Virginie MILLET – CIML

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Virginie Millet, ingénieure en biologie cellulaire et moléculaire, a rejoint l’équipe d’Achille Broggi “Immunité innée au niveau des muqueuses” en 2022, où elle se spécialise dans l’étude des modèles d’organoïdes intestinaux.

Elle a auparavant consacré vingt années de recherche, aux côtés du Pr Philippe Naquet, à l’exploration des molécules Vanin et leur implication dans les maladies inflammatoires et le cancer.

Projects

Type IlI Interferons, master regulator of mucosal homeostasis. – INTERMUCOSAL

Project: INTERMUCOSAL This project explores the role of an immune system molecule called type III interferon (IFN-λ). This […]

Virginie MILLET

MetaNiche (Spatial-SCENITH) Metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02).

Bone marrow metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02). Duration: 2023–2027 (42 months).Partners & funding amounts: Institut Curie (L. Perié), Institut […]

Rafael J ARGUELLO

Publications

Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenou..., Type III interferons induce pyroptosis in gut epithelial cells and odd mucosal repair. Cell 2024 Dec; 187(26): 7533-7550.e23.

Richard Miallot, Virginie Millet, Anais Roger, Romain Fenouil, Catherine Tardivel, Jean-Charles Mart..., The coenzyme A precursor pantethine enhances antitumor immunity in sarcoma, <i>Life Science Alliance</i>, 2023, 6 (12), pp.e202302200. <a target="_blank" href="https://dx.doi.org/10.26508/lsa.202302200">⟨10.26508/lsa.202302200⟩</a>.

Richard Miallot, Virginie Millet, Franck Galland, Philippe Naquet, The vitamin B5/coenzyme A axis: A target for immunomodulation?, <i>European Journal of Immunology</i>, 2023, 53 (10), <a target="_blank" href="https://dx.doi.org/10.1002/eji.202350435">⟨10.1002/eji.202350435⟩</a>.

Miallot R, Millet V, Groult Y, Modelska A, Crescence L, Roulland S, Henri S, Malissen B, Brouilly N,..., An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity. Life Sci Alliance 2023 Jun; 6(6): .

Giessner C, Millet V, Mostert KJ, Gensollen T, Vu Manh TP, Garibal M, Dieme B, Attaf-Bouabdallah N, ..., Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity. Life Sci Alliance 2018 Aug; 1(4): e201800073.

Rommelaere S, Millet V, Gensollen T, Bourges C, Eeckhoute J, Hennuyer N, Baugé E, Chasson L, Caccia..., PPARalpha regulates the production of serum Vanin-1 by liver. FEBS Lett 2013 Nov; 587(22): 3742-8.

Pouyet L, Roisin-Bouffay C, Clément A, Millet V, Garcia S, Chasson L, Issaly N, Rostan A, Hofman P,..., Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model. Inflamm Bowel Dis 2010 Jan; 16(1): 96-104.

Millet V, Naquet P, Guinamard RR, Intercellular MHC transfer between thymic epithelial and dendritic cells., Eur J Immunol 2008 May; 38(5): 1257-63.

Carole Berruyer, Laurent Pouyet, Virginie Millet, Florent M Martin, Aude Legoffic, Alexandra Canonic..., Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. <i>Journal of Experimental Medicine</i>, 2006, 203 (13), pp.2817-27. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20061640">⟨10.1084/jem.20061640⟩</a>.

Noël D, Gazit D, Bouquet C, Apparailly F, Bony C, Plence P, Millet V, Turgeman G, Perricaudet M, Sa..., Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cells., Stem Cells 2004 ; 22(1): 74-85.

Perez N, Plence P, Millet V, Greuet D, Minot C, Noel D, Danos O, Jorgensen C, Apparailly F, Tetracycline transcriptional silencer tightly controls transgene expression after in vivo intramuscular electrotransfer: application to interleukin 10 therapy in experimental arthritis., Hum Gene Ther 2002 Dec; 13(18): 2161-72.

Apparailly F, Millet V, Noël D, Jacquet C, Sany J, Jorgensen C, Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis., Hum Gene Ther 2002 Jul; 13(10): 1179-88.