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About

Career:

Carole Berruyer is a Senior Lecturer at Aix-Marseille University (AMU), where she was recruited in 2008. Her career began at the Marseille Luminy Immunology Center (CIML), with a thesis defended in 2004 under the supervision of Professor Philippe Naquet, devoted to the role of the epithelial molecule Vanin in intestinal inflammation and the antioxidant response. She then completed two post-doctoral positions: the first at the CRCM (Patrice Dubreuil) on Nectin-4 and TACE in breast cancer, then the second at the Lawrence Berkeley National Laboratory (Mina Bissell, California) on Ephrins in breast development and tumorigenesis. In 2008, she joined the CIML in Michael Sieweke's team, where she founded a mini-group on macrophage proliferation and self-renewal. Since 2019, she has continued her research in the laboratory of Professor Éric Vivier, exploring the impact of innate lymphoid cells in inflammatory and cancerous pathologies.

Expertise:

A specialist in innate immunity, Carole Berruyer has acquired expertise at the interface of immunology, cell biology, and cancerology. Her research covers topics ranging from epithelial molecules to innate myeloid and lymphoid cells. She is also heavily involved in teaching. As head of the Master 1 in Immunology, she coordinates several courses, from undergraduate to graduate level. Her courses include an introductory immunology course in L2 (nearly 300 students), the "Basics of Cellular and Molecular Immunology" course (also open to the Health track), and a practical cytometry and imaging workshop. She has supervised two doctoral students, three master's students, around ten engineers, and numerous undergraduate students. Since 2016, she has also contributed to the continuing education of private companies.

Internal cross-functional missions at CIML:

Within the CIML, Carole Berruyer has taken on increasing responsibilities in organizing training. Since June 2024, she has served as the center's Education and Training Advisor, a role that places her at the interface between research and teaching. This cross-functional role complements her teaching and supervision activities, strengthening the coherence and visibility of the training initiatives carried out by the CIML.

External institutional missions:

On the institutional level, she has been an elected member of the UFR council since 2022 and sits on the university's teaching committee. She actively participates in the educational committee for the selection of students for the Master of Immunology (nearly 500 applications per year) and is a permanent member of the M1 and M2 juries. She also takes part in the recruitment of immunology teachers at AMU. Through these commitments, she contributes to the university's institutional influence and to the development of the immunology training offer.

Publications

2024
Emilie Narni-Mancinelli, Carole Berruyer, Eric Vivier, On blood and tissue-resident natural killer cells, <i>Immunity</i>, 2024, 57 (1), pp.6-8. <a target="_blank" href="https://dx.doi.org/10.1016/j.immuni.2023.12.013">⟨10.1016/j.immuni.2023.12.013⟩</a>.
2021
Crinier A, Kerdiles Y, Vienne M, Cózar B, Vivier E, Berruyer C, Multidimensional molecular controls defining NK/ILC1 identity in cancers. Semin Immunol 2021 Feb; 52(): 101424.
2017
Francesco Imperatore, Julien Maurizio, Stephanie Vargas Aguilar, Clara J. Busch, Jeremy Favret, Elis..., SIRT1 regulates macrophage self-renewal, <i>EMBO Journal</i>, 2017, 36 (16), pp.2353-2372. <a target="_blank" href="https://dx.doi.org/10.15252/embj.201695737">⟨10.15252/embj.201695737⟩</a>.
2016
Prashanth Kandalla, Sandrine Sarrazin, Kaaweh Molawi, Carole Berruyer, David Redelberger, Anne Favel..., M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation. <i>Journal of Experimental Medicine</i>, 2016, 213 (11), pp.2269-2279. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20151975">⟨10.1084/jem.20151975⟩</a>.
2016
Erinn L. Soucie, Ziming Weng, Laufey Geirsdottir, Kaaweh Molawi, Julien Maurizio, Romain Fenouil, No..., Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells, <i>Science</i>, 2016, 351 (6274), pp.680-U123. <a target="_blank" href="https://dx.doi.org/10.1126/science.aad5510">⟨10.1126/science.aad5510⟩</a>.
2014
Joséphine Zangari, Mariagrazia Partisani, François Bertucci, Julie Milanini, Ghislain Bidaut, Caro..., EFA6B Antagonizes Breast Cancer, <i>Cancer Research</i>, 2014, 74 (19), pp.5493-5506. <a target="_blank" href="https://dx.doi.org/10.1158/0008-5472.can-14-0298">⟨10.1158/0008-5472.can-14-0298⟩</a>.
2012
Mezil L, Berruyer-Pouyet C, Cabaud O, Josselin E, Combes S, Brunel JM, Viens P, Collette Y, Birnbaum..., Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS One 2012;7(9):e43409.
2007
Fabre-Lafay S, Monville F, Garrido-Urbani S, Berruyer-Pouyet C, Ginestier C, Reymond N, Finetti P, S..., Nectin-4 is a new histological and serological tumor associated marker for breast cancer. BMC Cancer 2007 May;7():73.
2007
Soraya Meghari, Carole Berruyer, Hubert Lepidi, Franck Galland, Philippe Naquet, Jean-Louis Mege, Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection. <i>European Journal of Immunology</i>, 2007, 37 (1), pp.24-32. <a target="_blank" href="https://dx.doi.org/10.1002/eji.200636054">⟨10.1002/eji.200636054⟩</a>.
2006
Carole Berruyer, Laurent Pouyet, Virginie Millet, Florent M Martin, Aude Legoffic, Alexandra Canonic..., Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. <i>Journal of Experimental Medicine</i>, 2006, 203 (13), pp.2817-27. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20061640">⟨10.1084/jem.20061640⟩</a>.
2004
Berruyer C, Martin FM, Castellano R, Macone A, Malergue F, Garrido-Urbani S, Millet V, Imbert J, Dup..., Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress. Mol Cell Biol 2004 Aug; 24(16): 7214-24.