Publication: Coordination of activating and inhibitory signals in natural killer cells.

Published in: Molecular Immunology, 2005, 42 (4), pp.477-84. ⟨10.1016/j.molimm.2004.07.030⟩

Authors: Sabrina Chiesa, Elena Tomasello, Eric Vivier, Frédéric Vély

Summary

NK cells are equipped with multiple activating and inhibitory cell surface receptors whose engagement regulate NK cell effector function (i.e. cytotoxicity as well as chemokine and cytokine production). Several components (adaptors, effector molecules) that participate to NK cell signalling pathways have been described. Yet, the spatio-temporal organisation of these pathways is still poorly understood. In addition, the mechanisms that integrate several simultaneous input signals in NK cells remain to be elucidated.

Link to HAL – hal-00165713

Link to DOI – 10.1016/j.molimm.2004.07.030