Cellular homeostasis: coping with ER overload during an immune response.

Theme

Une pratique funéraire atypique pour l’âge du Bronze final en Lorraine (France)

Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death.

Published in: Curr Biol 2010 May; 20(10): R452-5

Authors: Ewbank JJ, Pujol N

Summary

Host cells secrete antimicrobial proteins en masse to counter extracellular pathogens, placing a strain on the endoplasmic reticulum. The interplay between defence and cellular homeostasis has now been dissected genetically in Caenorhabditis elegans.

Link to Pubmed [PMID] – 20504757

Link to DOI – 10.1016/j.cub.2010.03.023