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CNRS – University of Melbourne Graduate Research Projects

The project investigates the molecular interplay between the E3-ubiquitin ligase MARCH1 and its partners in antigen-presenting cells, aiming to modulate immune responses for cancer immunotherapy and anti-inflammatory treatments. Using CRISPR/Cas9, high-resolution microscopy, “omics” technologies, and novel Protac/antibody strategies, we will dissect their regulation, trafficking, and functional impact on immunomodulation.

Co supervision with Pr. Justine Mintern , Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Australia.

Publications

2008
De Gassart A, Camosseto V, Thibodeau J, Ceppi M, Catalan N, Pierre P, Gatti E, MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc Natl Acad Sci USA 2008 Mar; 105(9): 3491-6.
2017
De Angelis Rigotti F, De Gassart A, Pforr C, Cano F, N'Guessan P, Combes A, Camossetto V, Lehner PJ,..., MARCH9-mediated ubiquitination regulates MHC I export from the TGN. Immunol Cell Biol 2017 Oct; 95(9): 753-764.
2008
Thibodeau J, Bourgeois-Daigneault MC, Huppé G, Tremblay J, Aumont A, Houde M, Bartee E, Brunet A, G..., Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Eur J Immunol 2008 May; 38(5): 1225-30.
2019
Gatti E, Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases. Methods Mol Biol 2019; 1988(): 259-270.

Funding