Publication: Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles.

Publié dans: Chem Commun (Camb) 2019 Dec; 55(100): 15121-15124

Auteurs: Peramo A, Dumas A, Remita H, Benoît M, Yen-Nicolay S, Corre R, Louzada RA, Dupuy C, Pecnard S, Lambert B, Young J, Desmaële D, Couvreur P

Résumé

We have developed new benign palladium nanoparticles able to catalyze the Suzuki-Miyaura cross-coupling reaction on human thyroglobulin (Tg), a naturally iodinated protein produced by the thyroid gland, in homogenates from patients’ tissues. This represents the first example of a chemoselective native protein modification using transition metal nanoobjects in near-organ medium.

Lien vers Pubmed [PMID] – 31782421

Lien vers le DOI – 10.1039/c9cc07803g