Publication: Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development

Published in: Immunity, 2023, 57, pp.86 - 105.e9. ⟨10.1016/j.immuni.2023.12.002⟩

Authors: Erica Tagliatti, Genni Desiato, Sara Mancinelli, Matteo Bizzotto, Maria C Gagliani, Elisa Faggiani, Rebeca Hernández-Soto, Andrea Cugurra, Paola Poliseno, Matteo Miotto, Rafael J Argüello, Fabia Filipello, Katia Cortese, Raffaella Morini, Simona Lodato, Michela Matteoli

Summary

Lack of Trem2 in mice impairs hippocampal neuronal bioenergetics during development d CA1 but not CA3 neurons show reduced mitochondrial mass and metabolism d CA1 metabolic dysfunction is later accompanied by synaptic and network alterations d A partial reduction in Trem2 is sufficient to alter neuronal metabolic fitness

Link to HAL – amu-04743965

Link to DOI – 10.1016/j.immuni.2023.12.002