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Project : CholControl

You are what your mother ate

Transgenerational impact of maternal diets via regulation of RORγt activity in embryonic and postnatal ILC3s

We study how maternal nutrition during pregnancy modulates the activity of RORγt in the ILC3 in development, influencing lymphoid tissue maturation and postnatal barrier immunity.
Collaboration: Pr Andreas Diefenbach (Charité, Berlin).
Financing: ANR PRCI

Publications

2010
van de Pavert SA, Mebius RE, New insights into the development of lymphoid tissues. Nat Rev Immunol 2010 Sep; 10(9): 664-74.
2014
van de Pavert SA, Ferreira M, Domingues RG, Ribeiro H, Molenaar R, Moreira-Santos L, Almeida FF, Ibi..., Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature 2014 Apr; 508(7494): 123-7.

Funding