Publication: Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity

Published in: Current Opinion in Immunology, 2016, 38, pp.30-38. ⟨10.1016/j.coi.2015.10.005⟩

Authors: Philippe Naquet, Caroline Giessner, Franck Galland

Summary

Recent developments have demonstrated that metabolic rewiring imposed by adaptation of tissues to stress leads to the release of various metabolites which directly or indirectly impact innate immune responses and inflammation. Some metabolites can behave as second messengers and leave local cues in tissues. Immune cells which infiltrate stressed tissues reorient their metabolism to cope with these microenvironmental cues while preserving their effector functions in tissues.

Link to Pubmed [PMID] – 26605965

Link to HAL – hal-01438528

Link to DOI – 10.1016/j.coi.2015.10.005