Bertrand ESCALIERE – CIML

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Dorian BOURGEON

About

Career

My professional career began in 2008 after obtaining an interdisciplinary professional master's degree in "Bioinformatics, Structural Biology and Genomics" from the University of Aix-Marseille following a degree in mathematics.

My Master's internship took place at thePasteur Institute within the Resource Center for Biostatistics, Epidemiology and Pharmacoepidemiology (CeRBEP) applied to infectious diseases with the aim of modeling the resistance of pneumococcus to antibiotics based on several scenarios.

I then joined the Biometrics and Artificial Intelligence department of theINRA in Toulouse as a bioinformatics research engineer for the detection of QTL in corn.

I then joined the Marseille Luminy Immunology Center (CIML) in 2009 for a little over 2 years under the direction of Eric Vivier as a research engineer in order to set up a bioinformatics analysis service available to the various teams at the center.

Then the Machine Learning Group / Interuniversity Institute of Bioinformatics in Brussels at the Free University of Brussels in 2012 for the analysis of exome data in rare pediatric diseases.

I came back to the CIML in 2016 first in the teams of Eric Vivier and Sophie Ugolini for 6 years to study the regulatory mechanisms of innate immunity lymphocytes as well as the
role of interactions between the nervous system and the immune system in maintaining homeostasis and resolving inflammatory or infectious processes.

I am a member of the CB2M since 2022 which aims to support the center's teams in the bioinformatics component of their projects.

Expertise

Analysis of transcriptomic and genetic data:

single cell RNA seq, single nuclei RNAseq, bulk RNAseq, CrispR Cas9, Visium, Xenium

Whole Exome sequencing, Whole Genome sequencing

Statistics

Projects

Regulation of inflammation by the neurokine TAFA4

We have demonstrated that the neurokine TAFA4, produced by sensory neurons in the skin, can promote tissue repair […]

Neuroimmune regulations and viral infection

The host response to pathogens is orchestrated by the immune system and the nervous system, both present in […]

ST-omics: Structuring regional expertise in spatial transcriptomics

The ST-omics structuring action of the Cancéropôle de la Région Sud is co-coordinated by Dr Pierre Milpied (CIML), Prof Emmanuelle […]

Publications

Guia S, Fenis A, Baudesson De Chanville C, Galluso J, Medjouel H, Escaliere B, Modelska A, Vienne M,..., Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killing. J Immunother Cancer 2025 Mar; 13(3): .

Lucas Rebuffet, Janine E Melsen, Bertrand Escaliere, Daniela Basurto-Lozada, Avinash Bhandoola, Nik..., High-dimensional single-cell analysis of human natural killer cell heterogeneity, <i>Nature Immunology</i>, 2024, 25 (8), pp.1474-1488. <a target="_blank" href="https://dx.doi.org/10.1038/s41590-024-01883-0">⟨10.1038/s41590-024-01883-0⟩</a>.

Noella Lopes, Justine Galluso, Bertrand Escalière, Sabrina Carpentier, Yann Kerdiles, Eric Vivier, Tissue-specific transcriptional profiles and heterogeneity of natural killer cells and group 1 innate lymphoid cells, <i>Cell Reports Medicine</i>, 2022, 3 (11), pp.100812. <a target="_blank" href="https://dx.doi.org/10.1016/j.xcrm.2022.100812">⟨10.1016/j.xcrm.2022.100812⟩</a>.

Margaux Vienne, Marion Etiennot, Bertrand Escalière, Justine Galluso, Lionel Spinelli, Sophie Guia,..., Type 1 Innate Lymphoid Cells Limit the Antitumor Immune Response, <i>Frontiers in Immunology</i>, 2021, 12, <a target="_blank" href="https://dx.doi.org/10.3389/fimmu.2021.768989">⟨10.3389/fimmu.2021.768989⟩</a>.

Crinier A, Dumas PY, Escalière B, Piperoglou C, Gil L, Villacreces A, Vély F, Ivanovic Z, Milpied ..., Fix: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia. Cell Mol Immunol 2021 Nov; 18(11): 2578-2580.

Jingjing Qi, Adeline Crinier, Bertrand Escalière, Youqiong Ye, Zhengting Wang, Tianyu Zhang, Lucian..., Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression, <i>Cell Reports Medicine</i>, 2021, 2 (8), pp.100353. <a target="_blank" href="https://dx.doi.org/10.1016/j.xcrm.2021.100353">⟨10.1016/j.xcrm.2021.100353⟩</a>.

Adeline Crinier, Bertrand Escalière, Emilie Narni-Mancinelli, Eric Vivier, Reply to 'Comment to: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia', <i>Cellular and molecular immunology</i>, 2021, 18 (5), pp.1350-1352. <a target="_blank" href="https://dx.doi.org/10.1038/s41423-021-00678-9">⟨10.1038/s41423-021-00678-9⟩</a>.

Crinier A, Dumas PY, Escalière B, Piperoglou C, Gil L, Villacreces A, Vély F, Ivanovic Z, Milpied ..., Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia. Cell Mol Immunol 2021 May; 18(5): 1290-1304.

Lu Bai, Margaux Vienne, Ling Tang, Yann Kerdiles, Marion Etiennot, Bertrand Escalière, Justine Gall..., Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop, <i>Science</i>, 2021, 371 (6536), pp.eaba4177. <a target="_blank" href="https://dx.doi.org/10.1126/science.aba4177">⟨10.1126/science.aba4177⟩</a>.

Garvin Dodard, Angela Tata, Timothy Erick, Diego Jaime, SM Shahjahan Miah, Linda Quatrini, Bertran..., Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells, <i>Cell Reports</i>, 2020, 32 (1), pp.107855. <a target="_blank" href="https://dx.doi.org/10.1016/j.celrep.2020.107855">⟨10.1016/j.celrep.2020.107855⟩</a>.

Crinier A, Milpied P, Escalière B, Piperoglou C, Galluso J, Balsamo A, Spinelli L, Cervera-Marzal I..., High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice. Immunity 2018 Nov; 49(5): 971-986.e5.

Emilie Narni-Mancinelli, Laurent Gauthier, Myriam Baratin, Sophie Guia, Aurore Fenis, Ala-Eddine Deg..., Complement factor P is a ligand for the natural killer cell-activating receptor NKp46, <i>Science Immunology</i>, 2017, 2 (10), pp.aam9628. <a target="_blank" href="https://dx.doi.org/10.1126/sciimmunol.aam9628">⟨10.1126/sciimmunol.aam9628⟩</a>.

Rommelaere S, Millet V, Vu Manh TP, Gensollen T, Andreoletti P, Cherkaoui-Malki M, Bourges C, Escali..., Sox17 regulates liver lipid and metabolism adaptation to fasting. PLoS One 2014; 9(8): e104925.

Tomonori Kaifu, Bertrand Escalière, Louis Noël Gastinel, Eric Vivier, Myriam Baratin, B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors. <i>Cellular and Molecular Life Sciences</i>, 2011, 68 (21), pp.3531-9. <a target="_blank" href="https://dx.doi.org/10.1007/s00018-011-0802-7">⟨10.1007/s00018-011-0802-7⟩</a>.

Ana Reynders, Nadia Yessaad, Thien-Phong Vu Manh, Marc Dalod, Aurore Fenis, Camille Aubry, Georgios..., Identity, regulation and in vivo function of gut NKp46(+)RORγt(+) and NKp46(+)RORγt(-) lymphoid cells. <i>EMBO Journal</i>, 2011, 30 (14), pp.2934-47. <a target="_blank" href="https://dx.doi.org/10.1038/emboj.2011.201">⟨10.1038/emboj.2011.201⟩</a>.