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À propos

Mauro Gaya received his BSc degree in Molecular and Cellular Biology from the University of Buenos Aires in 2011 (Buenos Aires, Argentina). During his undergraduate studies, he worked at the Leloir Institute Foundation under the supervision of Dr. Silvia Moreno, investigating the role of dietary polyphenols on adipocyte differentiation.
Dr. Gaya obtained his PhD from the University College London in 2015 (London, UK). He performed his PhD work at the London Research Institute in the laboratory of Dr. Facundo Batista. While there, he uncovered a role for lymph node resident macrophages in the induction of B cell responses upon infection.
Dr. Gaya performed a joint postdoctoral stage in between the Francis Crick institute (London, UK) and the Ragon Institute of MGH, MIT and Harvard (Cambridge, Massachusetts, USA). His postdoctoral work led to seminal discoveries in the area of germinal centre biology.
Mauro Gaya was recruited to the CIML (Marseille, France) in 2018 to establish a research group focused on the analysis of B cell responses during pathogenic situations.

Main achievements

  • Elucidation of the role of Natural Killer T cells in the early seeding of germinal centre B cells during viral
    infection.
  • Demonstration that the disrupted organization of lymph node-resident macrophages induced by a primary
    infection temporarily shuts down immune responses to subsequent pathogens.

Publications

2026
Villazala-Merino S, Bertoia L, Fenouil R, Zghaebi M, Moussa M, Origlio S, Gregoire C, Almada L, Espo..., Germinal center interleukin-4 microniches drive tissue divergence of IgE memory B cell responses., Immunity 2026 Sep; (): .
2026
Gaya M, Gyrd-Hansen M, Kajaste-Rudnitski A, Iannacone M, Manel N, Pruneda JN, Rehwinkel J, van der V..., New frontiers in pathogen immunity., Nat Immunol 2026 Sep; (): .
2026
Marotta D, Perucchini C, Grillo M, Fumagalli V, Di Lucia P, Rixon J, Ravà M, Giustini L, Malpighi C..., Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection., Sci Immunol 2026 Aug; 11(122): eaec9853.
2026
Holgado MP, Origlio S, Bertoia L, Moussa M, Trivedi A, Fiore F, Zarubica A, Slack E, Linterman MA, C..., Mucosal tissue cues shape B cell memory through the IgA BCR., Sci Immunol 2026 Jul; 11(121): eadv1149.
2026
Gaya M, Good-Jacobson KL, Molecular and tissue regulation of memory B cells., Sci Immunol 2026 Jul; 11(121): eaef3415.
2025
Clemence Ngo, Camille Pierini-Malosse, Khalissa Rahmani, Michael Valente, Nils Collinet, Gilles Bess..., Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections, Nat Immunol 2025 Sep; (): .
2025
He C, Wang S, Moreews M, Pei S, Chen G, Li QZ, Del Monte Monge A, Ramiro AR, Cai C, Gaya M, Barral P..., The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses., Cell Rep 2025 May; 44(5): 115602.
2025
Almada L, Gazzoni YN, Beccaria CG, Fiocca Vernengo F, Boccardo S, Gorosito Serrán M, Trivedi A, Vin..., CD39 is an antibody-secreting B-cell marker that modulates germinal center and antibody responses during infection., Front Immunol 2025 ; 16(): 1547929.
2024
Clemence Ngo, Khalissa Rahmani, Michael Valente, Nils Collinet, Gilles Bessou, Manon Fabregue, Sarah..., Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections, 2024.
2023
Joachim A, Aussel R, Gélard L, Zhang F, Mori D, Grégoire C, Villazala Merino S, Gaya M, Liang Y, M..., Defective LAT signalosome pathology in mice mimics human IgG4-related disease at single-cell level., J Exp Med 2023 Nov; 220(11): .
2022
Ataide MA, Knöpper K, Cruz de Casas P, Ugur M, Eickhoff S, Zou M, Shaikh H, Trivedi A, Grafen A, Ya..., Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes., Immunity 2022 Oct; 55(10): 1813-1828.e9.
2022
Claude Gregoire, Lionel Spinelli, Sergio Villazala-Merino, Laurine Gil, María Pía Holgado, Myriam ..., Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism, Immunity 2022 Jul; 55(7): 1216-1233.e9.
2022
Courey-Ghaouzi A, Gaya M, Identification of Non-classical Follicular T Cells., Methods Mol Biol 2022 ; 2380(): 77-84.
2018
Tsui C, Martinez-Martin N, Gaya M, Maldonado P, Llorian M, Legrave NM, Rossi M, MacRae JI, Cameron A..., Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis., Immunity 2018 Jun; 48(6): 1144-1159.e5.
2018
Sáez de Guinoa J, Jimeno R, Gaya M, Kipling D, Garzón MJ, Dunn-Walters D, Ubeda C, Barral P, CD1d-mediated lipid presentation by CD11c+ cells regulates intestinal homeostasis., EMBO J 2018 Mar; 37(5): .
2018
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, Aid M, Tsui C, Maldonado P, Nai..., Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells., Cell 2018 Jan; 172(3): 517-533.e20.
2018
Burbage M, Gasparrini F, Aggarwal S, Gaya M, Arnold J, Nair U, Way M, Bruckbauer A, Batista FD, Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity., Elife 2018 Jan; 7(): .
2017
Martinez-Martin N, Maldonado P, Gasparrini F, Frederico B, Aggarwal S, Gaya M, Tsui C, Burbage M, Ke..., A switch from canonical to noncanonical autophagy shapes B cell responses., Science 2017 Feb; 355(6325): 641-647.
2015
Gaya M, Castello A, Montaner B, Rogers N, Reis e Sousa C, Bruckbauer A, Batista FD, Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection., Science 2015 Feb; 347(6222): 667-72.
2015
Burbage M, Keppler SJ, Gasparrini F, Martínez-Martín N, Gaya M, Feest C, Domart MC, Brakebusch C, ..., Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity., J Exp Med 2015 Jan; 212(1): 53-72.
2013
Castello A, Gaya M, Tucholski J, Oellerich T, Lu KH, Tafuri A, Pawson T, Wienands J, Engelke M, Bati..., Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells., Nat Immunol 2013 Sep; 14(9): 966-75.
2013
Gaya M, Repetto V, Toneatto J, Anesini C, Piwien-Pilipuk G, Moreno S, Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program., Biochim Biophys Acta 2013 Jun; 1830(6): 3796-806.