Régulation neuronale de l’immunité – CIML

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Theme

Innate lymphoid cells

Immunosurveillance of the central nervous system

Members

Research Director

Pierre-Vincent BARBON

Vincent FEUILLET

Research Officer

Tiphaine FOHRER

Guillaume HOEFFEL

Research Officer

Ferdinand JAGOT

Françoise UGOLINI

Research Engineer

About

Beyond the Frontiers of Immunology

The survival of living beings depends on their ability to develop defense mechanisms against the dangers present in their environment. These protective mechanisms involve functions of both the nervous system and the immune system, two systems generally considered autonomous entities with their own independent functions. Recent studies suggest that connections exist between these two major systems, but the functional consequences of these interactions and the underlying molecular mechanisms remain poorly understood. Our laboratory explores the regulatory role of the nervous system on the immune response and dissects the intimate mechanisms of this regulation.

Following tissue injury or infection, an inflammatory response develops and the nervous and immune systems are jointly activated. Activation of the nervous system is accompanied by the production of mediators both systemically (in the bloodstream) and locally (by the neurons themselves). Some of these molecules are capable of modulating the activity of immune cells.

Nous étudions le rôle ce ces interactions neuro-immunes dans différentes pathologies telles que le choc septique, des infections virales, le cancer ou des lésions de la peau. Plusieurs aspects de ces régulations neuro-immunes sont disséqués:

– the role of stress hormones, produced by the hypothalamic-pituitary-adrenal (or HPA) pathway and by the sympathetic nervous system.

– le rôle immunomodulateur des neurones sensoriels impliqués dans la sensibilité à la douleur

– Le rôle immunomodulateur des neurones sensoriels impliqués dans le toucher léger

Afin d’identifier la nature de ces signaux et disséquer l’impact physiologique et fonctionnel de ces régulations, une série de modèles de souris génétiquement modifiées sont étudiés en collaboration avec des chercheurs spécialistes en Neurosciences.

This work aims to open new avenues of interdisciplinary research in order to develop a more integrated vision of the host response against pathogens and, in turn, contribute to the discovery of new therapeutic targets.

News

RÉJANE RUA HIGHLIGHTED BY PROVENCE AND FRANCE 3.

Following the article published in La Provence on Wednesday, August 6, 2025, the work of Réjane Rua, Inserm team leader […]

a group of different colored plants on a white surface

CIML Celebrates International Immunology Day 2025: When Brain Meets Immunity

On the occasion of International Immunology Day 2025, under the theme “Brain and Immunity”, the Immunology Center of […]

Projects

Neuroimmune regulations in obesity and type 2 diabetes

Project: T2DRGMacPain Obesity is a major factor in metabolic disorders such as type 2 diabetes. Dysfunction of […]

Guillaume HOEFFEL

Neuroimmune interactions in cancer

Nerve fibers are increasingly emerging as key players in the tumor microenvironment, capable of modulating […]

Vincent FEUILLET

Neuroimmune regulations and viral infection

The host response to pathogens is orchestrated by the immune system and the nervous system, both present in […]

Regulation of inflammation by the neurokine TAFA4

We have demonstrated that the neurokine TAFA4, produced by sensory neurons in the skin, can promote tissue repair […]

Sensory neurons and immune regulation

Beyond the pain perception processes that are induced in the event of injury or infection of the […]

Régulations neuro-immunes de la régénération cutanée

Les macrophages résidents des tissus jouent un rôle fondamental dans l’homéostasie tissulaire et sa régénération après lésion. Dans un modèle […]

Guillaume HOEFFEL

Publications

Crosson T, Bretaud N, Ugolini S, Role of specialized sensory neuron subtypes in modulating peripheral immune responses. Immunity 2025 May; 58(5): 1161-1174.

Culley G, Henriques A, Hardy D, Wojcinski A, Chabert A, El Waly B, Poindron P, Callizot N, Amyloid-beta peptide toxicity in the aged brain is a one-way journey into Alzheimer’s disease., Front Aging Neurosci 2025 ; 17(): 1569181.

Chahla C, Rima M, Mouawad C, Roufayel R, Kovacic H, El Obeid D, Sabatier JM, Luis J, Fajloun Z, El-W..., Effect of Apis mellifera syriaca Bee Venom on Glioblastoma Cancer: In Vitro and In Vivo Studies., Molecules 2024 Aug; 29(16): .

Reynders A, Anissa Jhumka Z, Gaillard S, Mantilleri A, Malapert P, Magalon K, Etzerodt A, Salio C, U..., Gut microbiota promotes pain chronicity in Myosin1A deficient male mice. Brain Behav Immune 2024 Jul; 119(): 750-766.

Mardelle U, Bretaud N, Daher C, Sheet V, From pain to tumor immunity: influence of peripheral sensory neurons in cancer. Front Immunol 2024; 15(): 1335387.

Seipp RP, Hoeffel G, Moise AR, Lok S, Ripoche AC, Marañón C, Hosmalin A, Jefferies WA, A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation., Front Immunol 2024 ; 15(): 1525136.

Jagot F, Gaston-Breton R, Choi AJ, Pascal M, Bourhy L, Dorado-Doncel R, Conzelmann KK, Lledo PM, Lep..., The parabrachial nucleus elicits a vigorous corticosterone feedback response to the pro-inflammatory cytokine IL-1β. Neuron 2023 Aug; 111(15): 2367-2382.e6.

Feuillet V, Ugolini S, Reynders A, Differential regulation of cutaneous immunity by sensory neuron subsets. Trends Neurosci 2023 Aug; 46(8): 640-653.

Escarrat V, Perez-Sanchez J, El-Waly B, Collazos-Castro JE, Debarbieux F, Composite Fibrin and Carbon Microfibre Implant to Modulate Postraumatic Inflammation after Spinal Cord Injury., Cells 2023 Mar; 12(6): .

Buttigieg E, Scheller A, El Waly B, Kirchhoff F, Debarbieux F, Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis., Neurotherapeutics 2023 Jan; 20(1): 22-38.

El Waly B, Bertet C, Paris M, Falque M, Milpied P, Magalon K, Cayre M, Durbec P, Neuroblasts contribute to oligodendrocytes generation upon demyelination in the adult mouse brain. iScience 2022 Oct; 25(10): 105102.

Henriques A, Rouvière L, Giorla E, Farrugia C, El Waly B, Poindron P, Callizot N, Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo Evidence., Int J Mol Sci 2022 Aug; 23(17): .

Roger A, Reynders A, Hoeffel G, Ugolini S, Neuroimmune crosstalk in the skin: a delicate balance governing inflammatory processes. Curr Opin Immunol 2022 Aug; 77(): 102212.

Bellon A, Feuillet V, Cortez-Resendiz A, Mouaffak F, Kong L, Hong LE, De Godoy L, Jay TM, Hosmalin A..., Dopamine-induced pruning in monocyte-derived-neuronal-like cells (MDNCs) from patients with schizophrenia. Mol Psychiatry 2022 Jun; 27(6): 2787-2802.

Yonekura S, Terrisse S, Alves Costa Silva C, Lafarge A, Iebba V, Ferrere G, Goubet AG, Fahrner JE, L..., Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis. Cancer Discov 2022 Apr; 12(4): 1128-1151.

Pascal M, Kazakov A, Chevalier G, Dubrule L, Deyrat J, Dupin A, Saha S, Jagot F, Sailor K, Dulauroy ..., The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding., Mucosal Immunol 2022 Apr; 15(4): 629-641.

Yoo S, Santos C, Reynders A, Marics I, Malapert P, Gaillard S, Charron A, Ugolini S, Rossignol R, El..., TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current. Cell Rep 2021 Oct; 37(4): 109884.

Ferdinand Jagot, The brain circuits controlling the immunosuppressive response to the pro-inflammatory cytokine IL-1ß The neural circuits that control the immunosuppressive response induced by the pro-inflammatory cytokine IL-1ß, Immunology. University of Paris City, 2021. English. <a target="_blank" href="https://www.theses.fr/2021UNIP7288">⟨NNT : 2021UNIP7288⟩</a>.

Pellefigues C, Naidoo K, Mehta P, Schmidt AJ, Jagot F, Roussel E, Cait A, Yumnam B, Chappell S, Meij..., Basophils promote barrier dysfunction and resolution in the atopic skin. J Allergy Clin Immunol 2021 Sep; 148(3): 799-812.e10.

Raynier Devillier, Boris Calmels, Sophie Guia, Mohammed Taha, Cyril Fauriat, Bechara Mfarrej, Geoffr..., Phase I Trial of Prophylactic Donor-Derived IL-2-Activated NK Cell Infusion after Allogeneic Hematopoietic Stem Cell Transplantation from a Matched Sibling Donor, <i>Cancers</i>, 2021, 13 (11), pp.2673. <a target="_blank" href="https://dx.doi.org/10.3390/cancers13112673">⟨10.3390/cancers13112673⟩</a>.

Hoeffel G, Debroas G, Roger A, Rossignol R, Gouilly J, Laprie C, Chasson L, Barbon PV, Balsamo A, Re..., Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions. Nature 2021 Jun; 594(7861): 94-99.

Filtjens J, Roger A, Quatrini L, Wieduwild E, Gouilly J, Hoeffel G, Rossignol R, Daher C, Debroas G,..., Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection. Nat Commun 2021 May; 12(1): 2936.

Quatrini L, Ugolini S, New insights into the cell- and tissue-specificity of glucocorticoid actions. Cell Mol Immunol 2021 Feb; 18(2): 269-278.

El Waly B, Escarrat V, Perez-Sanchez J, Kaur J, Pelletier F, Collazos-Castro JE, Debarbieux F, Intravital Assessment of Cells Responses to Conducting Polymer-Coated Carbon Microfibres for Bridging Spinal Cord Injury., Cells 2021 Jan; 10(1): .

Sheet V, Canard B, Trautmann A, Combining Antivirals and Immunomodulators to Fight COVID-19. Trends Immunol 2021 Jan; 42(1): 31-44.

Quatrini L, Vacca P, Tumino N, Besi F, Di Pace AL, Scordamaglia F, Martini S, Munari E, Mingari MC, ..., Glucocorticoids and the cytokines IL-12, IL-15, and IL-18 present in the tumor microenvironment induce PD-1 expression on human natural killer cells. J Allergy Clin Immunol 2021 Jan; 147(1): 349-360.

Julien Carvelli, Olivier Demaria, Frédéric Vély, Luciana Batista, Nassima Chouaki Benmansour, Joa..., Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis, 2024.

El Waly B, Mignon-Ravix C, Cacciagli P, Buhler E, Ben Zeev B, Villard L, Molecular characterization of a 1p36 chromosomal duplication and in utero interference define ENO1 as a candidate gene for polymicrogyria., Eur J Hum Genet 2020 Dec; 28(12): 1703-1713.

Wieduwild É, Daher C, Ugolini S, [Stress-related adrenergic signals weaken antiviral immune defenses]. Med Sci (Paris) 2020 Nov; 36(11): 993-996.

Matthias Hofer, Siddarth Shivkumar, Bilal El Waly, Sophie Brasselet, Coherent Anti-Stokes Raman Scattering Through Thick Biological Tissues by Single-Wavefront Shaping, <i>Physical Review Applied</i>, 2020, 14 (2), <a target="_blank" href="https://dx.doi.org/10.1103/PhysRevApplied.14.024019">⟨10.1103/PhysRevApplied.14.024019⟩</a>.

Macchi M, Magalon K, Zimmer C, Peeva E, El Waly B, Brousse B, Jaekel S, Grobe K, Kiefer F, Williams ..., Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production., Elife 2020 Jun; 9(): .

Adeline Crinier, Emilie Narni-Mancinelli, Sophie Ugolini, Eric Vivier, SnapShot: Natural Killer Cells, <i>Cell</i>, 2020, 180 (6), pp.1280-1280.e1. <a target="_blank" href="https://dx.doi.org/10.1016/j.cell.2020.02.029">⟨10.1016/j.cell.2020.02.029⟩</a>.

Garvin Dodard, Angela Tata, Timothy Erick, Diego Jaime, SM Shahjahan Miah, Linda Quatrini, Bertran..., Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells, <i>Cell Reports</i>, 2020, 32 (1), pp.107855. <a target="_blank" href="https://dx.doi.org/10.1016/j.celrep.2020.107855">⟨10.1016/j.celrep.2020.107855⟩</a>.

Quatrini L, Ugolini S, Protocol for Determining the Effect of Neuroendocrine Hormones on Murine ILC Function. Methods Mol Biol 2020; 2121(): 83-92.

El Waly B, Buttigieg E, Karakus C, Brustlein S, Debarbieux F, Longitudinal Intravital Microscopy Reveals Axon Degeneration Concomitant With Inflammatory Cell Infiltration in an LPC Model of Demyelination., Front Cell Neurosci 2020 ; 14(): 165.

Daher C, Vimeux L, Stoeva R, Peranzoni E, Bismuth G, Wieduwild E, Lucas B, Donnadieu E, Bercovici N,..., Blockade of β-Adrenergic Receptors Improves CD8+ T-cell Priming and Cancer Vaccine Efficacy. Cancer Immunol Res 2019 Nov; 7(11): 1849-1863.

Davies AJ, Kim HW, Gonzalez-Cano R, Choi J, Back SK, Roh SE, Johnson E, Gabriac M, Kim MS, Lee J, Le..., Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell 2019 Feb; 176(4): 716-728.e18.

Gentek R, Ghigo C, Hoeffel G, Jorquera A, Msallam R, Wienert S, Klauschen F, Ginhoux F, Bajénoff M, Correction: Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult. J Exp Med 2018 Dec; 215(12): 3213.

Gentek R, Ghigo C, Hoeffel G, Jorquera A, Msallam R, Wienert S, Klauschen F, Ginhoux F, Bajénoff M, Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renewed in the adult. J Exp Med 2018 Dec; 215(12): 2994-3005.

Naidoo K, Jagot F, van den Elsen L, Pellefigues C, Jones A, Luo H, Johnston K, Painter G, Roediger B..., Eosinophils Determine Dermal Thickening and Water Loss in an MC903 Model of Atopic Dermatitis. J Invest Dermatol 2018 Dec; 138(12): 2606-2616.

Crinier A, Milpied P, Escalière B, Piperoglou C, Galluso J, Balsamo A, Spinelli L, Cervera-Marzal I..., High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice. Immunity 2018 Nov; 49(5): 971-986.e5.

Francisca Almeida, Sara Tognarelli, Antoine Marçais, Andrew Kueh, Miriam Friede, Yang Liao, Simon W..., A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets, <i>OncoImmunology</i>, 2018, 7 (10), pp.e1475875. <a target="_blank" href="https://dx.doi.org/10.1080/2162402X.2018.1475875">⟨10.1080/2162402X.2018.1475875⟩</a>.

Hoeffel G, Ginhoux F, Fetal monocytes and the origins of tissue-resident macrophages., Cell Immunol 2018 Aug; 330(): 5-15.

Pascale Durbec, Myriam Cayre, Bilal El Waly, Commentary: “Promoting Myelin Repair through In vivo Neuroblast Reprogramming, <i>Journal of Neurology & Neuromedicine</i>, 2018, 3 (4), pp.15-17. <a target="_blank" href="https://dx.doi.org/10.29245/2572.942X/2018/4.1196">⟨10.29245/2572.942X/2018/4.1196⟩</a>.

Gentek R, Ghigo C, Hoeffel G, Bulle MJ, Msallam R, Gautier G, Launay P, Chen J, Ginhoux F, Bajénoff..., Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells. Immunity 2018 Jun; 48(6): 1160-1171.e5.

El Waly B, Cayre M, Durbec P, Promoting Myelin Repair through In Vivo Neuroblast Reprogramming., Stem Cell Reports 2018 May; 10(5): 1492-1504.

Debroas G, Hoeffel G, Reynders A, Ugolini S, [Neuroimmune interactions in the skin: a link between pain and immunity]. Med Sci (Paris) 2018 May; 34(5): 432-438.

Ochiai S, Jagot F, Kyle RL, Hyde E, White RF, Prout M, Schmidt AJ, Yamane H, Lamiable O, Le Gros G, ..., Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells. Proc Natl Acad Sci USA 2018 Jan; 115(5): 1033-1038.

Thion MS, Low D, Silvin A, Chen J, Grisel P, Schulte-Schrepping J, Blecher R, Ulas T, Squarzoni P, H..., Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner., Cell 2018 Jan; 172(3): 500-516.e16.

Linda Quatrini, Eric Vivier, Sophie Ugolini, Neuroendocrine regulation of innate lymphoid cells, <i>Immunological reviews</i>, 2018, 286 (1), pp.120--136. <a target="_blank" href="https://dx.doi.org/10.1111/imr.12707">⟨10.1111/imr.12707⟩</a>.

Wared Nour-Eldine, Jérémie Joffre, Kazem Zibara, Bruno Esposito, Andreas Giraud, Lynda Zeboudj, Jo..., Genetic Depletion or Hyperresponsiveness of Natural Killer Cells Do Not Affect Atherosclerosis Development, <i>Circulation Research</i>, 2017, Epub ahead of print. <a target="_blank" href="https://dx.doi.org/10.1161/CIRCRESAHA.117.311743">⟨10.1161/CIRCRESAHA.117.311743⟩</a>.

Quatrini L, Ugolini S, Disarming the Killers: Brain Strikes on NK Cells. Immunity 2017 Mar; 46(3): 340-342.

Viant C, Guia S, Hennessy RJ, Rautela J, Pham K, Bernat C, Goh W, Jiao Y, Delconte R, Roger M, Simon..., Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. J Exp Med 2017 Feb; 214(2): 491-510.

Emilie Narni-Mancinelli, Laurent Gauthier, Myriam Baratin, Sophie Guia, Aurore Fenis, Ala-Eddine Deg..., Complement factor P is a ligand for the natural killer cell-activating receptor NKp46, <i>Science Immunology</i>, 2017, 2 (10), pp.aam9628. <a target="_blank" href="https://dx.doi.org/10.1126/sciimmunol.aam9628">⟨10.1126/sciimmunol.aam9628⟩</a>.

Linda Quatrini, Elisabeth Wieduwild, Sophie Guia, Claire Bernat, Nicolas Glaichenhaus, Eric Vivier, ..., Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells, <i>Journal of Experimental Medicine</i>, 2017, 214 (12), pp.3531-3541. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20171048">⟨10.1084/jem.20171048⟩</a>.

Jagot F, Davoust N, [MiRNAs: new actors in the physiopathology of multiple sclerosis]. Med Sci (Paris) 2017; 33(6-7): 620-628.

Gentek R, Hoeffel G, The Innate Immune Response in Myocardial Infarction, Repair, and Regeneration., Adv Exp Med Biol 2017 ; 1003(): 251-272.

Blanc P, Moro-Sibilot L, Barthly L, Jagot F, This S, de Bernard S, Buffat L, Dussurgey S, Colisson R..., Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge. Nat Commun 2016 Dec; 7(): 13600.

Magalon K, Le Grand M, El Waly B, Moulis M, Pruss R, Bordet T, Cayre M, Belenguer P, Carré M, Durbe..., Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules., Neuropharmacology 2016 Dec; 111(): 293-303.

Lucille C. Rankin, Mathilde JH Girard-Madoux, Cyril Seillet, Lisa A. Mielke, Yann Kerdiles, Auror..., Complementarity and redundancy of IL-22-producing innate lymphoid cells, <i>Nature Immunology</i>, 2016, 17 (2), pp.179-186. <a target="_blank" href="https://dx.doi.org/10.1038/ni.3332">⟨10.1038/ni.3332⟩</a>.

Chabannon C, Mfarrej B, Guia S, Ugolini S, Devillier R, Blaise D, Vivier E, Calmels B, Manufacturing Natural Killer Cells as Medicinal Products. Front Immunol 2016; 7():504.

Jagot F, Davoust N, Is It worth Considering Circulating microRNAs in Multiple Sclerosis? Front Immunol 2016; 7(): 129.

El Waly B, Buhler E, Haddad MR, Villard L, Nhej1 Deficiency Causes Abnormal Development of the Cerebral Cortex., Mol Neurobiol 2015 Aug; 52(1): 771-82.

Almeida FF, Tenno M, Brzostek J, Li JL, Allies G, Hoeffel G, See P, Ng LG, Fehling HJ, Gascoigne NR,..., Identification of a novel lymphoid population in the murine epidermis., Sci Rep 2015 Jul; 5(): 12554.

Hoeffel G, Chen J, Lavin Y, Low D, Almeida FF, See P, Beaudin AE, Lum J, Low I, Forsberg EC, Poiding..., C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages., Immunity 2015 Apr; 42(4): 665-78.

Hoeffel G, Ginhoux F, Ontogeny of Tissue-Resident Macrophages., Front Immunol 2015 ; 6(): 486.

Viant C, Fenis A, Chicanne G, Payrastre B, Ugolini S, Vivier E, SHP-1-mediated inhibitory signals promote responsiveness and anti-tumor functions of natural killer cells. Nat Commun 2014 Oct;5():5108.

Squarzoni P, Oller G, Hoeffel G, Pont-Lezica L, Rostaing P, Low D, Bessis A, Ginhoux F, Garel S, Microglia modulate wiring of the embryonic forebrain., Cell Rep 2014 Sep; 8(5): 1271-9.

Sun JC, Ugolini S, Vivier E, Immunological memory within the innate immune system. EMBO J 2014 Jun; 33(12): 1295-303.

Kruse PH, Matta J, Ugolini S, Vivier E, Natural cytotoxicity receptors and their ligands. Immunol Cell Biol 2014 Mar; 92(3): 221-9.

Kohrt HE, Thielens A, Marabelle A, Sagiv-Barfi I, Sola C, Chanuc F, Fuseri N, Bonnafous C, Czerwinsk..., Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies. Blood 2014 Jan; 123(5): 678-86.

El Waly B, Macchi M, Cayre M, Durbec P, Oligodendrogenesis in the normal and pathological central nervous system., Front Neurosci 2014 ; 8(): 145.

Eric Vivier, Sophie Ugolini, Jacques A. Nunès, ADAPted secretion of cytokines in NK cells. <i>Nature Immunology</i>, 2013, 14 (11), pp.1108-10. <a target="_blank" href="https://dx.doi.org/10.1038/ni.2737">⟨10.1038/ni.2737⟩</a>.

Matta J, Baratin M, Chiche L, Forel JM, Cognet C, Thomas G, Farnarier C, Piperoglou C, Papazian L, C..., Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. Blood 2013 Jul; 122(3): 394-404.

Kerdiles Y, Ugolini S, Vivier E, T cell regulation of natural killer cells. J Exp Med 2013 Jun;210(6):1065-8.

Schlitzer A, McGovern N, Teo P, Zelante T, Atarashi K, Low D, Ho AW, See P, Shin A, Wasan PS, Hoeffe..., IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses., Immunity 2013 May; 38(5): 970-83.

Narni-Mancinelli E, Ugolini S, Vivier E, [Natural killer cells: adaptation and memory in innate immunity]. Med Sci (Paris) 2013 Apr; 29(4): 389-95.

Narni-Mancinelli E, Ugolini S, Vivier E, Tuning the threshold of natural killer cell responses. Curr Opin Immunol 2013 Feb; 25(1): 53-8.

Ginhoux F, Lim S, Hoeffel G, Low D, Huber T, Origin and differentiation of microglia., Front Cell Neurosci 2013 ; 7(): 45.

Greter M, Lelios I, Pelczar P, Hoeffel G, Price J, Leboeuf M, Kündig TM, Frei K, Ginhoux F, Merad M..., Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia., Immunity 2012 Dec; 37(6): 1050-1060.

Hoeffel G, Wang Y, Greter M, See P, Teo P, Malleret B, Leboeuf M, Low D, Oller G, Almeida F, Choy SH..., Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages., J Exp Med 2012 Jun; 209(6): 1167-81.

Baptiste N Jaeger, Jean Donadieu, Céline Cognet, Claire Bernat, Diana Ordoñez-Rueda, Vincent Barlo..., Neutrophil depletion odd natural killer cell maturation, function, and homeostasis. <i>Journal of Experimental Medicine</i>, 2012, 209 (3), pp.565-80. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20111908">⟨10.1084/jem.20111908⟩</a>.

Emilie Narni-Mancinelli, Baptiste N. Jaeger, Claire Bernat, Aurore Fenis, Sam Kung, Aude de Gassart,..., Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. <i>Science</i>, 2012, 335 (6066), pp.344-8. <a target="_blank" href="https://dx.doi.org/10.1126/science.1215621">⟨10.1126/science.1215621⟩</a>.

Eric Vivier, Sophie Ugolini, Didier Blaise, Christian Chabannon, Laurent Brossay, Targeting natural killer cells and natural killer T cells in cancer. <i>Nature Reviews Immunology</i>, 2012, 12 (4), pp.239-52. <a target="_blank" href="https://dx.doi.org/10.1038/nri3174">⟨10.1038/nri3174⟩</a>.

Emilie Narni-Mancinelli, Julie Chaix, Aurore Fenis, Yann M Kerdiles, Nadia Yessaad, Ana Reynders, Cl..., Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor. <i>Proceedings of the National Academy of Sciences of the United States of America</i>, 2011, 108 (45), pp.18324-9. <a target="_blank" href="https://dx.doi.org/10.1073/pnas.1112064108">⟨10.1073/pnas.1112064108⟩</a>.

Karine Crozat, Céline Eidenschenk, Baptiste N Jaeger, Philippe Krebs, Sophie Guia, Bruce Beutler, E..., Impact of β2 integrin deficiency on mouse natural killer cell development and function. <i>Blood</i>, 2011, 117 (10), pp.2874-82. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2010-10-315457">⟨10.1182/blood-2010-10-315457⟩</a>.

Eric Vivier, David H Raulet, Alessandro Moretta, Michael A Caligiuri, Laurence Zitvogel, Lewis L Lan..., Innate or adaptive immunity? The example of natural killer cells. <i>Science</i>, 2011, 331 (6013), pp.44-9. <a target="_blank" href="https://dx.doi.org/10.1126/science.1198687">⟨10.1126/science.1198687⟩</a>.

Sophie Guia, Baptiste N Jaeger, Stefan Piatek, Sébastien Mailfert, Tomasz Trombik, Aurore Fenis, Ni..., Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. <i>Science Signaling</i>, 2011, 4 (167), pp.ra21. <a target="_blank" href="https://dx.doi.org/10.1126/scisignal.2001608">⟨10.1126/scisignal.2001608⟩</a>.

Vivier E, Ugolini S, Natural killer cells: from basic research to treatments. Front Immunol 2011;2():18.

Cacciagli P, Haddad MR, Mignon-Ravix C, El-Waly B, Moncla A, Missirian C, Chabrol B, Villard L, Disruption of the ATP8A2 gene in a patient with a t(10;13) de novo balanced translocation and a severe neurological phenotype., Eur J Hum Genet 2010 Dec; 18(12): 1360-3.

Matheoud D, Perié L, Hoeffel G, Vimeux L, Parent I, Marañón C, Bourdoncle P, Renia L, Prevost-Blo..., Cross-presentation by dendritic cells from live cells induces protective immune responses in vivo., Blood 2010 Jun; 115(22): 4412-20.

Bauby H, Lopez-Vergès S, Hoeffel G, Delcroix-Genête D, Janvier K, Mammano F, Hosmalin A, Berlioz-T..., TIP47 is required for the production of infectious HIV-1 particles from primary macrophages., Traffic 2010 Apr; 11(4): 455-67.

Mignon-Ravix C, Cacciagli P, El-Waly B, Moncla A, Milh M, Girard N, Chabrol B, Philip N, Villard L, Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia., J Med Genet 2010 Feb; 47(2): 132-6.

Eric Vivier, Sophie Ugolini, Regulatory natural killer cells: new players in the IL-10 anti-inflammatory response. <i>Cell Host and Microbe</i>, 2009, 6 (6), pp.493-5. <a target="_blank" href="https://dx.doi.org/10.1016/j.chom.2009.12.001">⟨10.1016/j.chom.2009.12.001⟩</a>.

Caroline Sola, Pascale André, Céline Lemmers, Nicolas Fuseri, Cécile Bonnafous, Mathieu Bléry, N..., Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. <i>Proceedings of the National Academy of Sciences of the United States of America</i>, 2009, 106 (31), pp.12879-84. <a target="_blank" href="https://dx.doi.org/10.1073/pnas.0901653106">⟨10.1073/pnas.0901653106⟩</a>.

Sophie Ugolini, Eric Vivier, Immunology: Natural killer cells remember. <i>Nature</i>, 2009, 457 (7229), pp.544-5. <a target="_blank" href="https://dx.doi.org/10.1038/457544a">⟨10.1038/457544a⟩</a>.

Eric Vivier, Elena Tomasello, Myriam Baratin, Thierry Walzer, Sophie Ugolini, Functions of natural killer cells. <i>Nature Immunology</i>, 2008, 9 (5), pp.503-10. <a target="_blank" href="https://dx.doi.org/10.1038/ni1582">⟨10.1038/ni1582⟩</a>.

Paruch S, Heinis M, Lemay J, Hoeffel G, Marañón C, Hosmalin A, Périanin A, CCR5 signaling through phospholipase D involves p44/42 MAP-kinases and promotes HIV-1 LTR-directed gene expression., FASEB J 2007 Dec; 21(14): 4038-46.

Shen-Ying Zhang, Emmanuelle Jouanguy, Sophie Ugolini, Asma Smahi, Gaëlle Elain, Pedro Romero, David..., TLR3 deficiency in patients with herpes simplex encephalitis. <i>Science</i>, 2007, 317 (5844), pp.1522-7. <a target="_blank" href="https://dx.doi.org/10.1126/science.1139522">⟨10.1126/science.1139522⟩</a>.

, Antigen crosspresentation by human plasmacytoid dendritic cells., Immunity 2007 Sep; 27(3): 481-92.

Karine Crozat, Kasper Hoebe, Sophie Ugolini, Nancy A Hong, Edith Janssen, Sophie Rutschmann, Suzanne..., Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. <i>Journal of Experimental Medicine</i>, 2007, 204 (4), pp.853-63. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20062447">⟨10.1084/jem.20062447⟩</a>.

Myriam Baratin, Sophie Roetynck, Bruno Pouvelle, Céline Lemmers, Nicola K Viebig, Sofia Johansson, ..., Dissection of the role of PfEMP1 and ICAM-1 in the sensing of plasmodium falciparum-infected erythrocytes by natural killer cells. <i>PLoS ONE</i>, 2007, 2 (2), pp.e228. <a target="_blank" href="https://dx.doi.org/10.1371/journal.pone.0000228">⟨10.1371/journal.pone.0000228⟩</a>.

Sophie Roetynck, Myriam Baratin, Sofia Johansson, Céline Lemmers, Eric Vivier, Sophie Ugolini, Natural killer cells and malaria. <i>Immunological Reviews</i>, 2006, 214, pp.251-63. <a target="_blank" href="https://dx.doi.org/10.1111/j.1600-065X.2006.00446.x">⟨10.1111/j.1600-065X.2006.00446.x⟩</a>.

Nicolas Anfossi, Pascale André, Sophie Guia, Christine S Falk, Sophie Roetynck, C Andrew Stewart, V..., Human NK cell education by inhibitory receptors for MHC class I, <i>Immunity</i>, 2006, 25 (2), pp.331-42. <a target="_blank" href="https://dx.doi.org/10.1016/j.immuni.2006.06.013">⟨10.1016/j.immuni.2006.06.013⟩</a>.

Van Gulck ER, Ponsaerts P, Heyndrickx L, Vereecken K, Moerman F, De Roo A, Colebunders R, Van den Bo..., Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins., Blood 2006 Mar; 107(5): 1818-27.

Roetynck S, Baratin M, Vivier E, Ugolini S, [NK cells and innate immunity to malaria]. Med Sci (Paris) 2006; 22(8-9): 739-44.

Baratin M, Roetynck S, Lépolard C, Falk C, Sawadogo S, Uematsu S, Akira S, Ryffel B, Tiraby JG, Ale..., Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum. Proc Natl Acad Sci USA 2005 Oct; 102(41): 14747-52.

Stewart CA, Laugier-Anfossi F, Vély F, Saulquin X, Riedmuller J, Tisserant A, Gauthier L, Romagné ..., Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci USA 2005 Sep; 102(37): 13224-9.

Jeannin P, Bottazzi B, Sironi M, Doni A, Rusnati M, Presta M, Maina V, Magistrelli G, Haeuw JF, Hoef..., Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors., Immunity 2005 May; 22(5): 551-60.

Anfossi N, Doisne JM, Peyrat MA, Ugolini S, Bonnaud O, Bossy D, Pitard V, Merville P, Moreau JF, Del..., Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells. J Immunol 2004 Dec; 173(12): 7223-9.

Anfossi N, Robbins SH, Ugolini S, Georgel P, Hoebe K, Bouneaud C, Ronet C, Kaser A, DiCioccio CB, To..., Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. J Immunol 2004 Sep; 173(6): 3773-82.

Marañón C, Desoutter JF, Hoeffel G, Cohen W, Hanau D, Hosmalin A, Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4+ T lymphocytes., Proc Natl Acad Sci U S A 2004 Apr; 101(16): 6092-7.

Maisnier-Patin K, Malissard M, Jeannin P, Haeuw JF, Corbière JC, Hoeffel G, Gauchat JF, Nguyen T, S..., The outer membrane protein X from Escherichia coli exhibits immune properties., Vaccine 2003 Sep; 21(25-26): 3765-74.

Filippi C, Hugues S, Cazareth J, Julia V, Glaichenhaus N, Ugolini S, CD4+ T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells. J Exp Med 2003 Jul; 198(2): 201-9.

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