Publication: Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses.

Published in: Current Opinion in Immunology, 2007, 19 (3), pp.365-72. ⟨10.1016/j.coi.2007.04.004⟩

Authors: Thierry Walzer, Sébastien Jaeger, Julie Chaix, Eric Vivier

Summary

The original definition of NK cells was based on their ‘natural’ cytolytic response against tumor cells and virus-infected cells in the absence of specific immunization. However, the term ‘natural killer’ reflects neither the education/maturation requirements before NK cells can kill nor the entirety of their biological functions. In light of new functional assays, genetic models and genomics analysis, we propose a more accurate definition of NK cells. This definition includes the phenotypical identification of NK cells as CD3(-)NKp46(+) cells across mammalian species. In general, this attempt to redefine NK cells also highlights the need to update the operational definition of cell types in the post-genomic area.

Link to HAL – hal-00165529

Link to DOI – 10.1016/j.coi.2007.04.004