MetaNiche (Spatial-SCENITH) Metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02). – CIML

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Theme

Biomarkers established to stratify sepsis long-term adverse effects to improve patients' survivorship (BEATsep)

Epic-SCENITH: regulators of metabolism and epigenetics in glioblastoma-associated myeloid cells

About

Bone marrow metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02).

Duration: 2023–2027 (42 months).
Partners & funding amounts: Institut Curie (L. Perié), Institut Pasteur (P. Bousso); amount for team: 208 k€.
Responsibilities: Co-PI.
Theme & content of work: Builds spatial immunometabolism tools to link niche-specific metabolites to myelopoiesis trajectories and early epigenetic programming underlying persistent immune dysfunction.
Scope & impact: Spatial/fate-resolved metabolism readouts in bone marrow; platform for predictive biomarkers and therapeutic targeting.

L’image actuelle n’a pas de texte alternatif. Le nom du fichier est : Spatial-SCENITH-metaNiche.png

Muliple collaborations for Spatial SCENITH (Rejane Rua lab, Achille Broggi Lab, Berengere Laval, Thomas Lecuit Lab, Neibla Priego and others)

Rafael ARGUELLO

Publications

Argüello RJ, Combes AJ, Char R, Gigan JP, Baaziz AI, Bousiquot E, Camosseto V, Samad B, Tsui J, Yan..., SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution. Cell Metab 2020 Dec; 32(6): 1063-1075.e7.

Vogel A, García González P, Argüello RJ, Measuring the Metabolic State of Tissue-Resident Macrophages via SCENITH. Methods Mol Biol 2024; 2713(): 363-376.

Sanne GS Verberk, Kyra E de Goede, Friederike S Gorki, Xanthe a MH van Dierendonck, Rafael J Argü..., A toolbox to profile immunometabolism tested in macrophages, 2021.

Funding