About
Director of the Cancéropôle PACA
Member of the Henry Kunkel Society
Member of the American Society of Haematology
Projects
Project
2025
CPC_profile: Characterization and Targeting of Cancer Precursor Cells (CPC) at the origin of relapses in B-cell lymphomas
The progression of follicular lymphoma is marked by iterative cycles of remission and relapse, the latter usually resulting from the […]
Sandrine ROULLAND
Project
2025
LYMPHOMATLAS: an atlas of B-cell lymphomas at the single-cell level
Project: LYMPHOMATLAS Single-cell multi-omic studies in B-lymphomas have highlighted a […]
Sandrine ROULLAND
Pierre MILPIED
Project
2025
Validation, adaptation and development in clinical routine of a single-cell biomarker stratifying high-risk FL patients
Patients with follicular lymphoma (FL) present a very high biological heterogeneity, which strongly impacts the response to current therapies. […]
Sandrine ROULLAND
Publications
2024
Follicular lymphoma research: an open dialogue for a collaborative roadmap,
<i>Histopathology</i>, 2024, 86 (1), pp.79-93. <a target="_blank" href="https://dx.doi.org/10.1111/his.15344">⟨10.1111/his.15344⟩</a>.
2023
A Single Cell Atlas of Diffuse Large B Cell Lymphomas Reveals Distinct Cellular States Predictive of Outcomes.
<i>65th American Society of Hematology (ASH) Annual Meeting and Exhibition</i>, Dec 2023, San Diego, CA, United States. pp.848 - 848, <a target="_blank" href="https://dx.doi.org/10.1182/blood-2023-173929">⟨10.1182/blood-2023-173929⟩</a>.
2023
Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720-1748.,
Leukemia 2023 Sep; 37(9): 1944-1951.
2023
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors,
<i>Cancer Discovery</i>, 2023, 13 (6), pp.1310-1323. <a target="_blank" href="https://dx.doi.org/10.1158/2159-8290.CD-23-0111">⟨10.1158/2159-8290.CD-23-0111⟩</a>.
2023
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells.
Cell Stem Cell 2023 Jan; 30(1): 112.
2023
Single-Cell Longitudinal Characterization of FL Heterogeneity and Residual Disease in the Bone Marrow from Low-Tumor Burden FL Enrolled in the Flirt Clinical Trial,
<i>65th ASH Annual Meeting</i>, Dec 2023, San Diego, United States. pp.852, <a target="_blank" href="https://dx.doi.org/10.1182/blood-2023-186070">⟨10.1182/blood-2023-186070⟩</a>.
2023
TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2,
<i>Molecular Cancer</i>, 2023, 22 (1), pp.108. <a target="_blank" href="https://dx.doi.org/10.1186/s12943-023-01794-y">⟨10.1186/s12943-023-01794-y⟩</a>.
2022
Genomic profiling for clinical decision making in lymphoid neoplasms.,
Blood 2022 Nov; 140(21): 2193-2227.
2022
The EHA Research Roadmap: Malignant Lymphoid Diseases,
<i>HemaSphere</i>, 2022, 6, <a target="_blank" href="https://dx.doi.org/10.1097/hs9.0000000000000726">⟨10.1097/hs9.0000000000000726⟩</a>.
2021
Human B Lymphomas Reveal Their Secrets Through Genetic Mouse Models,
<i>Frontiers in Immunology</i>, 2021, 12, <a target="_blank" href="https://dx.doi.org/10.3389/fimmu.2021.683597">⟨10.3389/fimmu.2021.683597⟩</a>.
2021
MYC deficiency impairs the development of effector/memory T lymphocytes,
<i>iScience</i>, 2021, 24 (7), pp.102761. <a target="_blank" href="https://dx.doi.org/10.1016/j.isci.2021.102761">⟨10.1016/j.isci.2021.102761⟩</a>.
2021
The Premalignant Ancestor Cell of t(14;18)+ Lymphoma,
<i>HemaSphere</i>, 2021, 5 (6), pp.e579. <a target="_blank" href="https://dx.doi.org/10.1097/HS9.0000000000000579">⟨10.1097/HS9.0000000000000579⟩</a>.
2021
Follicular lymphoma dynamics.
Adv Immunol 2021; 150(): 43-103.
2020
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells.
Cell Stem Cell 2020 May; 26(5): 793.
2020
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells,
<i>Cell Stem Cell</i>, 2020, 26 (5), pp.657-674.e8. <a target="_blank" href="https://dx.doi.org/10.1016/j.stem.2020.01.017">⟨10.1016/j.stem.2020.01.017⟩</a>.
2020
CeVi: une collection unique de CELLULES VIABLES humaines cryopréservées de patients atteints de LYMPHOMES, une initiative pour accélérer l’innovation et son transfert dans le domaine du LYMPHOME.,
<i>SFH</i>, 2020, Paris, France.
2019
GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors,
<i>CELL METABOLISM</i>, 2019, 29 (6), pp.1243+. <a target="_blank" href="https://dx.doi.org/10.1016/j.cmet.2019.02.002">⟨10.1016/j.cmet.2019.02.002⟩</a>.
2018
Human germinal center transcriptional programs are de-synchronized in B cell lymphoma.
Nat Immunol 2018 Sep; 19(9): 1013-1024.
2018
Fit αβ T-Cell Receptor suppresses leukemogenesis of Pten-deficient thymocytes.
<i>Haematologica</i>, 2018, <a target="_blank" href="https://dx.doi.org/10.3324/haematol.2018.188359">⟨10.3324/haematol.2018.188359⟩</a>.
2017
Follicular lymphoma: State-of-the-art ICML workshop in Lugano 2015.,
Hematol Oncol 2017 Dec; 35(4): 397-407.
2017
Lineage switch from B acute lymphoblastic leukemia to acute monocytic leukemia with persistent t(4;11)(q21;q23) and cytogenetic evolution under CD19-targeted therapy.,
Ann Hematol 2017 Sep; 96(9): 1579-1581.
2017
Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer,
<i>Nature Reviews Microbiology</i>, 2017, 15 (2), pp.109-128. <a target="_blank" href="https://dx.doi.org/10.1038/nrmicro.2016.171">⟨10.1038/nrmicro.2016.171⟩</a>.
2016
BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice,
<i>Journal of Experimental Medicine</i>, 2016, [Epub ahead of print]. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20150983">⟨10.1084/jem.20150983⟩</a>.
2016
The European Hematology Association Roadmap for European Hematology Research: a consensus document.,
Haematologica 2016 Feb; 101(2): 115-208.
2016
B-cell non-Hodgkin lymphoma linked to Coxiella burnetii,
<i>Blood</i>, 2016, 127 (1), pp.113-121. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2015-04-639617">⟨10.1182/blood-2015-04-639617⟩</a>.
2015
Premalignant cell dynamics in indolent B-cell malignancies.
Curr Opin Hematol 2015 Jul; 22(4): 388-96.
2015
Contiguous follicular lymphoma and follicular lymphoma in situ harboring N-glycosylated sites.
Haematologica 2015 Apr; 100(4): e155-7.
2015
Contiguous follicular lymphoma and follicular lymphoma in situ harboring N-glycosylated sites,
Haematologica , 2015, 100, pp.E155-E157.
2015
[Follicular lymphoma: a history of perversion of immunological memory].,
Med Sci (Paris) 2015 Apr; 31(4): 360-2.
2015
Site- and allele-specific polycomb dysregulation in T-cell leukaemia.
Nat Commun 2015 Jan;6():6094.
2014
Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression,
<i>Journal of Clinical Investigation</i>, 2014, 124 (12), pp.5337-5351. <a target="_blank" href="https://dx.doi.org/10.1172/JCI72415">⟨10.1172/JCI72415⟩</a>.
2014
RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement,
<i>Journal of Experimental Medicine</i>, 2014, 211 (9), pp.1821--1832. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20132585">⟨10.1084/jem.20132585⟩</a>.
2014
Therapeutic targeting of c-Myc in T-cell acute lymphoblastic leukemia, T-ALL.,
Oncotarget 2014 May; 5(10): 3168-72.
2014
t(14;18) Translocation: A predictive blood biomarker for follicular lymphoma.,
J Clin Oncol 2014 May; 32(13): 1347-55.
2014
Nature and importance of follicular lymphoma precursors.,
Haematologica 2014 May; 99(5): 802-10.
2014
Early lesions of follicular lymphoma: a genetic perspective.
Haematologica 2014 Mar; 99(3): 481-8.
2014
Human t(14;18)positive germinal center B cells: a new step in follicular lymphoma pathogenesis?
<i>Blood</i>, 2014, 123 (22), pp.3462-3465. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2013-12-545954">⟨10.1182/blood-2013-12-545954⟩</a>.
2014
MYC fails to efficiently shape malignant transformation in T-cell acute lymphoblastic leukemia.,
<i>Genes, Chromosomes & Cancer</i>, 2014, 53 (1), pp.52-66. <a target="_blank" href="https://dx.doi.org/10.1002/gcc.22117">⟨10.1002/gcc.22117⟩</a>.
2013
Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.,
<i>Journal of Clinical Oncology</i>, 2013, 31 (34), pp.4333-42. <a target="_blank" href="https://dx.doi.org/10.1200/JCO.2012.48.5292">⟨10.1200/JCO.2012.48.5292⟩</a>.
2013
A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency.,
Blood 2013 Nov; 122(23): 3713-22.
2012
Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL.,
Blood 2012 Oct; 120(16): 3298-309.
2012
TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression.,
Cancer Cell 2012 Apr; 21(4): 563-76.
2011
Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia,
<i>Blood</i>, 2011, 117 (24), pp.6650-6659. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2011-02-336842">⟨10.1182/blood-2011-02-336842⟩</a>.
2011
Early Steps of Follicular Lymphoma Pathogenesis,
<i>Advances in Immunology</i>, 111, Elsevier, pp.1-46, 2011, Advances in Immunology, <a target="_blank" href="https://dx.doi.org/10.1016/B978-0-12-385991-4.00001-5">⟨10.1016/B978-0-12-385991-4.00001-5⟩</a>.
2009
V(D)J targeting mistakes occur at low frequency in acute lymphoblastic leukemia.,
<i>Genes, Chromosomes & Cancer</i>, 2009, 48 (8), pp.725-36. <a target="_blank" href="https://dx.doi.org/10.1002/gcc.20677">⟨10.1002/gcc.20677⟩</a>.
2009
Agricultural pesticide exposure and the molecular connection to lymphomagenesis.
<i>Journal of Experimental Medicine</i>, 2009, 206 (7), pp.1473-83. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20082842">⟨10.1084/jem.20082842⟩</a>.
2009
[The profiling era: towards innovative approaches for tailored therapy],
Medicine/Sciences , 2009, 25 (6-7), pp.553-5.
2009
[The profiling era: towards innovative approaches for tailored therapy].,
Med Sci (Paris) 2009 ; 25(6-7): 553-5.
2008
Pathophysiological aspects of memory B-cell development.
Trends Immunol 2008 Jan; 29(1): 25-33.
2008
Pathophysiological aspects of memory B-cell development.
<i>Trends in Immunology</i>, 2008, 29 (1), pp.25-33. <a target="_blank" href="https://dx.doi.org/10.1016/j.it.2007.10.005">⟨10.1016/j.it.2007.10.005⟩</a>.
2007
Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL.,
<i>Blood</i>, 2007, 110 (1), pp.388-92. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2006-12-064816">⟨10.1182/blood-2006-12-064816⟩</a>.
2007
Screening for leukemia- and clone-specific markers at birth in children with T cell precursor ALL suggests a predominantly postnatal origin.,
<i>Blood</i>, 2007, Epub ahead of print. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2007-03-077339">⟨10.1182/blood-2007-03-077339⟩</a>.
2007
The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL) – the translocation defining a new T-ALL subtype in very young children.,
<i>Blood</i>, 2007, Epub ahead of print. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2006-12-064683">⟨10.1182/blood-2006-12-064683⟩</a>.
2007
In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.
<i>PLoS Biology</i>, 2007, 5 (3), pp.e43. <a target="_blank" href="https://dx.doi.org/10.1371/journal.pbio.0050043">⟨10.1371/journal.pbio.0050043⟩</a>.
2007
In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.
PLoS Biol 2007 Mar; 5(3): e43.
2006
Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis.
<i>Journal of Experimental Medicine</i>, 2006, 203 (11), pp.2425-31. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20061292">⟨10.1084/jem.20061292⟩</a>.
2006
Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis.
J Exp Med 2006 Oct; 203(11): 2425-31.
2006
Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures.
<i>DNA Repair</i>, 2006, 5 (9-10), pp.1246-58. <a target="_blank" href="https://dx.doi.org/10.1016/j.dnarep.2006.05.015">⟨10.1016/j.dnarep.2006.05.015⟩</a>.
2006
Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures.
DNA Repair (Amst) 2006 Sep; 5(9-10): 1246-58.
2004
Unraveling the consecutive recombination events in the human IGK locus.,
J Immunol 2004 Sep; 173(6): 3878-88.
2003
Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.,
Nat Genet 2003 Mar; 33(3): 342-4.
2002
V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.,
J Exp Med 2002 Jan; 195(1): 85-98.
1998
Sequence of the Spacer in the Recombination Signal Sequence Affects V(D)J Rearrangement Frequency and Correlates with Nonrandom Vκ Usage In Vivo,
<i>Journal of Experimental Medicine</i>, 1998, 187 (9), pp.1495-1503. <a target="_blank" href="https://dx.doi.org/10.1084/jem.187.9.1495">⟨10.1084/jem.187.9.1495⟩</a>.