Julie TOMAS – CIML

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About

A graduate of Polytech Marseille (2009) as a Biological Engineer and a PhD in Microbiology (2013), I began my career at DSM Nutritional Products, where I worked on third-generation probiotics. I then completed a thesis within Philippe Langella's team (2010-2013, INRAE, MICALIS), focusing on the role of primary colonizing bacteria in the maturation of the colonic epithelium. My postdoctoral career took me to the Institut Pasteur (2013-2016, Philippe Sansonetti's team, Paris), where I integrated the dimension of malnutrition into the study of the intestinal microbiota, then to the Marseille Luminy Immunology Center (2016-2023, Jean-Pierre Gorvel's team), where I acquired expertise in mucosal immunity. Recruited by the CNRS in 2019 as a research fellow, I currently develop projects at the interface between nutrition, intestinal microbiota, and enteropathies. My work focuses in particular on the early effects of malnutrition on physiology, metabolism, microbiota, and immunity. I also explore the role of sexual dimorphism in the response to vaccine and probiotic interventions.

Projects

Intracellular Carriers Against Resistant microOrganisms (ICARO)

Project: ICARO Current acellular vaccines are mostly effective against extracellular pathogens, but fail to induce a response […]

Hugues LELOUARD

Cyrille MIONNET

Publications

Bravo-Núñez Á, Berthomé A, Sabran C, Vairo D, Martin JC, Alvarado-Ramos K, Chassaing B, Tomas J,..., Substitution of polysorbates by plant-based emulsifiers: impact on vitamin D bioavailability and gut health in mice. Commun Biol 2025 Jun;8(1):896.

Arroyo Portilla C, Fenouil R, Wagner C, Luciani C, Lagier M, Da Silva C, Hidalgo-Villeda F, Spinelli..., Peyer's patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles. Mucosal Immunol 2023 Aug; 16(4): 527-547.

Hidalgo-Villeda F, Million M, Defoort C, Vannier T, Svilar L, Lagier M, Wagner C, Arroyo-Portilla C,..., Prolonged dysbiosis and altered immunity under nutritional intervention in a physiological mouse model of severe acute malnutrition. iScience 2023 Jun; 26(6): 106910.

F. Hidalgo-Villeda, M. Million, C. Defoort, F. Sicard, M. Lagier, C. Wagner, C. Arroyo-Portilla, L. ..., A novel mouse model of severe acute malnutrition in children reveals defective Peyer's patch immunity and altered microbiota and metabolomic profile, <i>French-Speaking Nutrition Days 2021</i>, Nov 2021, Lille, France. pp.S6-S7, <a target="_blank" href="https://dx.doi.org/10.1016/j.nupar.2021.12.012">⟨10.1016/j.nupar.2021.12.012⟩</a>.

Julie Tomas, Yoon Koo, Dimitri Popoff, Vilma Arce-Gorvel, Sean Hanniffy, Jean-Pierre Gorvel, Cyrille..., PTX Instructs the Development of Lung-Resident Memory T Cells in Bordetella pertussis Infected Mice, <i>Toxins</i>, 2021, 13 (9), pp.632. <a target="_blank" href="https://dx.doi.org/10.3390/toxins13090632">⟨10.3390/toxins13090632⟩</a>.

Arroyo Portilla C, Tomas J, Gorvel JP, Lelouard H, From Species to Regional and Local Specialization of Intestinal Macrophages. Front Cell Dev Biol 2020; 8(): 624213.

Million M, Tomas J, Wagner C, Lelouard H, Raoult D, Gorvel JP, New insights into gut microbiota and mucosal immunity of the small intestine, Human Microbiome Journal 2018; 7-8:23-32.

João Ricardo Araújo, Julie Tomas, Christiane Brenner, Philippe Sansonetti, Impact of high-fat diet on the intestinal microbiota and small intestinal physiology before and after the onset of obesity, <i>Biochemistry</i>, 2017, 141, pp.97-106. <a target="_blank" href="https://dx.doi.org/10.1016/j.biochi.2017.05.019">⟨10.1016/j.biochi.2017.05.019⟩</a>.

Julie Tomas, Céline Mulet, Azadeh Saffarian, Jean-Baptiste Cavin, Robert Ducroc, Béatrice Regnault..., High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine, <i>Proceedings of the National Academy of Sciences of the United States of America</i>, 2016, 113 (40), pp.E5934-E5943. <a target="_blank" href="https://dx.doi.org/10.1073/pnas.1612559113">⟨10.1073/pnas.1612559113⟩</a>.

Julie Tomas, Julie Reygner, Camille Mayeur, Robert Ducroc, Stephan Bouet, Chantal Bridonneau, Jean-B..., Early colonizing [i]Escherichia coli[/i] elicits remodeling of rat colonic epithelium shifting toward a new homeostatic state, <i>The International Society of Microbiological Ecology Journal</i>, 2015, 9 (1), pp.46-58. <a target="_blank" href="https://dx.doi.org/10.1038/ismej.2014.111">⟨10.1038/ismej.2014.111⟩</a>.

Julie Tomas, Interactions of the Intestinal Microbiota with Mucosal Epithelial Cells, <i>Intestinal Microbiota in Health and Disease</i>, CRC Press, pp.49-68, 2014, <a target="_blank" href="https://dx.doi.org/10.1201/b16442-4">⟨10.1201/b16442-4⟩</a>.

Julie Tomas, Laura Wrzosek, Nassim Bouznad, Stephan Bouet, Camille Mayeur, Marie-Louise Noordine, Ed..., Primocolonization is associated with colonic epithelial maturation during conventionalization, <i>FASEB Journal</i>, 2013, 27 (2), pp.645-655. <a target="_blank" href="https://dx.doi.org/10.1096/fj.12-216861">⟨10.1096/fj.12-216861⟩</a>.

Williams Turpin, Christele Humblot, Marie-Louise Noordine, Laura Wrzosek, Julie Tomas, Camille Mayeu..., Behavior of Lactobacilli isolated from fermented slurry ([i]ben-saalga[/i]) in gnotobiotic rats, <i>PLoS ONE</i>, 2013, 8 (4), <a target="_blank" href="https://dx.doi.org/10.1371/journal.pone.0057711">⟨10.1371/journal.pone.0057711⟩</a>.