Thomas DUPIC – CIML

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Thomas Dupic a obtenu une thèse en physique théorique en 2018, où il a étudié des modèles de physique statistique. Il a ensuite rejoint le groupe d’Aleksandra Walczak et Thierry Mora au LPENS où il a étudié les statistiques du répertoire des lymphocytes T. Il a rejoint le groupe de Michael Desai, à Harvard, en tant que chercheur post-doctoral pour étudier les interactions entre protéines en haut-débit, notamment pour mieux comprendre l’évolution virale.

Depuis 2025, Thomas Dupic est responsable de l’équipe « Affinités dans le répertoire immunitaire », qui couple expérience haut-débit et méthodes computationnelles pour mieux comprendre contre quoi réagit le répertoire immunitaire.

Publications

Natanael Spisak, Gabriel Athens, Thomas Dupic, Thierry Mora, Aleksandra Walczak, Combining mutation and recombination statistics to infer clonal families in antibody repertoires, <i>eLife</i>, 2024, 13, pp.e86181. <a target="_blank" href="https://dx.doi.org/10.7554/eLife.86181">⟨10.7554/eLife.86181⟩</a>.

Abbate MF, Dupic T, Vigne E, Shahsavarian MA, Walczak AM, Mora T, Computational detection of antigen-specific B cell receptors following immunization. Proc Natl Acad Sci USA 2024 Aug; 121(35): e2401058121.

Dupic T, Phillips AM, Desai MM, Protein sequence landscapes are not so simple: on reference-free versus reference-based inference. bioRxiv 2024 Jan; (): .

Moulana A, Dupic T, Phillips AM, Desai MM, Genotype-phenotype landscapes for immune-pathogen coevolution. Trends Immunol 2023 May; 44(5): 384-396.

Moulana A, Dupic T, Phillips AM, Chang J, Roffler AA, Greaney AJ, Starr TN, Bloom JD, Desai MM, The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution., Elife 2023 Feb; 12(): .

Phillips AM, Maurer DP, Brooks C, Dupic T, Schmidt AG, Desai MM, Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody. Elife 2023 Jan; 12(): .

Moulana A, Dupic T, Phillips AM, Chang J, Nieves S, Roffler AA, Greaney AJ, Starr TN, Bloom JD, Desa..., Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1., Nat Common 2022 Nov; 13(1): 7011.

Phillips AM, Lawrence KR, Moulana A, Dupic T, Chang J, Johnson MS, Cvijovic I, Mora T, Walczak AM, D..., Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies. Elife 2021 Sep; 10(): .

Paul Gueguen, Christina Metoikidou, Thomas Dupic, Myriam Lawand, Christel Goudot, Sylvain Baulande, ..., Contribution of resident and circulating precursors to tumor-infiltrating CD8 + T cell populations in lung cancer, <i>Science Immunology</i>, 2021, 6 (55), pp.eabd5778. <a target="_blank" href="https://dx.doi.org/10.1126/sciimmunol.abd5778">⟨10.1126/sciimmunol.abd5778⟩</a>.

Dupic T, Bensouda Koraichi M, Minervina AA, Pogorelyy MV, Mora T, Walczak AM, Immune fingerprinting through repertoire similarity. PLoS Genet 2021 Jan; 17(1): e1009301.

Zachary Sethna, Giulio Isacchini, Thomas Dupic, Thierry Mora, Aleksandra Walczak, Yuval Elhanati, Population variability in the generation and thymic selection of T-cell repertoires, <i>PLoS Computational Biology</i>, 2020, 16 (12), pp.e1008394. <a target="_blank" href="https://dx.doi.org/10.1371/journal.pcbi.1008394">⟨10.1371/journal.pcbi.1008394⟩</a>.

Thomas Dupic, Quentin Marcou, Aleksandra M. Walczak, Thierry Mora, Genesis of the αβ T-cell receptor, <i>PLoS Computational Biology</i>, 2019, 15 (3), pp.e1006874. <a target="_blank" href="https://dx.doi.org/10.1371/journal.pcbi.1006874">⟨10.1371/journal.pcbi.1006874⟩</a>.