How aging compromises antiviral defenses: a role for imbalanced innate cytokine production.

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Thème

Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS.

MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages.

Publié dans: Cell Host Microbe 2009 Nov; 6(5): 397-9

Auteurs: Rachel Guiton, Marc Dalod

Résumé

Aging causes enhanced susceptibility to viral infections. Stout-Delgado et al. (2009) report increased IL-17A production but reduced type I interferon levels in old mice infected by herpes viruses. This imbalance between proinflammatory and antiviral innate cytokine responses causes immunopathology and compromises virus control, which together lead to death by liver failure.

Lien vers Pubmed [PMID] – 19917493

Lien vers HAL – hal-00439894

Lien vers le DOI – 10.1016/j.chom.2009.10.008