Published in: Cytokine Growth Factor Rev 2010 Feb; 21(1): 61-5
Authors: Rodriguez-Vita J, Lawrence T
Summary
Inflammation has long been thought to contribute to the development of cancer; however there is also clear evidence that the immune system can recognize and eliminate cancer cells. Current research suggests that cancer-associated inflammation has a dual role in tumor progression; inflammatory mediators promote the malignant activity of cancer cells by acting as growth factors and also stimulate angiogenesis, however, cancer-associated inflammation is also linked with immune-suppression that allows cancer cells to evade detection by the immune system. In this review we will discuss the dual role of inflammation in cancer and how endogenous anti-inflammatory mechanisms may equally be important in carcinogenesis.
Link to Pubmed [PMID] – 20022797
Link to HAL – hal-00553068
Link to DOI – 10.1016/j.cytogfr.2009.11.006