Publication: Protein synthesis regulation, a pillar of strength for innate immunity?

Publié dans: Curr Opin Immunol 2015 Feb; 32(): 28-35

Auteurs: Argüello RJ, Rodriguez Rodrigues C, Gatti E, Pierre P

Résumé

Recognition of pathogen derived molecules by Pattern Recognition Receptors (PRR) induces the production of cytokines (i.e. type I interferons) that stimulate the surrounding cells to transcribe and translate hundreds of genes, in order to prevent further infection and organize the immune response. Here, we report on the rising matter that metabolism sensing and gene expression control at the level of mRNA translation, allow swift responses that mobilize host defenses and coordinate innate responses to infection.

Lien vers Pubmed [PMID] – 25553394

Lien vers le DOI – 10.1016/j.coi.2014.12.001