Publication: Pathogen metabolite checkpoint: NHR on guard

Published in: Immunity, 2023, 56 (4), pp.744-746. ⟨10.1016/j.immuni.2023.03.004⟩

Authors: Rejane Rua, Nathalie Pujol

Summary

How can beneficial microorganisms be distinguished from pathogenic ones? In their study, Peterson et al. discovered that a specific phenazine, which is part of a family of toxic metabolites expressed by pathogenic bacteria, is detected by Caenorhabditis elegans by directly binding to a nuclear hormone receptor, promoting the expression of detoxifying enzymes and immunity-related genes, thus protecting the worm (1).

Link to Pubmed [PMID] – 37044064

Link to HAL – hal-04204567

Link to DOI – 10.1016/j.immuni.2023.03.004