Développement du système immunitaire – CIML

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Theme

Integrative biology of T cells

Dendritic cell biology

Members

Serge VAN DE PAVERT

Research Officer

Oumaima BELMOURABIT

Jerome BELOUGNE

Assistant Engineer

Research Officer

Research Director

Research Engineer

Morgane CHAUVET

Christopher MAZZERBO

About

The immune system is established during embryonic life and the neonatal period according to a succession of finely coordinated events. Key players in this construction are the innate lymphoid cells (ILCs), specifically Lymphoid tissue inducer cells (LTi). These lymphocytes interact with “organizer” stromal cells to initiate and organize the development of lymph nodes during embryogenesis.

At Marseille–Luminy Immunology Center (CIML), Serge van de Pavert's lab studies how ILCs contribute to the development and maturation of the immune system in vivo. We explore how very early developmental signals — maternal environment, nutrients And neural signals — will influence the effectiveness of the immune system throughout life. Our approach combines mouse genetics, functional disruptions, advanced microscopy and 3D image analysis.

SPlab June 5, 2025

Research axes

Development and functions of ILCs in embryonic tissues and during the neonatal and postnatal period
Cellular and molecular control of lymph node organogenesis
Influence of the maternal environment (diet and metabolic signals) on the development of the immune system
Role of neuro-immune interactions in tissue organization
Volumetric imaging and computational morphometry 3D

Approaches & methods

Murine genetics, lineage and cell tracing
Functional disturbances in vivo (conditional/temporal control)
Tissue clarification, confocal/light sheet microscopy, volume reconstructions
Single-cell transcriptomics
Pipelines of3D image analysis and quantitative modeling

Team & Collaborations

We collaborate closely with partners in immunology, neurobiology, and computation to connect mechanisms at multiple scales—from transcriptional networks to organ morphogenesis.

“Immunofluorescent staining of a complete mouse E13.5 embryo reveals neurons (labeled with BetaIII Tubulin), macrophages and lymphatic endothelial cells in red (labeled with Lyve-1), the nuclei of specific neurons and lymphatic endothelial cells are marked in blue (Prox1 labeling) and the vascular network in white (Pecam-1 labeling). The eye of the embryo and the nasal neurons can be seen in green. On the left, the spinal cord is marked in green. The vertebrae are visible through the marking of the dorsal root ganglia in green, and blood vessels marked in white. The heart is visible just above the liver which is labeled with LYVE-1 antibody. The embryonic intestine, not far from the liver, is visualized by the innervation of neurons in green. be modified by changing certain dietary factors affecting cell differentiation. These visualizations are therefore intended to analyze the movements of cells involved in the formation of the lymphatic system.” Image Serge van de Pavert/CIML.

Projects

Project: SensoSkin Apical extracellular matrix (aECM) shapes and protects the epithelium in all organisms. We previously showed that like […]

Neural control of embryonic lymph node development

Amidex Project: ELNINo We analyze how neuronal signals integrate with immune and stromal programs to orchestrate ganglion organogenesis. In […]

Serge VAN DE PAVERT

The role of the maternal diet in embryonic immune system development

Project: CholControl You are what your mother ate Transgenerational impact of maternal diets via the regulation of RORγt activity […]

Serge VAN DE PAVERT

Equipments

Lightsheet Miltenyi Blaze

See details here: https://forge.inrae.fr/imagimm/equipment/-/wikis/Lightsheet

Publications

Serge A. van de Pavert, Daniela Talarico, Andrea Brendolan, Origin and differentiation of lymph node and spleen progenitors during embryonic development, Development (2025) 152 (15): dev204885..

Bavais J, Chevallier J, Spinelli L, van de Pavert SA, Puthier D, SciGeneX: enhancing transcriptional analysis through gene module detection in single-cell and spatial transcriptomics data. NAR Genom Bioinform 2025 Jun; 7(2): lqaf043.

Brouilly N, Pujol N, Richard F, Cazevieille C, Stone J, Eatock RA, Pujol R, A novel membrane contact site in vestibular hair cells. bioRxiv 2025 Mar; (): .

Sonntag T, Omi S, Andreeva A, Valotteau C, Eichelbrenner J, Chisholm AD, Ward JD, Pujol N, A defining member of the new cysteine-cradle family is an aECM protein signaling skin damage in C. elegans. PLoS Genet 2025 Mar; 21(3): e1011593.

Chauvet M, Bourges D, Scotet E, From ex vivo to in vitro models: towards a novel approach to investigate the efficacy of immunotherapies on exhausted Vγ9Vδ2 T cells?, Front Immunol 2025; 16(): 1556982.

Guen VJ, André-Grégoire G, Beauvillain C, Boury F, Chauvet M, Dupuy AMM, Fonteneau JF, Gagne K, Ga..., CRCI2NA inaugural symposium: A meeting on tumor and immune ecosystems. Biol Cell 2024 Dec; 116(12): e2400111.

Pooranachithra M, Jyo EM, Brouilly N, Pujol N, Ernst AM, Chisholm AD, C. elegans epiculins define specific compartments in the apical extracellular matrix and function in wound repair. Development 2024 Nov; 151(21): .

Snacel-Fazy E, Soubéran A, Grange M, Joseph K, Colin C, Morando P, Luche H, Pagano A, Brustlein S, ..., SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment. Cell Death Dis 2024 Sep; 15(9): 676.

Sundaram MV, Pujol N, The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo. Genetics 2024 Aug; 227(4): .

Pagneux Q, Garnier N, Fabregue M, Sharkaoui S, Mazzoli S, Engelmann I, Boukherroub R, Strecker M, Cr..., Neutralization of SARS-CoV-2 and Intranasal Protection of Mice with a nanoCLAMP Antibody Mimetic. ACS Pharmacol Transl Sci 2024 Mar; 7(3): 757-770.

Siret C, van de Pavert SA, Three-Dimensional Imaging of Macrophages in Complete Organs. Methods Mol Biol 2024; 2713(): 297-306.

Lola Boutin, Clement Barjon, Morgane Chauvet, Laura Lafrance, Eric Senechal, Dorothée Bourges, Emma..., Camelid‐derived T cell engages harnessing human γδ T cells as promising antitumor immunotherapeutic agents, <i>European Journal of Immunology</i>, In press, <a target="_blank" href="https://dx.doi.org/10.1002/eji.202350773">⟨10.1002/eji.202350773⟩</a>.

Weng JW, Park H, Valotteau C, Chen RT, Essmann CL, Pujol N, Sternberg PW, Chen CH, Body stiffness is a mechanical property that facilitates contact-mediated mate recognition in Caenorhabditis elegans. Curr Biol 2023 Sep; 33(17): 3585-3596.e5.

van de Pavert SA, Layered origins of lymphoid tissue inducer cells. Immunol Rev 2023 May; 315(1): 71-78.

Rejane Rua, Nathalie Pujol, Pathogen metabolite checkpoint: NHR on guard, <i>Immunity</i>, 2023, 56 (4), pp.744-746. <a target="_blank" href="https://dx.doi.org/10.1016/j.immuni.2023.03.004">⟨10.1016/j.immuni.2023.03.004⟩</a>.

Aggad D, Brouilly N, Omi S, Essmann CL, Dehapiot B, Savage-Dunn C, Richard F, Cazevieille C, Politi ..., Meisosomes, folded membrane microdomains between the apical extracellular matrix and epidermis. Elife 2023 Mar; 12(): .

Wang S, de Fabritus L, Kumar PA, Werner Y, Ma M, Li D, Siret C, Simic M, Li B, Kerdiles YM, Hou L, S..., Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke. J Neuroinflammation 2023 Jan; 20(1): 8.

Guillot J, Dominici C, Lucchesi A, Nguyen HTT, Puget A, Hocine M, Rangel-Sosa MM, Simic M, Nigri J, ..., Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer. Nat Commun 2022 Apr; 13(1): 1985.

Lenti E, Genovese L, Bianchessi S, Maurizio A, Sain SB, di Lillo A, Mattavelli G, Harel I, Bernassol..., Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors. Immunity 2022 Apr; 55(4): 606-622.e6.

Pujol N, Ewbank JJ, C. elegans: out on an evolutionary limb. Immunogenetics 2022 Feb; 74(1): 63-73.

Bobe S, Beckmann D, Klump DM, Dierkes C, Kirschnick N, Redder E, Bauer N, Schäfers M, Erapaneedi R,..., Volumetric imaging reveals VEGF-C-dependent formation of hepatic lymph vessels in mice. Front Cell Dev Biol 2022; 10(): 949896.

Wang S, van de Pavert SA, Innate Lymphoid Cells in the Central Nervous System. Front Immunol 2022; 13(): 837250.

Martineau CN, Maynard CA, Pujol N, ATFS-1 plays no repressive role in the regulation of epidermal immune response. MicroPubl Biol 2022; 2022(): .

Ting Wang, Zheng Wang, Lauriane de Fabritus, Jinglian Tao, Essa Saied, Ho-Joon Lee, Bulat Ramazanov,..., 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development, <i>Developmental Cell</i>, 2021, 56 (22), pp.3128-3145.e15. <a target="_blank" href="https://dx.doi.org/10.1016/j.devcel.2021.10.018">⟨10.1016/j.devcel.2021.10.018⟩</a>.

Zhang X, Harding BW, Aggad D, Courtine D, Chen JX, Pujol N, Ewbank JJ, Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defenses. PLoS Genet 2021 Jun; 17(6): e1009600.

Omi S, Zhang X, Thakur N, Pujol N, ifas-1 is upregulated by fungal infection in a GPA-12 and STA-2-independent manner in the Caenorhabditis elegans epidermis. MicroPubl Biol 2021 May; 2021(): .

van de Pavert SA, Lymphoid Tissue inducer (LTi) cell ontogeny and functioning in embryo and adult. Biomed J 2021 Apr; 44(2): 123-132.

Spanier B, Laurençon A, Weiser A, Pujol N, Omi S, Barsch A, Korf A, Meyer SW, Ewbank JJ, Paladino F..., Comparison of lipidome profiles of Caenorhabditis elegans-results from an inter-laboratory ring trial. Metabolomics 2021 Feb; 17(3): 25.

Sinner MP, Masurat F, Ewbank JJ, Pujol N, Bringmann H, Innate Immunity Promotes Sleep through Epidermal Antimicrobial Peptides. Curr Biol 2021 Feb; 31(3): 564-577.e12.

Omi S, Pujol N, unc-119 mutants have an increased fungal spore adhesion that is not rescued by Cb-unc-119. MicroPubl Biol 2021 Jan; 2021(): .

Martineau CN, Kirienko NV, Pujol N, Innate immunity in C. elegans. Curr Top Dev Biol 2021; 144(): 309-351.

Réjane Rua, Nathalie Pujol, IL-17: good fear no tears, <i>Nature Immunology</i>, 2020, 21 (11), pp.1315-1316. <a target="_blank" href="https://dx.doi.org/10.1038/s41590-020-0792-4">⟨10.1038/s41590-020-0792-4⟩</a>.

Watts JS, Harrison HF, Omi S, Guenthers Q, Dalelio J, Pujol N, Watts JL, New Strains for Tissue-Specific RNAi Studies in Caenorhabditis elegans. G3 (Bethesda) 2020 Nov; 10(11): 4167-4176.

Simic M, Manosalva I, Spinelli L, Gentek R, Shayan RR, Siret C, Girard-Madoux M, Wang S, de Fabritus..., Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny, Cell Rep 2020 Aug; 32(6): 108004.

Taffoni C, Omi S, Huber C, Mailfert S, Fallet M, Rupprecht JF, Ewbank JJ, Pujol N, Microtubule plus-end dynamics link wound repair to the innate immune response. Elife 2020 Jan; 9(): .

Theissen A, Pujol N, Raspado O, Slim K, [“Hospital hotels”: One more step towards short stay and ambulatory surgery]. Med Press 2019 Mar; 48(3 Pt 1): 219-222.

Omi S, Pujol N, Inducible expression of F48C1.9 encoding a nematode specific secreted peptide in the adult epidermis upon Drechmeria fungal infection. MicroPubl Biol 2019 Feb; 2019(): .

Siret C, Collignon A, Silvy F, Robert S, Cheyrol T, André P, Rigot V, Iovanna J, van de Pavert S, L..., Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma. Front Immunol 2019; 10(): 3070.

Lee SH, Omi S, Thakur N, Taffoni C, Belougne J, Engelmann I, Ewbank JJ, Pujol N, Modulatory upregulation of an insulin peptide gene by different pathogens in C. elegans. Virulence 2018 Dec; 9(1): 648-658.

Abe P, Wüst HM, Arnold SJ, van de Pavert SA, Stumm R, CXCL12-mediated feedback from granule neurons regulates generation and positioning of new neurons in the dental gyrus. Glia 2018 Aug; 66(8): 1566-1576.

Polanowska J, Chen JX, Soulé J, Omi S, Belougne J, Taffoni C, Pujol N, Selbach M, Zugasti O, Ewbank..., Evolutionary plasticity in the innate immune function of Akirin. PLoS Genet 2018 Jul; 14(7): e1007494.

Dodd W, Tang L, Lone JC, Wimberly K, Wu CW, Consalvo C, Wright JE, Pujol N, Choe KP, A Damage Sensor Associated with the Cuticle Coordinates Three Core Environmental Stress Responses in Caenorhabditis elegans. Genetics 2018 Apr; 208(4): 1467-1482.

EL, Zhou T, Koh S, Chuang M, Sharma R, Pujol N, Chisholm AD, Eroglu C, Matsunami H, Yan D, An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. Neuron 2018 Jan; 97(1): 125-138.e5.

Carolyn A. Thomson, Serge A. van De Pavert, Michelle Stakenborg, Evelien Labeeuw, Gianluca Matteoli,..., Expression of the A Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators, <i>Journal of Immunology</i>, 2018, 201 (1), pp.215-229. <a target="_blank" href="https://dx.doi.org/10.4049/jimmunol.1700967">⟨10.4049/jimmunol.1700967⟩</a>.

Karpanen T, Padberg Y, van de Pavert SA, Dierkes C, Morooka N, Peterson-Maduro J, van de Hoek G, Adr..., An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circ Res 2017 Apr; 120(8): 1263-1275.

Kim KW, Thakur N, Piggott CA, Omi S, Polanowska J, Jin Y, Pujol N, Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development. BMC Biol 2016 Dec; 14(1): 104.

Eric Vivier, Serge A. van De Pavert, Max D. Cooper, Gabrielle T. Belz, The evolution of innate lymphoid cells, <i>Nature Immunology</i>, 2016, 17 (7), pp.790-794. <a target="_blank" href="https://dx.doi.org/10.1038/ni.3459">⟨10.1038/ni.3459⟩</a>.

Zugasti O, Thakur N, Belougne J, Squiban B, Kurz CL, Soulé J, Omi S, Tichit L, Pujol N, Ewbank JJ, A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. BMC Biol 2016 Apr; 14(): 35.

Ewbank JJ, Pujol N, Local and long-range activation of innate immunity by infection and damage in C. elegans. Curr Opin Immunol 2016 Feb; 38(): 1-7.

Serge A. van De Pavert, Eric Vivier, Differentiation and function of group 3 innate lymphoid cells, from embryo to adult, <i>International Immunology</i>, 2016, 28 (1), pp.35-42. <a target="_blank" href="https://dx.doi.org/10.1093/intimm/dxv052">⟨10.1093/intimm/dxv052⟩</a>.

Pujol N, Virulence profile: Nathalie Pujol., Virulence 2016; 7(1): 63-4.

Santori FR, Huang P, van de Pavert SA, Douglass EF, Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konij..., Identification of natural RORγ ligands that regulate the development of lymphoid cells. Cell Metab 2015 Feb; 21(2): 286-298.

FR Santori, P. Huang, SA van de Pavert, EFJ Douglass, DJ Leaver, BA Haubrich, R. Keber, G..., Identification of Natural RORy ligands that Regulate the Development of Lymphoid Cells, Cell Metabolism , 2015, 21 (2), pp.386-97.

Taffoni C, Pujol N, Mechanisms of innate immunity in C. elegans epidermis. Tissue Barriers 2015; 3(4): e1078432.

Burger NB, Stuurman KE, Kok E, Konijn T, Schooneman D, Niederreither K, Coles M, Agace WW, Christoff..., Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency. Prenat Diagn 2014 Dec; 34(13): 1312-9.

Thakur N, Pujol N, Tichit L, Ewbank JJ, Clone mapper: an online suite of tools for RNAi experiments in Caenorhabditis elegans. G3 (Bethesda) 2014 Sep; 4(11): 2137-45.

Zugasti O, Bose N, Squiban B, Belougne J, Kurz CL, Schroeder FC, Pujol N, Ewbank JJ, Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans. Nat Immunol 2014 Sep; 15(9): 833-8.

Rouger V, Bordet G, Couillault C, Monneret S, Mailfert S, Ewbank JJ, Pujol N, Marguet D, Independent synchronized control and visualization of interactions between living cells and organisms. Biophys J 2014 May; 106(10): 2096-104.

van de Pavert SA, Ferreira M, Domingues RG, Ribeiro H, Molenaar R, Moreira-Santos L, Almeida FF, Ibi..., Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature 2014 Apr; 508(7494): 123-7.

van de Pavert SA, Mebius RE, Development of secondary lymphoid organs in relation to lymphatic vasculature. Adv Anat Embryol Cell Biol 2014; 214(): 81-91.

Ward JD, Mullaney B, Schiller BJ, He LD, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, ..., Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses. PLoS One 2014;9(3):e92552.

Kagoshima H, Cassata G, Tong YG, Pujol N, Niklaus G, Bürglin TR, The LIM homeobox gene ceh-14 is required for phasmid function and neurite outgrowth. Dev Biol 2013 Aug; 380(2): 314-23.

Pujol N, Davis PA, Ewbank JJ, The Origin and Function of Anti-Fungal Peptides in C. elegans: Open Questions. Front Immunol 2012; 3(): 237.

Labed SA, Omi S, Gut M, Ewbank JJ, Pujol N, The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression. PLoS One 2012;7(3):e33887.

Dierking K, Polanowska J, Omi S, Engelmann I, Gut M, Lembo F, Ewbank JJ, Pujol N, Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity. Cell Host Microbe 2011 May; 9(5): 425-35.

van de Pavert SA, Mebius RE, New insights into the development of lymphoid tissues. Nat Rev Immunol 2010 Sep; 10(9): 664-74.

Jaissle GB, May CA, van de Pavert SA, Wenzel A, Claes-May E, Giessl A, Szurman P, Wolfrum U, Wijnhol..., Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model. Graefes Arch Clin Exp Ophthalmol 2010 Aug; 248(8): 1063-70.

Ewbank JJ, Pujol N, Cellular homeostasis: coping with ER overload during an immune response. Curr Biol 2010 May; 20(10): R452-5.

Engelmann I, Pujol N, Innate immunity in C. elegans. Adv Exp Med Biol 2010; 708(): 105-21.

Lee KZ, Kniazeva M, Han M, Pujol N, Ewbank JJ, The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis. Virulence 2010; 1(3): 113-22.

van de Pavert SA, Olivier BJ, Goverse G, Vondenhoff MF, Greuter M, Beke P, Kusser K, Höpken UE, Lip..., Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat Immunol 2009 Nov; 10(11): 1193-9.

Fischer MD, Huber G, Beck SC, Tanimoto N, Muehlfriedel R, Fahl E, Grimm C, Wenzel A, Remé CE, van d..., Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PLoS One 2009 Oct; 4(10): e7507.

Drennan MB, Franki AS, Dewint P, Van Beneden K, Seeuws S, van de Pavert SA, Reilly EC, Verbruggen G,..., Cutting edge: the chemokine receptor CXCR3 retains invariant NK T cells in the thymus. J Immunol 2009 Aug; 183(4): 2213-6.

Ziegler K, Pujol N, [C. elegans defense mechanisms]. Med Sci (Paris) 2009 May; 25(5): 497-503.

Ziegler K, Kurz CL, Cypowyj S, Couillault C, Pophillat M, Pujol N, Ewbank JJ, Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Cell Host Microbe 2009 Apr; 5(4): 341-52.

Tong A, Lynn G, Ngo V, Wong D, Moseley SL, Ewbank JJ, Goncharov A, Wu YC, Pujol N, Chisholm AD, Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase. Proc Natl Acad Sci USA 2009 Feb; 106(5): 1457-61.

Vondenhoff MF, van de Pavert SA, Dillard ME, Greuter M, Goverse G, Oliver G, Mebius RE, Lymph sacs are not required for the initiation of lymph node formation. Development 2009 Jan; 136(1): 29-34.

Pujol N, Zugasti O, Wong D, Couillault C, Kurz CL, Schulenburg H, Ewbank JJ, Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides. PLoS Pathog 2008 Jul; 4(7): e1000105.

Pujol N, Cypowyj S, Ziegler K, Millet A, Astrain A, Goncharov A, Jin Y, Chisholm AD, Ewbank JJ, Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr Biol 2008 Apr; 18(7): 481-9.

van de Pavert SA, Sanz AS, Aartsen WM, Vos RM, Versteeg I, Beck SC, Klooster J, Seeliger MW, Wijnhol..., Crb1 is a determinant of retinal apical Müller glia cell features. Glia 2007 Nov; 55(14): 1486-97.

Pradel E, Zhang Y, Pujol N, Matsuyama T, Bargmann CI, Ewbank JJ, Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegans., Proc Natl Acad Sci USA 2007 Feb; 104(7): 2295-300.

van de Pavert SA, Meuleman J, Malysheva A, Aartsen WM, Versteeg I, Tonagel F, Kamphuis W, McCabe CJ,..., A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1. J Neurosci 2007 Jan; 27(3): 564-73.

Wong D, Bazopoulou D, Pujol N, Tavernarakis N, Ewbank JJ, Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol 2007; 8(9): R194.

Aartsen WM, Kantardzhieva A, Klooster J, van Rossum AG, van de Pavert SA, Versteeg I, Cardozo BN, To..., Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Hum Mol Genet 2006 Apr; 15(8): 1291-302.

Seeliger MW, Beck SC, Pereyra-Muñoz N, Dangel S, Tsai JY, Luhmann UF, van de Pavert SA, Wijnholds J..., In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy. Vision Res 2005 Dec; 45(28): 3512-9.

Cardoso C, Couillault C, Mignon-Ravix C, Millet A, Ewbank JJ, Fontés M, Pujol N, XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans. Dev Biol 2005 Feb; 278(1): 49-59.

Mathias Seeliger, Susanne Beck, Naira Pereyra-Muñoz, Susann Dangel, Jen-Yue Tsai, Ulrich Luhmann, S..., In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy, <i>Vision Research</i>, 2005, 45 (28), pp.3512-3519. <a target="_blank" href="https://dx.doi.org/10.1016/j.visres.2005.08.014">⟨10.1016/j.visres.2005.08.014⟩</a>.

Meuleman J, van de Pavert SA, Wijnholds J, Crumbs homolog 1 in polarity and blindness. Biochem Soc Trans 2004 Nov; 32(Pt 5): 828-30.

van de Pavert SA, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, Klooster J, Geiger..., Crumbs homolog 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci 2004 Aug; 117(Pt 18): 4169-77.

Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ, TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adapter protein TIR-1, an ortholog of human MRSA. Nat Immunol 2004 May; 5(5): 488-94.

SA van de Pavert, A. Kantardzhieva, A. Malysheva, J. Meuleman, I. Versteeg, C. Levelt, J. Klooster..., Crumbs homolog 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure, Journal of Cell Science , 2004, 117, pp.4169-4177.

Pujol N, Ewbank JJ, [A worm's life]., Med Sci (Paris) 2003 Dec; 19(12): 1209-17.

Mallo GV, Kurz CL, Couillault C, Pujol N, Granjeaud S, Kohara Y, Ewbank JJ, Inducible antibacterial defense system in C. elegans. Curr Biol 2002 Jul; 12(14): 1209-14.

Stringham E, Pujol N, Vandekerckhove J, Bogaert T, unc-53 controls longitudinal migration in C. elegans. Development 2002 Jul; 129(14): 3367-79.

Terranova R, Pujol N, Fasano L, Djabali M, Characterization of set-1, a conserved PR/SET domain gene in Caenorhabditis elegans. Gene 2002 Jun; 292(1-2): 33-41.

van den Hurk R, Van de Pavert SA, Localization of an activin/activin receptor system in the porcine ovary. Mol Reprod Dev 2001 Dec; 60(4): 463-71.

van de Pavert SA, Boerjan ML, Stroband HW, Taverne MA, van den Hurk R, Uterine-embryonic interaction in pig: activin, follistatin, and activin receptor II in uterus and embryo during early gestation. Mol Reprod Dev 2001 Aug; 59(4): 390-9.

van de Pavert SA, Schipper H, de Wit AA, Soede NM, van den Hurk R, Taverne MA, Boerjan ML, Stroband ..., Comparison of anterior-posterior development in the porcine versus chicken embryo, using goosecoid expression as a marker. Reprod Fertil Dev 2001; 13(2-3): 177-85.

Meijer HA, Van De Pavert SA, Stroband HW, Boerjan ML, Expression of the organizer specific homeobox gene goosecoid (gsc) in porcine embryos. Mol Reprod Dev 2000 Jan; 55(1): 1-7.

Schwartz J, Van de Pavert S, Clarke I, Rao A, Ray D, Vrana K, Paracrine interactions within the pituitary gland. Ann NY Acad Sci 1998 May; 839(): 239-43.

van de Pavert SA, Clarke IJ, Rao A, Vrana KE, Schwartz J, Effects of vasopressin and elimination of corticotropin-releasing hormone-target cells on pro-opiomelanocortin mRNA levels and adrenocorticotropin secretion in ovine anterior pituitary cells. J Endocrinol 1997 Jul; 154(1): 139-47.

Funding