Publication: B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors.

Published in: Cellular and Molecular Life Sciences, 2011, 68 (21), pp.3531-9. ⟨10.1007/s00018-011-0802-7⟩

Authors: Tomonori Kaifu, Bertrand Escalière, Louis Noël Gastinel, Eric Vivier, Myriam Baratin

Summary

Natural killer (NK) cells are lymphocytes of the innate immune system that sense target cells through a panel of activating and inhibitory receptors. Together with NKG2D, the natural cytotoxicity receptors (NCRs) are major activating receptors involved in tumor cell detection. Although numerous NKG2D ligands have been identified, characterization of the molecules interacting with the NCRs is still incomplete. The identification of B7-H6 as a counter structure of the NCR NKp30 shed light on the molecular basis of NK cell immunosurveillance. We review here the current knowledge on NKp30 and B7-H6, and we discuss their potential role in anti-tumor immunity.

Link to Pubmed [PMID] – 21877119

Link to HAL – hal-00667776

Link to DOI – 10.1007/s00018-011-0802-7