About
After a master's degree in genetics, I completed a thesis in Françoise Porteu's laboratory at the Cochin Institute (Paris), dedicated to the study of the mechanisms by which HSCs preserve their genomic integrity. In particular, I highlighted the central role of thrombopoietin (TPO) in the repair of DNA damage induced by genotoxic treatments.
I then joined Michael Sieweke's lab at CIML for a postdoctoral fellowship, where I studied the involvement of HSCs in the immune response. Our work showed that inflammatory signals can induce stable epigenetic modifications in HSCs, promoting their differentiation towards the myeloid lineage and thus strengthening the body's ability to fight infections.
Since 2020, I have been a research fellow at Inserm. My projects aim to explore in more detail the mechanisms of epigenetic memory in HSCs and their long-term consequences on the function of these cells.
expertises
Cellules souches hématopoiétiques, hématopoiése, inflammation, mémoire épigénétique
Internal cross-functional missions
Membre du comité de thèse du CIML
Projects
Project: HSC-Immunobiography My goal is to understand how inflammatory stresses encountered during an individual's life […]
Project: HematoMaf Although hematopoietic stem cells (HSCs) have been used in cell therapy in humans for over 40 years, […]
Project: CureMAC This Franco-German research project, coordinated by Sandrine Sarrazin, combines the expertise of her group with that of the teams […]
Bone marrow metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02). Duration: 2023–2027 (42 months).Partners & funding amounts: Institut Curie (L. Perié), Institut […]
Publications
Funding
