Sebastien JAEGER – CIML

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Dorian BOURGEON

About

Sébastien Jaeger is a senior research engineer at the CNRS, co-head of CB2M (Computational Biology, Biostatistics & Modeling). Initially trained in physics and applied mathematics (PhD in theoretical physics), he has more than twenty years of experience in computational biology and immunology, working at the interface between physics, mathematics, and biology (especially immunology). These interests are oriented towards mathematical modeling and fundamental biophysics. Coming from the field of dynamical systems in physics, he is particularly interested in dynamic phenomena in biology and explores immunological systems and issues through formal approaches.

Career

Energy Mechanics Engineer (IUSTI, now Polytech, 1999)

Doctorate in theoretical physics (Centre for theoretical physics in Marseille, 2002)

Postdoctorate in bioinformatics at the Laboratory of Genetics and Physiology of Development (LGPD) then at the Institute of Developmental Biology of Marseille (IBDM)

Research engineer at CIML (2005)

Recruitment as a statutory research engineer (CNRS) at CIML (2006)

Creation in 2009 of CB2M, of which he has been responsible since (co-responsible since 2025).

Projects

TCELL-CODE: Deciphering T cell activation through TCR stimulation dynamics

The TCELL-CODE project, coordinated by Dr. Rémy Lasserre at the Marseille Cancer Research Center, aims to elucidate […]

Guillaume VOISINNE

ST-omics: Structuring regional expertise in spatial transcriptomics

The ST-omics structuring action of the Cancéropôle de la Région Sud is co-coordinated by Dr Pierre Milpied (CIML), Prof Emmanuelle […]

Publications

Aussel R, Asif M, Chenag S, Jaeger S, Milpied P, Spinelli L, ShIVA: a user-friendly and interactive interface giving biologists control over their single-cell RNA-seq data. Sci Rep 2023 Sep; 13(1): 14377.

Crinier A, Milpied P, Escalière B, Piperoglou C, Galluso J, Balsamo A, Spinelli L, Cervera-Marzal I..., High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice. Immunity 2018 Nov; 49(5): 971-986.e5.

Xia F, Qian CR, Xun Z, Hamon Y, Sartre AM, Formisano A, Mailfert S, Phelipot MC, Billaudeau C, Jaege..., TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells. Front Immunol 2018; 9(): 2864.

Nardecchia I, Lechelon M, Gori M, Donato I, Preto J, Floriani E, Jaeger S, Mailfert S, Marguet D, Fe..., Detection of long-range electrostatic interactions between charged molecules by means of fluorescence correlation spectroscopy. Phys Rev E 2017 Aug; 96(2-1): 022403.

Castro-Mondragon JA, Jaeger S, Thieffry D, Thomas-Chollier M, van Helden J, RSAT matrix-clustering: dynamic exploration and redundancy reduction of transcription factor binding motif collections. Nucleic Acids Res 2017 Jul; 45(13): e119.

Dalet A, Argüello RJ, Combes A, Spinelli L, Jaeger S, Fallet M, Vu Manh TP, Mendes A, Perego J, Rev..., Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA. EMBO J 2017 Mar; 36(6): 761-782.

Medina-Rivera A, Defrance M, Sand O, Herrmann C, Castro-Mondragon JA, Delerce J, Jaeger S, Blanchet ..., RSAT 2015: Regulatory Sequence Analysis Tools. Nucleic Acids Res 2015 Jul; 43(W1): W50-6.

Navarro JM, Touzart A, Pradel LC, Loosveld M, Koubi M, Fenouil R, Le Noir S, Maqbool MA, Morgado E, ..., Site- and allele-specific polycomb dysregulation in T-cell leukaemia. Nat Commun 2015 Jan;6():6094.

Outters P, Jaeger S, Zaarour N, Ferrier P, Long-Range Control of V(D)J Recombination & Allelic Exclusion: Modeling Views. Adv Immunol 2015; 128(): 363-413.

Nardecchia I, Spinelli L, Preto J, Gori M, Floriani E, Jaeger S, Ferrier P, Pettini M, Experimental detection of long-distance interactions between biomolecules through their diffusion behavior: numerical study. Phys Rev E Stat Nonlin Soft Matter Phys 2014 Aug; 90(2): 022703.

Pradeu T, Jaeger S, Vivier E, The speed of change: towards a discontinuity theory of immunity? Nat Rev Immunol 2013 Oct; 13(10): 764-9.

Jaeger S, Fernandez B, Ferrier P, Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'. Immunology 2013 Jun; 139(2): 141-50.

Jia J, Pekowska A, Jaeger S, Benoukraf T, Ferrier P, Spicuglia S, Assessing the efficiency and significance of Methylated DNA Immunoprecipitation (MeDIP) assays in using in vitro methylated genomic DNA. BMC Res Notes 2010 Sep; 3(): 240.

Farcot E, Bonnet M, Jaeger S, Spicuglia S, Fernandez B, Ferrier P, TCR beta allelic exclusion in dynamical models of V(D)J recombination based on allele independence. J Immunol 2010 Aug; 185(3): 1622-32.

Bonnet M, Huang F, Benoukraf T, Cabaud O, Verthuy C, Boucher A, Jaeger S, Ferrier P, Spicuglia S, Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model. J Immunol 2009 Dec; 183(12): 7939-48.

Benoukraf T, Cauchy P, Fenouil R, Jeanniard A, Koch F, Jaeger S, Thieffry D, Imbert J, Andrau JC, Sp..., CoCAS: a ChIP-on-chip analysis suite. Bioinformatics 2009 Apr; 25(7): 954-5.

Franchini DM, Benoukraf T, Jaeger S, Ferrier P, Payet-Bornet D, Initiation of V(D)J recombination by Dbeta-associated recombination signal sequences: a critical control point in TCRbeta gene assembly. PLoS One 2009;4(2):e4575.

Daëron M, Jaeger S, Du Pasquier L, Vivier E, Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Immunol Rev 2008 Aug; 224(): 11-43.

Walzer T, Jaeger S, Chaix J, Vivier E, Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses. Curr Opin Immunol 2007 Jun; 19(3): 365-72.

Walzer T, Bléry M, Chaix J, Fuseri N, Chasson L, Robbins SH, Jaeger S, André P, Gauthier L, Daniel..., Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc Natl Acad Sci USA 2007 Feb; 104(9): 3384-9.