About
I obtained a Master's degree in Physics of Complex Systems from Pierre and Marie Curie University Paris 6 (now Sorbonne University). During my PhD at the Institut Pasteur, I studied bacterial motility in chemoattractant gradients under the supervision of Massimo Vergassola. I then began studying T cell biology during my postdoctoral fellowship with Grégoire Altan-Bonnet at the Sloan Kettering Institute. Since joining the CIML, I have been studying the molecular mechanisms at work during T cell activation. At the CIML, I was first part of the team led by Bernard and Marie Malissen before joining Romain Roncagalli's team.
T cell activation follows the recognition of an antigen by their TCR (T cell receptor). The interaction between the antigen and the TCR gives rise to a complex signaling cascade involving numerous molecular events, such as post-translational modifications or protein interactions. This results in the activation of T cells, which proliferate and acquire effector functions allowing the elimination of the antigen. I am interested in the exhaustive identification of the different events involved in T cell activation. To do this, I often use mass spectrometry-based approaches. One of my goals is also to determine the functions of these different events in the T cell activation process in the hope of being able to control some of their harmful or beneficial properties in antitumor responses or during autoimmune diseases. I am also particularly interested in how T lymphocytes are able to respond to a small amount of agonistic antigens while remaining insensitive to a large amount of lower affinity antigens. I am thus seeking to identify the molecular events involved in this process of antigenic discrimination, the deregulation of which can be pathological.
Publications
Funding
