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Hussein Hamade is a researcher in immunology and gastroenterology, specializing in inflammatory bowel disease (IBD) and intestinal fibrosis. After completing a PhD at the University of Strasbourg on the links between inflammation and colorectal cancer, he continued his scientific career at Cedars-Sinai Medical Center in Los Angeles, where he studied the role of immune cells, microbiota, and intestinal epithelium in homeostasis and metabolic pathologies. His work contributes to a better understanding of the etiology of IBD and its complications. He is currently conducting his research at the Marseille-Luminy Immunology Center (CIML), where he analyzes the interactions between fibroblasts, immune cells, and chronic inflammation to elucidate the mechanisms of intestinal fibrosis and pave the way for new therapeutic approaches.

Publications

2024
Hamade H, Tsuda M, Oshima N, Stamps DT, Wong MH, Stamps JT, Thomas LS, Salumbides BC, Jin C, Nunnele..., Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8+ T cells. Front Immunol 2024; 15(): 1465175.
2023
Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Menge..., Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. Gut 2023 Nov; 72(11): 2068-2080.
2023
Shimodaira Y, More SK, Hamade H, Blackwood AY, Abraham JP, Thomas LS, Miller JH, Stamps DT, Castanon..., DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury. Cell Mol Gastroenterol Hepatol 2023; 16(1): 83-105.
2022
Oh S, Li K, Prince A, Wheeler ML, Hamade H, Nguyen C, Michelsen KS, Underhill DM, Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 Th9 cell differentiation. Cell Rep 2022 Mar; 38(13): 110567.
2022
Hamade H, Stamps JT, Stamps DT, More SK, Thomas LS, Blackwood AY, Lahcene NL, Castanon SL, Salumbide..., BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis. Front Immunol 2022; 13():841065.
2019
Tsuda M, Hamade H, Thomas LS, Salumbides BC, Potdar AA, Wong MH, Nunnelee JS, Stamps JT, Neutzsky-Wu..., A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies. Mucosal Immunol 2019 May; 12(3): 644-655.
2017
De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, Méchine-Neuville A, Siebert S..., Hemidesmosome integrity protects the colon against colitis and colorectal cancer. Gut 2017 Oct; 66(10): 1748-1760.