New immune cell engagers for cancer immunotherapy.

Published in: Nat Rev Immunol 2024 Jul; 24(7): 471-486

Authors: Fenis A, Demaria O, Gauthier L, Vivier E, Narni-Mancinelli E

Summary

There have been major advances in the immunotherapy of cancer in recent years, including the development of T cell engagers – antibodies engineered to redirect T cells to recognize and kill cancer cells – for the treatment of haematological malignancies. However, the field still faces several challenges to develop agents that are consistently effective in a majority of patients and cancer types, such as optimizing drug dose, overcoming treatment resistance and improving efficacy in solid tumours. A new generation of T cell-targeted molecules was developed to tackle these issues that are potentially more effective and safer. In addition, agents designed to engage the antitumour activities of other immune cells, including natural killer cells and myeloid cells, are showing promise and have the potential to treat a broader range of cancers.

Link to Pubmed [PMID] – 38273127

Link to DOI – 10.1038/s41577-023-00982-7