Marie-Claire BLACHE – CIML

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About

CNRS Study Engineer specializing in microscopy, I have been working on the ImagImm platform since January 2024. My training at the interface between biology and physics has led me to hold various positions in research institutes (CIML, IPBS, INRS Canada). In 2014, I joined the Cell Imaging Platform of INRAE Val de Loire, an experience that allowed me to develop the skills necessary for my current job.

My expertise is based on mastery of photon microscopy techniques (fluorescence, confocal, spectral, FCS, FRAP), image processing and analysis (ImageJ, QuPath, Imaris), as well as their automation via classic tools and artificial intelligence (Machine Learning and Deep Learning). I also provide user training in the use of the platform's equipment and image processing solutions.

I am an active member of the GT MAIIA (Working Group "Methods of Image Analysis by Artificial Intelligence") attached to the CNRS Multidimensional Fluorescence Microscopy Technology Network. This group aims to support platform staff in the use of Machine Learning (ML) and Deep Learning (DL) tools for image processing and analysis.

Publications

Court L, Talbottier L, Lemarchand J, Cornilleau F, Pecnard E, Blache MC, Balthazart J, Cornil CA, Ke..., Exploring neural markers and early social environment influence in divergent quail lines selected for social motivation. Sci Rep 2024 Oct; 14(1): 23554.

Graham S, Vu QD, Jahanifar M, Weigert M, Schmidt U, Zhang W, Zhang J, Yang S, Xiang J, Wang X, Rumbe..., CoNIC Challenge: Pushing the frontiers of nuclear detection, segmentation, classification and counting. Med Image Anal 2024 Feb; 92(): 103047.

Arnould C, Love SA, Piégu B, Lefort G, Blache MC, Parias C, Soulet D, Lévy F, Nowak R, Lansade L, ..., Facial blushing and feather fluffing are indicators of emotions in domestic fowl (Gallus gallus domesticus). PLoS One 2024; 19(7): e0306601.

Chevillard PM, Batailler M, Dubois JP, Estienne A, Pillon D, Vaudin P, Piégu B, Blache MC, Dupont J..., Seasonal remodeling of the progenitor pool and its distribution in the ewe mediobasal hypothalamus. Cell Tissue Res 2023 Jun; 392(3): 745-761.

Bertin A, Mulot B, Nowak R, Blache MC, Love S, Arnold M, Pinateau A, Arnould C, Lansade L, Captive Blue-and-yellow macaws (Ara ararauna) show facial indicators of positive affect when reunited with their caregiver. Behav Processes 2023 Mar; 206(): 104833.

Chevillard PM, Batailler M, Piégu B, Estienne A, Blache MC, Dubois JP, Pillon D, Vaudin P, Dupont J..., Seasonal vascular plasticity in the mediobasal hypothalamus of the adult ewe., Histochem Cell Biol 2022 May; 157(5): 581-593.

Alcântara-Neto AS, Schmaltz L, Caldas E, Blache MC, Mermillod P, Almiñana C, Porcine oviductal extracellular vesicles interact with gametes and regulate sperm motility and survival. Theriogenology 2020 Oct; 155(): 240-255.

Bertevello PS, Teixeira-Gomes AP, Labas V, Cordeiro L, Blache MC, Papillier P, Singina G, Uzbekov R,..., MALDI-TOF Mass Spectrometry Revealed Significant Lipid Variations in Follicular Fluid and Somatic Follicular Cells but Not in Enclosed Oocytes between the Large Dominant and Small Subordinate Follicles in Bovine Ovary. Int J Mol Sci 2020 Sep; 21(18): .

Ramal-Sanchez M, Bernabo N, Tsikis G, Blache MC, Labas V, Druart X, Mermillod P, Saint-Dizier M, Progesterone induces sperm release from oviductal epithelial cells by modifying sperm proteomics, lipidomics and membrane fluidity. Mol Cell Endocrinol 2020 Mar; 504(): 110723.

Bertin A, Cornilleau F, Lemarchand J, Boissy A, Leterrier C, Nowak R, Calandreau L, Blache MC, Boivi..., Are there facial indicators of positive emotions in birds? A first exploration in Japanese quail. Behav Processes 2018 Dec; 157(): 470-473.

Bertevello PS, Teixeira-Gomes AP, Seyer A, Vitorino Carvalho A, Labas V, Blache MC, Banliat C, Corde..., Lipid Identification and Transcriptional Analysis of Controlling Enzymes in Bovine Ovarian Follicle. Int J Mol Sci 2018 Oct; 19(10): .

Mailfert S, Touvier J, Benyoussef L, Fabre R, Rabaoui A, Blache MC, Hamon Y, Brustlein S, Monneret S..., A Theoretical High-Density Nanoscopy Study Leads to the Design of UNLOC, a Parameter-free Algorithm., Biophys J 2018 Aug; 115(3): 565-576.

Treffier A, Musnier A, Landomiel F, Bourquard T, Boulo T, Ayoub MA, León K, Bruneau G, Chevalier M,..., G protein-dependent signaling triggers a β-arrestin-scaffolded p70S6K/rpS6 module that controls 5'TOP mRNA translation. FASEB J 2018 Mar; 32(3): 1154-1169.

Bertin A, Beraud A, Lansade L, Blache MC, Diot A, Mulot B, Arnould C, Facial display and blushing: Means of visual communication in blue-and-yellow macaws (Ara Ararauna)? PLoS One 2018; 13(8): e0201762.

Lamy J, Corbin E, Blache MC, Garanina AS, Uzbekov R, Mermillod P, Saint-Dizier M, Steroid hormones regulate sperm-oviduct interactions in the bovine. Breeding 2017 Oct; 154(4): 497-508.

Mauroy C, Castagnos P, Orio J, Blache MC, Rico-Lattes I, Teissié J, Rols MP, Blanzat M, Versatile cellular uptake mediated by catanionic vesicles: simultaneous spontaneous membrane fusion and endocytosis. Mol Pharm 2015 Jan; 12(1): 103-10.

Rochette PA, Laliberté M, Bertrand-Grenier A, Houle MA, Blache MC, Légaré F, Pearson A, Visualization of mouse neuronal ganglia infected by Herpes Simplex Virus 1 (HSV-1) using multimodal non-linear optical microscopy. PLoS One 2014; 9(8): e105103.

Mauroy C, Portet T, Winterhalder M, Bellard E, Blache MC, Teissié J, Zumbusch A, Rols MP, Giant lipid vesicles under electric field pulses assessed by non-invasive imaging. Bioelectrochemistry 2012 Oct; 87(): 253-9.

Mauroy C, Castagnos P, Blache MC, Teissié J, Rico-Lattes I, Rols MP, Blanzat M, Interaction between GUVs and catanionic nanocontainers: new insight into spontaneous membrane fusion. Chem Commun (Camb) 2012 Jul; 48(53): 6648-50.