Publication: Monocyte immunometabolic reprogramming in human pregnancy: contribution of trophoblast cells

Published in: AJP - Endocrinology and Metabolism, 2024, 326 (3), pp.E215-E225. ⟨10.1152/ajpendo.00357.2023⟩

Authors: Fátima Merech, Soledad Gori, Guillermina Calo, Vanesa Hauk, Daniel Paparini, Daiana Rios, Brenda Lara, Luciana Doga, Luciana D’eramo, Aldo Squassi, Rosanna Ramhorst, Rafael Argüello, Claudia Pérez Leirós, Daiana Vota

Summary

Immunometabolism stands as a novel perspective to understand the complex regulation of the immune response and to provide small molecule-based therapies. By applying this approach to study monocytes during pregnancy, we found that these cells have a unique activation pattern. They rely more on glycolysis and show increased efferocytosis/IL-10 production, but they do not have the typical proinflammatory responses. We also present evidence that trophoblast cells can shape monocytes into this distinct immunometabolic profile.

Link to HAL – amu-04940254

Link to DOI – 10.1152/ajpendo.00357.2023