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Bilal El Waly is a researcher specializing in the mechanisms of central nervous system (CNS) repair, with particular expertise in neuroinflammation and glial cell biology. His multidisciplinary approach combines genetic models and advanced intravital imaging techniques to dissect in real-time the complex interactions between the nervous and immune systems. His current research aims to understand how peripheral sensory neurons regulate neuroinflammation in order to identify new therapeutic targets for demyelinating and neurodegenerative diseases.

Projects

Project
2025
Regulation of inflammation by the neurokine TAFA4

We have demonstrated that the neurokine TAFA4, produced by sensory neurons in the skin, can promote tissue repair […]

Sophie UGOLINI

Publications

2025
Culley G, Henriques A, Hardy D, Wojcinski A, Chabert A, El Waly B, Poindron P, Callizot N, Amyloid-beta peptide toxicity in the aged brain is a one-way journey into Alzheimer’s disease., Front Aging Neurosci 2025 ; 17(): 1569181.
2024
Chahla C, Rima M, Mouawad C, Roufayel R, Kovacic H, El Obeid D, Sabatier JM, Luis J, Fajloun Z, El-W..., Effect of Apis mellifera syriaca Bee Venom on Glioblastoma Cancer: In Vitro and In Vivo Studies., Molecules 2024 Aug; 29(16): .
2023
Escarrat V, Perez-Sanchez J, El-Waly B, Collazos-Castro JE, Debarbieux F, Composite Fibrin and Carbon Microfibre Implant to Modulate Postraumatic Inflammation after Spinal Cord Injury., Cells 2023 Mar; 12(6): .
2023
Buttigieg E, Scheller A, El Waly B, Kirchhoff F, Debarbieux F, Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis., Neurotherapeutics 2023 Jan; 20(1): 22-38.
2022
El Waly B, Bertet C, Paris M, Falque M, Milpied P, Magalon K, Cayre M, Durbec P, Neuroblasts contribute to oligodendrocytes generation upon demyelination in the adult mouse brain. iScience 2022 Oct; 25(10): 105102.
2022
Henriques A, Rouvière L, Giorla E, Farrugia C, El Waly B, Poindron P, Callizot N, Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo Evidence., Int J Mol Sci 2022 Aug; 23(17): .
2021
El Waly B, Escarrat V, Perez-Sanchez J, Kaur J, Pelletier F, Collazos-Castro JE, Debarbieux F, Intravital Assessment of Cells Responses to Conducting Polymer-Coated Carbon Microfibres for Bridging Spinal Cord Injury., Cells 2021 Jan; 10(1): .
2020
El Waly B, Mignon-Ravix C, Cacciagli P, Buhler E, Ben Zeev B, Villard L, Molecular characterization of a 1p36 chromosomal duplication and in utero interference define ENO1 as a candidate gene for polymicrogyria., Eur J Hum Genet 2020 Dec; 28(12): 1703-1713.
2020
Matthias Hofer, Siddarth Shivkumar, Bilal El Waly, Sophie Brasselet, Coherent Anti-Stokes Raman Scattering Through Thick Biological Tissues by Single-Wavefront Shaping, <i>Physical Review Applied</i>, 2020, 14 (2), <a target="_blank" href="https://dx.doi.org/10.1103/PhysRevApplied.14.024019">⟨10.1103/PhysRevApplied.14.024019⟩</a>.
2020
Macchi M, Magalon K, Zimmer C, Peeva E, El Waly B, Brousse B, Jaekel S, Grobe K, Kiefer F, Williams ..., Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production., Elife 2020 Jun; 9(): .
2020
El Waly B, Buttigieg E, Karakus C, Brustlein S, Debarbieux F, Longitudinal Intravital Microscopy Reveals Axon Degeneration Concomitant With Inflammatory Cell Infiltration in an LPC Model of Demyelination., Front Cell Neurosci 2020 ; 14(): 165.
2018
Pascale Durbec, Myriam Cayre, Bilal El Waly, Commentary: “Promoting Myelin Repair through In vivo Neuroblast Reprogramming, <i>Journal of Neurology & Neuromedicine</i>, 2018, 3 (4), pp.15-17. <a target="_blank" href="https://dx.doi.org/10.29245/2572.942X/2018/4.1196">⟨10.29245/2572.942X/2018/4.1196⟩</a>.
2018
El Waly B, Cayre M, Durbec P, Promoting Myelin Repair through In Vivo Neuroblast Reprogramming., Stem Cell Reports 2018 May; 10(5): 1492-1504.
2016
Magalon K, Le Grand M, El Waly B, Moulis M, Pruss R, Bordet T, Cayre M, Belenguer P, Carré M, Durbe..., Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules., Neuropharmacology 2016 Dec; 111(): 293-303.
2015
El Waly B, Buhler E, Haddad MR, Villard L, Nhej1 Deficiency Causes Abnormal Development of the Cerebral Cortex., Mol Neurobiol 2015 Aug; 52(1): 771-82.
2014
El Waly B, Macchi M, Cayre M, Durbec P, Oligodendrogenesis in the normal and pathological central nervous system., Front Neurosci 2014 ; 8(): 145.
2010
Cacciagli P, Haddad MR, Mignon-Ravix C, El-Waly B, Moncla A, Missirian C, Chabrol B, Villard L, Disruption of the ATP8A2 gene in a patient with a t(10;13) de novo balanced translocation and a severe neurological phenotype., Eur J Hum Genet 2010 Dec; 18(12): 1360-3.
2010
Mignon-Ravix C, Cacciagli P, El-Waly B, Moncla A, Milh M, Girard N, Chabrol B, Philip N, Villard L, Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia., J Med Genet 2010 Feb; 47(2): 132-6.