Franck GALLAND – CIML

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Dorian BOURGEON

About

Franck Galland joined the team in 2024 Innate Immunity at Mucosal Sites (Dr. A. Broggi, CIML), where he studies the metabolic role of intestinal epithelial cells in chronic inflammatory bowel diseases (IBD) as well as the therapeutic potential of targeting CoA metabolism.

In 1996, alongside Prof. Philippe Naquet at CIML, he co-discovered the Vanin family of enzymes and subsequently demonstrated the key role of pantetheinase Vnn1 in protecting the intestinal mucosa, stimulating mucus production and strengthening resistance to colitis via regulation of vitamin B5/CoA metabolism.

A professor at Aix-Marseille University (AMU), he has supervised seven doctoral theses. He was the project leader for the creation of the Master of Immunology in 2018, which he still directs today. This Master obtained the label of excellence in 2024 amideX PLUS as part of the initiative TIGER–France 2030.

Publications

Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenou..., Type III interferons induce pyroptosis in gut epithelial cells and odd mucosal repair. Cell 2024 Dec; 187(26): 7533-7550.e23.

Miallot R, Millet V, Roger A, Fenouil R, Tardivel C, Martin JC, Tranchida F, Shintu L, Berchard P, S..., Correction: The coenzyme A precursor pantethine enhances antitumor immunity in sarcoma., Life Sci Alliance 2024 Feb; 7(2): .

Richard Miallot, Virginie Millet, Anais Roger, Romain Fenouil, Catherine Tardivel, Jean-Charles Mart..., The coenzyme A precursor pantethine enhances antitumor immunity in sarcoma, <i>Life Science Alliance</i>, 2023, 6 (12), pp.e202302200. <a target="_blank" href="https://dx.doi.org/10.26508/lsa.202302200">⟨10.26508/lsa.202302200⟩</a>.

Richard Miallot, Virginie Millet, Franck Galland, Philippe Naquet, The vitamin B5/coenzyme A axis: A target for immunomodulation?, <i>European Journal of Immunology</i>, 2023, 53 (10), <a target="_blank" href="https://dx.doi.org/10.1002/eji.202350435">⟨10.1002/eji.202350435⟩</a>.

Millet V, Gensollen T, Maltese M, Serrero M, Lesavre N, Bourges C, Pitaval C, Cadra S, Chasson L, Vu..., Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis. Gut 2023 Jun; 72(6): 1115-1128.

Miallot R, Millet V, Groult Y, Modelska A, Crescence L, Roulland S, Henri S, Malissen B, Brouilly N,..., An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity. Life Sci Alliance 2023 Jun; 6(6): .

Ait-Belkacem I, Cartagena García C, Millet-Wallisky E, Izquierdo N, Loosveld M, Arnoux I, Morange P..., SARS-CoV-2 spike protein induces a differential monocyte activation that may contribute to age bias in COVID-19 severity., Sci Rep 2022 Dec; 12(1): 20824.

Allardet-Servent J, Ait Belkacem I, Miloud T, Benarous L, Galland F, Halfon P, Mège JL, Penaranda G..., The Association of Low CD4 Expression on Monocytes and Low CD8+ T-Cell Count at Hospital Admission Predicts the Need for Mechanical Ventilation in Patients With COVID-19 Pneumonia: A Prospective Monocentric Cohort Study., Crit Care Explor 2022 Dec; 4(12): e0810.

Ines Ait Belkacem, Noushine Mossadegh‐keller, Penelope Bourgoin, Isabelle Arnoux, Marie Loosveld, ..., Cell Analysis from Dried Blood Spots: New Opportunities in Immunology, Hematology, and Infectious Diseases, <i>Advanced Science</i>, 2021, 8 (18), pp.2100323. <a target="_blank" href="https://dx.doi.org/10.1002/advs.202100323">⟨10.1002/advs.202100323⟩</a>.

Ines Ait Belkacem, Pénélope Bourgoin, Jean Busnel, Franck Galland, Fabrice Malergue, One-step White Blood Cell Extracellular Staining Method for Flow Cytometry, <i>Bio-protocol </i>, 2021, 11 (16), <a target="_blank" href="https://dx.doi.org/10.21769/BioProtoc.4135">⟨10.21769/BioProtoc.4135⟩</a>.

Richard Miallot, Franck Galland, Virginie Millet, Jean-Yves Blay, Philippe Naquet, Metabolic landscapes in sarcomas, <i>Journal of Hematology and Oncology</i>, 2021, 14 (1), <a target="_blank" href="https://dx.doi.org/10.1186/s13045-021-01125-y">⟨10.1186/s13045-021-01125-y⟩</a>.

Giessner C, Millet V, Mostert KJ, Gensollen T, Vu Manh TP, Garibal M, Dieme B, Attaf-Bouabdallah N, ..., Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity. Life Sci Alliance 2018 Aug; 1(4): e201800073.

Kavian N, Mehlal S, Marut W, Servettaz A, Giessner C, Bourges C, Nicco C, Chéreau C, Lemaréchal H,..., Imbalance of the Vanin-1 Pathway in Systemic Sclerosis., J Immunol 2016 Oct; 197(8): 3326-3335.

Niloufar Kavian, Souad Mehlal, Wioleta Marut, Amelie Servettaz, Caroline Giessner, Christophe Bourge..., Imbalance of the Vanin-1 Pathway in Systemic Sclerosis, <i>Journal of Immunology</i>, 2016, 197 (8), pp.3326-3335. <a target="_blank" href="https://dx.doi.org/10.4049/jimmunol.1502511">⟨10.4049/jimmunol.1502511⟩</a>.

Ferreira DW, Goedken MJ, Rommelaere S, Chasson L, Galland F, Naquet P, Manautou JE, Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses. Biochim Biophys Acta 2016 Apr; 1862(4): 662-669.

Philippe Naquet, Caroline Giessner, Franck Galland, Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity, <i>Current Opinion in Immunology</i>, 2016, 38, pp.30-38. <a target="_blank" href="https://dx.doi.org/10.1016/j.coi.2015.10.005">⟨10.1016/j.coi.2015.10.005⟩</a>.

Rommelaere S, Millet V, Rihet P, Atwell S, Helfer E, Chasson L, Beaumont C, Chimini G, Sambo Mdo R, ..., Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria. Am J Pathol 2015 Nov; 185(11): 3039-52.

Niloufar Kavian, Wioleta Marut, Amélie Servettaz, Carole Nicco, Christiane Chéreau, Hervé Lemaré..., Pantethine Prevents Murine Systemic Sclerosis Through the Inhibition of Microparticle Shedding, <i>Arthritis & Rheumatology</i>, 2015, 67 (7), pp.1881-1890. <a target="_blank" href="https://dx.doi.org/10.1002/art.39121">⟨10.1002/art.39121⟩</a>.

Naquet P, Pitari G, Duprè S, Galland F, Role of the Vnn1 pantetheinase in tissue tolerance to stress. Biochem Soc Trans 2014 Aug; 42(4): 1094-100.

van Diepen JA, Jansen PA, Ballak DB, Hijmans A, Hooiveld GJ, Rommelaere S, Galland F, Naquet P, Rutj..., PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism. J Hepatol 2014 Aug; 61(2): 366-72.

Rommelaere S, Millet V, Vu Manh TP, Gensollen T, Andreoletti P, Cherkaoui-Malki M, Bourges C, Escali..., Sox17 regulates liver lipid and metabolism adaptation to fasting. PLoS One 2014; 9(8): e104925.

Elsa Frangin, MP Koenig, Henri-Georges Naton, R. Prouteau, S. Galland, Franck Decanter, Julian Wie..., A succession of medieval rural dwellings (6th-12th century) in the commune of Les Trois Domaines (Lorraine, Meuse), Archaeological Review of the East , 2014, 63, pp.337-412.

Rommelaere S, Millet V, Gensollen T, Bourges C, Eeckhoute J, Hennuyer N, Baugé E, Chasson L, Caccia..., PPARalpha regulates the production of serum Vanin-1 by liver. FEBS Lett 2013 Nov; 587(22): 3742-8.

Thomas Gensollen, Christophe Bourges, Pascal Rihet, Agathe Rostan, Virginie Millet, Tetsuro Noguchi,..., Functional Polymorphisms in the Regulatory Regions of the VNN1 Gene Are Associated with Susceptibility to Inflammatory Bowel Diseases, <i>Inflammatory Bowel Diseases</i>, 2013, 19 (11), pp.2315-2325. <a target="_blank" href="https://dx.doi.org/10.1097/MIB.0b013e3182a32b03">⟨10.1097/MIB.0b013e3182a32b03⟩</a>.

Martial Mermillod, Damien Devaux, Philippe Derost, Isabelle Rieu, Patrick Chambres, Catherine Auxiet..., Rapid Presentation of Emotional Expressions Reveals New Emotional Impairments in Tourette's Syndrome. <i>Frontiers in Human Neuroscience</i>, 2013, 7, pp.149. <a target="_blank" href="https://dx.doi.org/10.3389/fnhum.2013.00149">⟨10.3389/fnhum.2013.00149⟩</a>.

Isabelle Jalenques, Fabienne Galland, Laurent Malet, Dominique Morand, Guillaume Legrand, Candy Aucl..., Quality of life in adults with Gilles de la Tourette Syndrome, <i>BMC Psychiatry</i>, 2012, 12 (1), <a target="_blank" href="https://dx.doi.org/10.1186/1471-244X-12-109">⟨10.1186/1471-244X-12-109⟩</a>.

Benjamin Betgen, Marie-Annick Galland, E. Piot, Franck Simon, Implementation and non-intrusive characterization of a hybrid active-passive liner with grazing flow, <i>Applied Acoustics</i>, 2012, 73, pp.624-628. <a target="_blank" href="https://dx.doi.org/10.1016/j.apacoust.2012.01.008">⟨10.1016/j.apacoust.2012.01.008⟩</a>.

Annabelle Cesaro, Patrick Brest, Véronique Hofman, Xavier Hébuterne, Scott Wildman, Bernard Ferrua..., Amplification loop of the inflammatory process is induced by P2X7R activation in intestinal epithelial cells in response to neutrophil transepithelial migration. <i>AJP - Gastrointestinal and Liver Physiology</i>, 2010, 299 (1), pp.G32-42. <a target="_blank" href="https://dx.doi.org/10.1152/ajpgi.00282.2009">⟨10.1152/ajpgi.00282.2009⟩</a>.

Arnaud Lefebvre, Franck Thiériot, Agnès Charignon, Sophie Galland-Crety, An atypical funeral practice for the Late Bronze Age in Lorraine (France), Transitions, ruptures and continuities in prehistory. 27th Prehistoric Congress of France , May 2010, Bordeaux-Les Eyzies, France.

Pouyet L, Roisin-Bouffay C, Clément A, Millet V, Garcia S, Chasson L, Issaly N, Rostan A, Hofman P,..., Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model. Inflamm Bowel Dis 2010 Jan; 16(1): 96-104.

Cesaro A, Abakar-Mahamat A, Brest P, Lassalle S, Selva E, Filippi J, Hébuterne X, Hugot JP, Doglio ..., Differential expression and regulation of ADAM17 and TIMP3 in acute inflamed intestinal epithelia. Am J Physiol Gastrointest Liver Physiol 2009 Jun; 296(6): G1332-43.

Luana Di Leandro, Bruno Maras, M Eugenia Schininà, Silvestro Dupré, Ilias Koutris, Florent M Marti..., Cystamine restores GSTA3 levels in Vanin-1 null mice. <i>Free Radical Biology and Medicine</i>, 2008, 44 (6), pp.1088-96. <a target="_blank" href="https://dx.doi.org/10.1016/j.freeradbiomed.2007.12.015">⟨10.1016/j.freeradbiomed.2007.12.015⟩</a>.

Isabelle Jalenques, Fabienne Galland, G. Legrand, Philippe Derost, Martial Mermillod, Catherine Auxi..., Clinic for Gilles de la Tourette syndrome in adults. Medical-Psychological Annals, Psychiatric Review , 2008, 166 (4), pp.319-323.

Fabienne Galland, Philippe Derost, G. Legrand, F. Noton-Durand, Martial Mermillod, Catherine Auxiett..., Psychopathological manifestations in Tourette's disease. Medical-Psychological Annals, Psychiatric Review , 2008, 166 (4), pp.324-326.

Martial Mermillod, Catherine Auxiette, Patrick Chambres, Laetitia Silvert, Fabienne Galland, Isabell..., Different spatial frequency channels for different emotional facial expressions: behavioral and connectionist data. Cognition, Emotion & Motivation. , Oct 2007, Hammamet, Tunisia.

Morgan Desort, Anne-Marie Lagrange, Franck Galland, Stephane Udry, Michel Mayor, Search for exoplanets with the radial-velocity technique: quantitative diagnostics of stellar activity, 2007.

Soraya Meghari, Carole Berruyer, Hubert Lepidi, Franck Galland, Philippe Naquet, Jean-Louis Mege, Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection. <i>European Journal of Immunology</i>, 2007, 37 (1), pp.24-32. <a target="_blank" href="https://dx.doi.org/10.1002/eji.200636054">⟨10.1002/eji.200636054⟩</a>.

Meghari S, Berruyer C, Lepidi H, Galland F, Naquet P, Mege JL, Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection. Eur J Immunol 2007 Jan;37(1):24-32.

Carole Berruyer, Laurent Pouyet, Virginie Millet, Florent M Martin, Aude Legoffic, Alexandra Canonic..., Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. <i>Journal of Experimental Medicine</i>, 2006, 203 (13), pp.2817-27. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20061640">⟨10.1084/jem.20061640⟩</a>.

Franck Galland, Planets and brown dwarfs around hot stars. Astrophysics [astro-ph]. Joseph Fourier University - Grenoble I, 2006. French. <a target="_blank" href="https://www.theses.fr/">⟨NNT : ⟩</a>.

Carole Berruyer, Laurent Pouyet, Virginie Millet, M. Martin Florent, Aude Legoffic, Alexandra Canoni..., Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity, <i>Journal of Experimental Medicine</i>, 2006, 203 (13), pp.2817-2827. <a target="_blank" href="https://dx.doi.org/10.1084/jem/20061640">⟨10.1084/jem/20061640⟩</a>.

Martin F, Penet MF, Malergue F, Lepidi H, Dessein A, Galland F, de Reggi M, Naquet P, Gharib B, Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores. J Clin Invest 2004 Feb; 113(4): 591-7.