Publication: BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells.

Publié dans: Blood 2011 Jul; 118(3): 609-17

Auteurs: Axel Defays, Alexandre David, Aude de Gassart, Francesca de Angelis Rigotti, Till Wenger, Voahirana Camossetto, Pierre Brousset, Tony Petrella, Marc Dalod, Evelina Gatti, Philippe Pierre

Résumé

The brain and dendritic cell (BAD)-associated lysosome-associated membrane protein (LAMP)-like molecule (BAD-LAMP, c20orf103, UNC-46) is a newly identified member of the family of LAMPs. BAD-LAMP expression in the mouse is confined to neurons. We demonstrate here that in humans, BAD-LAMP can specifically be found in the type I IFN-producing plasmacytoid dendritic cells (pDCs). Human BAD-LAMP is localized in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of freshly isolated CD123(+) pDCs and is rapidly lost upon activation by unmethylated cytosine-phosphate-guanine (CpG) oligonucleotides. The restricted pattern of BAD-LAMP expression allows for the rapid identification of normal and leukemic human pDCs in tissues and blood.

Lien vers Pubmed [PMID] – 21642595

Lien vers HAL – hal-00611405

Lien vers le DOI – 10.1182/blood-2010-11-319699