Daredevil human cDC2s tame wild TSLP to promote tolerance.

Theme

JUN Specifies the Local Differentiation and Maintenance of Pro-tumoral Monocyte-Derived Macrophages.

[Unexpected detrimental role of plasmacytoid dendritic cells during viral infections of the lungs].

Published in: Immunity 2026 May; 59(5): 1165-1167

Authors: Lopez Hernandez A, Dalod M

Summary

Under homeostatic conditions, murine dendritic cells (DCs) undergo a tolerogenic activation termed homeostatic maturation, preventing autoimmunity by inducing tolerance to innocuous antigens; whether this process occurs in humans is unknown. In this issue of Immunity, Lu et al. report that splenic human type 2 DCs undergo homeostatic maturation under thymic stromal lymphopoietin (TSLP) instruction.

Link to Pubmed [PMID] – 42119363

Link to DOI – 10.1016/j.immuni.2026.04.010