
We have demonstrated that the neurokine TAFA4, produced by sensory neurons in the skin, can promote tissue repair […]
Targeting intratumor metabolic heterogeneity in neuroblastoma to develop innovative treatments (IMAGINe) Type: National.Duration: 2024–2029 (48 months).Partners & funding amounts: CRCM […]
South-Research On Cancer for Kids. INCA Pediacriex (France) Type: National (integrated cancer site).Full title & acronym: South-Research On Cancer for […]
Full title & acronym: Biomarkers established to stratify sepsis long-term adverse effects to improve patients' survivorship (BEATsep).Duration: 2024–2029 (60 months).Partners […]
Bone marrow metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02). Duration: 2023–2027 (42 months).Partners & funding amounts: Institut Curie (L. Perié), Institut […]
Duration: 2021–2025.Partners & funding amounts: APHM/La Timone (E. Tabouret); amount for team: 325 k€.Responsibilities: PI–coordinator (only beneficiary)Theme & content of […]
Full title & acronym: Understanding lipid immunometabolism to treat disease (UNLIMITED).Duration: 2025–2029 (48 months).Partners & funding amounts: Consortium led by […]
Targeting acute myeloid leukemia immunosuppressive microenvironment by combined IDO1 inhibition and PD-1 blockade Type: European.Duration: 2023–2027 (36 months).Partners & funding […]
CNRS – University of Melbourne Graduate Research Projects The project investigates the molecular interplay between the E3-ubiquitin ligase MARCH1 and […]
Project: SensoSkin Apical extracellular matrix (aECM) shapes and protects the epithelium in all organisms. We previously showed that like […]
Project: T2DRGMacPain Obesity is a major factor in metabolic disorders such as type 2 diabetes. Dysfunction of […]
Nerve fibers are increasingly emerging as key players in the tumor microenvironment, capable of modulating […]
The host response to pathogens is orchestrated by the immune system and the nervous system, both present in […]
Project: PPTuft This project coordinated by Philippe Jay (IGF, Montpellier) in partnership with our team aims to determine the […]
Project: HematoMaf Although hematopoietic stem cells (HSCs) have been used in cell therapy in humans for over 40 years, […]
Project: CureMAC This Franco-German research project, coordinated by Sandrine Sarrazin, combines the expertise of her group with that of the teams […]
The integrated stress response (ISR) is a cellular pathway activated by various biochemical triggers. It reduces global protein synthesis while […]
Project: EndoPos The EndoPos project explores the role of the GDPD2 enzyme, produced in particular by pulp fibroblasts […]
Project: T-MAC The T-MAC project aims to understand how testicular macrophages and their niches contribute to the maintenance of […]
Project: Path Finder This project aims to characterize the spatio-temporal development of type I dendritic cells (cDC1) in […]
Project: NICHE The NICHE project explores the concept that macrophages (Macs) depend on local niches formed by […]
Project: Myfunbat The project aims to define the diversity and functions of brown adipose tissue (BAT) macrophages, […]
In order to identify new therapeutic combinations and understand the mechanisms of resistance to targeted therapies in lymphoid-derived hemopathies […]
Project: LYMPHOMATLAS Single-cell multi-omic studies in B-lymphomas have highlighted a […]
The progression of follicular lymphoma is marked by iterative cycles of remission and relapse, the latter usually resulting from the […]
Project: HSC-Immunobiography My goal is to understand how inflammatory stresses encountered during an individual's life […]
Project: CARCINOMAC Head and neck cancers are the sixth most common type of cancer. Among these, the Oral Squamous […]
Project: HOMEOSTASIS HOMEOSTASIS explores how host–commensal interactions preserve tissue equilibrium. Using a model of long-term, inflammation-free oral colonization by […]
Project: CNSentinels Our research focuses on meningeal macrophages and their roles in health and disease. We found that meningeal […]
Project: DeCoDis In the context of a European consortium, we are investigating the dynamics and function of border-associated macrophages […]
Project: ICARO Current acellular vaccines are mostly effective against extracellular pathogens, but fail to induce a response […]
Project: INTERMUCOSAL This project explores the role of an immune system molecule called type III interferon (IFN-λ). This […]
Project: pDCComp Individuals infected with viruses or suffering from inflammatory diseases develop a set of behavioral disorders […]
Project: DECITIP Plasmacytoid dendritic cells (pDCs) excel in the production of type I and III interferons (IFN), […]
Project: ACLAMADABREC Partly through their effectiveness in activating natural killer (NK) cells and CD8 T lymphocytes […]
Project: PLBIO-25 Coordinator: Marianne BURBAGE, Institut Curie, Paris. Other participant: Andrew GRIFFITHS, ESPCI, Paris. The effectiveness of CD8 T lymphocytes […]
Project: PLBIO 2021 Coordinator: Christophe CAUX, CRCL, Lyon. Other participants: Alain Viari, Inria, Lyon; Nathalie Bendriss-Vermare, CRCL, Lyon. How […]
Project: REVOLUTION Coordinator: Edouard Sage, Foch Hospital, Suresnes. Other partners: Isabelle Schwartz-Cornil, INRAE, Jouy-en-Josas; Jérémie Pourchez, Ecole des Mines […]
Project: MITI Other participants: Magali Richard, LIG, Grenoble; Lionel Spinelli, CB2M hub of CIML. Summary: This project aims to […]
Project: PLBIO 2024 Coordinator: Thierry Walzer, CIRI, Lyon. Other participant: Nathalie Bendriss-Vermare, CRCL, Lyon. Abstract: Natural Killer cells […]
Project: UNFIRE Other participants: Ciphe (Ana Zarubica), Hospices Civils de Lyon and CIRI (Sophie Trouillet-Assant, Thierry Walzer), CoVir team […]
Project: DCFUNDEVSCREEN Abstract: Studies in mice have shown the key antiviral/tumor role of plasmacytoid dendritic cells (pDCs) […]
Project: NRegSkin Project leader: Mei LI (IGBMC, Strasbourg). Other participants: Katia Boniface, Julien Seneschal (University of Bordeaux). Summary: The skin […]
Project: RIPIREVI Other participants: CIPHE (Ana Zarubica and colleagues). Abstract: Type I interferons (IFN-Is) are essential for […]
Project: T-ALL Leukemias T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer, representing 25% of […]
Project: SelfExpress The thymus plays a critical role in establishing central tolerance by producing a diverse repertoire […]
Project: ThymMap T lymphocytes recognize pathogens while being tolerant to our tissues. They differentiate […]
Project: Reality Foxp3+ regulatory T cells (Tregs) are crucial players in the control of autoimmune and inflammatory diseases […]
Project: Treating Breast Cancer Breast cancer is the most frequently diagnosed cancer in women in […]
Project: PIONeeR Lung cancer is the leading cause of cancer death, with more than 1.5 million […]
Project: TREATLIVMETS Liver metastases occur in nearly 50% of cancer patients, particularly in […]
Project: D2OX The interdisciplinary D2OX project is divided into three highly interconnected tasks to elucidate how the efficiency of OXPHOS complexes […]
Project: LINkS The LINkS project (EU FET-OPEN) aims to change the paradigms of self-organization of intracellular living matter, […]
Project: CholControl You are what your mother ate Transgenerational impact of maternal diets via the regulation of RORγt activity […]
Project: IMPACT Sensors Other participants: IGBMC, Strasbourg (Nicolas Charlet-Berguerand) and Institut Curie, Paris (Franck Perez). Duration 2025 – […]
Amidex Project: ELNINo We analyze how neuronal signals integrate with immune and stromal programs to orchestrate ganglion organogenesis. In […]
Our health depends on a delicate balance between immune defense against pathogens and tolerance to […]