À propos
ORCID: 0000-0002-6436-7966
h-Index: 63; 16,241 citations; >135 publications (54 as leading author, including 20 cited >100 times each).
Source: Web of Science.
Education
11/2007, Accreditation to supervise research (HDR; Immunology), Aix Marseille University.
06/1999, PhD, Immunology, University Paris 6.
07/1994, Master, Immunology, University Paris 6.
07/1994, Master, Biology & Biochemistry, Ecole Normale Supérieure, Paris.
Expertise: Dendritic cell (DC) biology, antiviral/tumor immunity, functional genomics, single-cell omics.
Objective: Understanding how DC types and activation states control disease, in viral infections, cancers, inflammatory disorders.
Major Achievements
PhD (with Drs Jean-Gérard Guillet & Elisabeth Gomard, Cochin Institute, Paris): Phenotypic, functional, and antigenic repertoire characterization of anti-HIV-1 CD8+ T cells (1996: AIDS Res Hum Retroviruses; 1998: J Infect Dis; 1999: J Virol, Eur J Immunol, J Clin Invest).
Post-doc (with Pr. Christine A. Biron, Brown University, Providence, RI, USA): Discovery and first in vivo functional study of murine plasmacytoid DC (pDC) (2001: Nat Immunol; 2002 & 2003: J Exp Med).
CIML (team leader since 2004): Deciphering the identity, functions, and molecular regulation of pDC and cDC1.
*Mechanisms controlling interferon production by murine pDC and their functional diversification (2002 & 2003: J Exp Med; 2018: EMBO J; 2020 & 2023: Nat Immunol), with a deleterious role in severe respiratory viral infections (2025: Nat Immunol).
*Identification of equivalencies between human & mouse DC types, including between human CD141(BDCA3)+ and murine CD8α/CD103+ DC (2008: Genome Biol; 2010: J Exp Med), via comparative genomics applied to immune cells; pioneering cross-species studies that initiated the development of a simplified, universal nomenclature for DC types (2010: Immunol Rev, Eur J Immunol, Blood), which contributed to inform the current designation of human CD141+ and murine CD8α/CD103+ DC as type 1 conventional DC (cDC1).
*Identification of XCR1 as a specific marker of cDC1, linked to their terminal differentiation and interaction with cytotoxic lymphocytes (2008: Genome Biol; 2010: J Exp Med; 2011: J Immunol; 2018: Cell Rep).
*Functional specialization of cDC1: induction of protective anti-tumor/antiviral immunity (2010 & 2016: J Exp Med; 2021: iScience, Clin Transl Immunol, Sci Immunol).
*Concept of homeostatic tolerogenic vs. immunogenic maturation of DCs (2014: EMBO J; 2018: Immunity; 2025: Immunol Rev).
*In vitro generation and genetic manipulation of human cDC1 and pDC from hematopoietic stem cells (2014: J Immunol; 2018: Cell Rep; 2023: bioRxiv).
Honors and awards
2012-17: Grantee from the European Research Council, ERC Starting Grant “SystemsDendritic”.
2007: CNRS Bronze Medalist (https://www.cnrs.fr/sites/default/files/download-file/DalodM.pdf).
2004-9: Grantee from CNRS ATIPE to develop an independent research team.
Actualités

L’équipe de Marc Dalod du CIML démontre que certaines cellules immunitaires spécialisées peuvent être néfastes plutôt que protectrices lors d’infections […]

Dans le cadre d’Octobre Rose, les recherches menées par Marc Dalod, directeur de recherche au CNRS et responsable d’équipe au […]
Projets
Project : PLBIO 2024 Coordinateur: Thierry Walzer, CIRI, Lyon. Autre participant: Nathalie Bendriss-Vermare, CRCL, Lyon. Résumé: Les cellules Natural Killer […]

Project : ACLAMADABREC En partie via leur efficacité à activer les cellules natural killer (NK) et les lymphocyte T CD8 […]

Project : MITI Autres participants: Magali Richard, LIG, Grenoble; Lionel Spinelli, hub CB2M du CIML. Résumé: Ce projet vise à […]

Project : UNFIRE Autres participants: Ciphe (Ana Zarubica), Hospices Civils de Lyon et CIRI (Sophie Trouillet-Assant, Thierry Walzer), équipe CoVir […]




Project : DCFUNDEVSCREEN Résumé: Des études chez la souris ont montré le rôle clé antiviral/tumoral des cellules dendritiques, plasmacytoïdes (pDCs) […]

Project : RIPIREVI Autres participants: CIPHE (Ana Zarubica et collègues). Résumé: Les interférons de type I (IFN-Is) sont essentiels à […]


Project : NRegSkin Porteur: Mei LI (IGBMC, Strasbourg). Autres participants: Katia Boniface, Julien Seneschal (Université de Bordeaux). Résumé: La peau […]

Project : REVOLUTION Coordinateur: Edouard Sage, Hôpital Foch, Suresnes. Autres partenaires: Isabelle Schwartz-Cornil, INRAE, Jouy-en-Josas; Jérémie Pourchez, Ecole des Mines […]

Project : PLBIO 2021 Coordinateur: Christophe CAUX, CRCL, Lyon. Autres participants: Alain Viari, Inria, Lyon; Nathalie Bendriss-Vermare, CRCL, Lyon. Comment […]

Project : DECITIP Les cellules dendritiques plasmacytoides (pDCs) excellent dans la production des interférons de type I et III (IFN), […]


Project : pDCComp Les individus infectés par des virus ou souffrant de maladies inflammatoires développent un ensemble de troubles comportementaux […]



