
Publication: Role of meningeal immunity in brain function and protection against pathogens
Published in: Journal of Inflammation, 2024, 21 (1), pp.3. ⟨10.1186/s12950-023-00374-7⟩
Authors: Julie Rebejac, Elisa Eme-Scolan, Rejane Rua
Summary
The brain and spinal cord collectively referred to as the Central Nervous System (CNS) are protected by the blood-brain barrier that limits molecular, microbial and immunological trafficking. However, in the last decade, many studies have emphasized the protective role of ‘border regions’ at the surface of the CNS which are highly immunologically active, in contrast with the CNS parenchyma. In the steady-state, lymphoid and myeloid cells residing in the cranial meninges can affect brain function and behavior. Upon infection, they provide a first layer of protection against microbial neuroinvasion. The maturation of border sites over time enables more effective brain protection in adults as compared to neonates. Here, we provide a comprehensive update on the meningeal immune system and its role in physiological brain function and protection against infectious agents.
Link to Pubmed [PMID] – 38291415
Link to HAL – hal-04946143
Link to DOI – 10.1186/s12950-023-00374-7