Delivering three punches to knockout intracellular bacteria.

Theme

Immunological memory within the innate immune system.

Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells.

Published in: Cell 2014 Jun; 157(6): 1251-1252

Authors: Narni-Mancinelli E, Vivier E

Summary

Cytotoxic lymphocytes kill bacteria-infected cells, but the mechanisms at work remain unclear. Walch et al. show that these lymphocytes deliver a toxic molecular trio in a two-step process, penetrating first the infected cells and then delivering bactericidal granzymes into the intracytoplasmic bacteria.

Link to Pubmed [PMID] – 24906142

Link to DOI – 10.1016/j.cell.2014.05.023