Publication: Evidence for early infection of nonneoplastic natural killer cells by Epstein-Barr virus.

Published in: Journal of Virology, 2002, pp.11139-11142. ⟨10.1128/JVI.76.21.11139-11142.2002⟩

Authors: Pascal Trempat, Julie Tabiasco, Pascale Andre, Nathalie Faumont, Fabienne Meggetto, Georges Delsol, Randy Gascoyne, Jean-Jacques Fournié, Eric Vivier, Pierre Brousset

Summary

We examined lymph nodes and tonsils from patients with infectious mononucleosis by combined detection of EBV-encoded RNA and a specific marker of natural killer (NK) cells, PEN5. A small number of Epstein-Barr virus (EBV) latently infected nonneoplastic NK cells were detected. Our data demonstrate that NK cells are natural targets of EBV and that infection of these cells is an early event observed during primary EBV infection.

Link to HAL – unilim-01759549

Link to DOI – 10.1128/JVI.76.21.11139-11142.2002