Elena TOMASELLO – CIML

Search

Theme

About

Italian Senior Researcher, joined the team in 2012.
Her main research interest is the dissection of the molecular mechanisms regulating the functional heterogeneity of mouse and human plasmacytoid dendritic cells.

News

Une découverte majeure remet en question le rôle de certaines cellules immunitaires dans les infections virales respiratoires

L’équipe de Marc Dalod du CIML démontre que certaines cellules immunitaires spécialisées peuvent être néfastes plutôt que protectrices lors d’infections […]

Projects

DECrypting of the Tissue Instruction of Plasmacytoid Dendritic Cells in Homeostasis and Viral Infections (DECITIP)

Project: DECITIP Plasmacytoid dendritic cells (pDCs) excel in the production of type I and III interferons (IFN), […]

Elena TOMASELLO

Role of plasmacytoid dendritic cells in disease-associated behavior (DC) induced during viral infections or obesity (pDCComp)

Project: pDCComp Individuals infected with viruses or suffering from inflammatory diseases develop a set of behavioral disorders […]

Elena TOMASELLO

Role of interactions with dendritic cells in maintaining NK cell functions in tumor conditions

Project: PLBIO 2024 Coordinator: Thierry Walzer, CIRI, Lyon. Other participant: Nathalie Bendriss-Vermare, CRCL, Lyon. Abstract: Natural Killer cells […]

To determine how dendritic cells promote effective anti-tumor NK and CD8 T responses in mouse models of breast cancer, spontaneously or in response to adjuvant administration

Project: ACLAMADABREC Partly through their effectiveness in activating natural killer (NK) cells and CD8 T lymphocytes […]

Computational deciphering and mathematical modeling of regulatory networks controlling plasmacytoid dendritic cell biology

Project: MITI Other participants: Magali Richard, LIG, Grenoble; Lionel Spinelli, CB2M hub of CIML. Summary: This project aims to […]

Accelerating our ability to understand and combat immunopathology caused by respiratory infections due to emerging viruses: from mouse models to patients to macaques

Project: UNFIRE Other participants: Ciphe (Ana Zarubica), Hospices Civils de Lyon and CIRI (Sophie Trouillet-Assant, Thierry Walzer), CoVir team […]

Philippe PIERRE

Role of type I interferons and plasmacytoid dendritic cells in pulmonary immunopathology caused by respiratory viral infections

Project: RIPIREVI Other participants: CIPHE (Ana Zarubica and colleagues). Abstract: Type I interferons (IFN-Is) are essential for […]

Publications

Clemence Ngo, Khalissa Rahmani, Michael Valente, Nils Collinet, Gilles Bessou, Manon Fabregue, Sarah..., Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections, 2024.

Abbas A, Vu Manh TP, Valente M, Collinet N, Attaf N, Dong C, Naciri K, Chelbi R, Brelurut G, Cervera..., The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection. Nat Immunol 2020 Sep; 21(9): 983-997.

Stephanie Vargas Aguilar, Oscar Aguilar, Rhys Allan, El Ad David Amir, Veronique Angeli, Maxim N. Ar..., ImmGen at 15, <i>Nature Immunology</i>, 2020, 21 (7), pp.700-703. <a target="_blank" href="https://dx.doi.org/10.1038/s41590-020-0687-4">⟨10.1038/s41590-020-0687-4⟩</a>.

Tomasello E, Yessaad N, Gregoire E, Hudspeth K, Luci C, Mavilio D, Hardwigsen J, Vivier E, Mapping of NKp46(+) Cells in Healthy Human Lymphoid and Non-Lymphoid Tissues. Front Immunol 2012; 3(): 344.

Ana Reynders, Nadia Yessaad, Thien-Phong Vu Manh, Marc Dalod, Aurore Fenis, Camille Aubry, Georgios..., Identity, regulation and in vivo function of gut NKp46(+)RORγt(+) and NKp46(+)RORγt(-) lymphoid cells. <i>EMBO Journal</i>, 2011, 30 (14), pp.2934-47. <a target="_blank" href="https://dx.doi.org/10.1038/emboj.2011.201">⟨10.1038/emboj.2011.201⟩</a>.

Grégoire C, Chasson L, Luci C, Tomasello E, Geissmann F, Vivier E, Walzer T, The trafficking of natural killer cells. Immunol Rev 2007 Dec; 220(1): 169-82.

Chiesa S, Mingueneau M, Fuseri N, Malissen B, Raulet DH, Malissen M, Vivier E, Tomasello E, Multiplicity and plasticity of natural killer cell signaling pathways. Blood 2006 Mar; 107(6): 2364-72.

Serge Nataf, Adrienne Anginot, Carine Vuaillat, Luc Malaval, Nassima Fodil, Emmanuel Chereul, Jean-B..., Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages. American Journal of Pathology , 2005, 166 (1), pp.275-86.