Publication: Neuropilins, semaphorins, and their role in thymocyte development.

Publié dans: Ann N Y Acad Sci 2009 Feb; 1153(): 20-8

Auteurs: Mendes-da-Cruz DA, Lepelletier Y, Brignier AC, Smaniotto S, Renand A, Milpied P, Dardenne M, Hermine O, Savino W

Résumé

Some molecules described in the nervous system are also expressed in cells involved in the control of the immune response, suggesting they have a role as common mechanisms between neuroendocrine and immune systems. In this review, we focus on the expression and role of neuropilins (NPs) and their soluble ligands class 3 semaphorins in thymus physiology, particularly migration of developing thymocytes. We also discuss the concept of multivectorial thymocyte migration, including semaphorins, as a new individual cell migration vector.

Lien vers Pubmed [PMID] – 19236324

Lien vers le DOI – 10.1111/j.1749-6632.2008.03980.x