Differentiation Paths of Peyer’s Patch LysoDCs Are Linked to Sampling Site Positioning, Migration, and T Cell Priming

Published in: Cell Rep 2020 Apr; 31(1): 107479

Authors: Camille Wagner, Johnny Bonnardel, Clément da Silva, Lionel Spinelli, Cynthia Arroyo Portilla, Julie Tomas, Margaux Lagier, Lionel Chasson, Marion Massé, Marc Dalod, Alexandre Chollat-Namy, Jean-Pierre Gorvel, Hugues Lelouard

Summary

Graphical Abstract Highlights d Peyer’s patch monocyte-derived LysoDCs follow two main differentiation pathways d One of the two LysoDC differentiation paths leads to acquisition of DC features d LysoDCs mature while getting closer to the epithelium d Mature LysoDCs migrate to the periphery of the T cell zones only when stimulated

Link to HAL – hal-02994226

Link to DOI – 10.1016/j.celrep.2020.03.043