Project: Spatial mapping of gene expression to decipher thymic interactions controlling central immune tolerance

About

Project : ThymMap

T lymphocytes recognize pathogens while being tolerant to our
tissues. They differentiate in the thymus within niches composed of epithelial cells
thymic (TEC). TECs select developing T cells, which control
reciprocally the differentiation and organization of TECs. Defects in these interactions
bidirectional, called “crosstalk,” leads to autoimmune diseases. Studies
Recent single-cell RNA-seq studies have identified numerous TEC subtypes with
distinct functional properties. However, their spatial distribution and contribution to the
T cell tolerance remains unknown.

This spatial multi-omics project, at the interface between immunology and transcriptomics, aims to provide a comprehensive view of thymic interactions in physio-pathological conditions.