Publication: G-protein-coupled receptors in control of natural killer cell migration.

Published in: Trends in Immunology, 2011, epub ahead of print. ⟨10.1016/j.it.2011.05.002⟩

Authors: Thierry Walzer, Eric Vivier

Summary

Natural killer (NK) cells are highly motile cells that patrol lymphoid and non-lymphoid organs, and are poised to react to infectious or other inflammatory situations. Several NK cell subsets equipped with different sets of chemotactic G-protein-coupled receptors, and which display distinct distribution across lymphoid and non-lymphoid organs, have been described. These receptors detect various guidance cues including sphingosine-1-phosphate and chemokines that orchestrate NK cell trafficking. Here, we highlight recent advances regarding the receptors involved in NK cell migration, with a focus on bone marrow egress, entry into activated lymph nodes, extravasation into inflamed tissues, and motility within lymph nodes or tumors. Understanding NK cell migration could provide a rational basis for the design of novel therapies in various clinical conditions.

Link to HAL – hal-00611606

Link to DOI – 10.1016/j.it.2011.05.002