About
Dr. Guillaume Hoeffel received his PhD in Immunology in 2007 in the laboratory of Anne Hosmalin at the University Paris Descartes, where he studied antigen presentation by human dendritic cell subsets in the context of HIV infection and vaccination.
After a short passage in the lab of Dr Lynda Stuart in 2008 at the Mass. General Hospital, Boston MA, USA as a postdoctoral fellow, he joined the lab of Dr Florent Ginhoux in Singapore to study the ontogeny of tissue-resident macrophages. He described the different embryonic hematopoietic waves and the cellular events that give rise to microglia in the brain and all resident macrophages which seed every peripheral tissue before birth.
In 2016, he went back to France, joining the emerging team of Dr Sophie Ugolini to study the neural regulation of immunity and in particular how sensory neurons (SN) regulate tissue repair function of dermal macrophages. He discovered how the neurokine TAFA4, produced by a subset of SN called C-LTMR promote anti-fibrotic functions of Tim4+ dermal macrophages in a sunburn-like model of skin lesion.
As a Researcher INSERM since 2017, he continues his investigations regarding the neuroimmune pathways involved in tissue regeneration, including the role of the stress pathway driven by the Hypothalamo-Pituitary-Adrenal (HPA) axis, and more recently in the context of Obesity and Type 2 Diabetes funded by the ANR “T2DRGMacPain”.
Projects
Project: T2DRGMacPain Obesity is a major factor in metabolic disorders such as type 2 diabetes. Dysfunction of […]
We have demonstrated that the neurokine TAFA4, produced by sensory neurons in the skin, can promote tissue repair […]
Les macrophages résidents des tissus jouent un rôle fondamental dans l’homéostasie tissulaire et sa régénération après lésion. Dans un modèle […]
Beyond the pain perception processes that are induced in the event of injury or infection of the […]