Publication: Human NK cell education by inhibitory receptors for MHC class I

Publié dans: Immunity, 2006, 25 (2), pp.331-42. ⟨10.1016/j.immuni.2006.06.013⟩

Auteurs: Nicolas Anfossi, Pascale André, Sophie Guia, Christine S Falk, Sophie Roetynck, C Andrew Stewart, Violette Breso, Coralie Frassati, Denis Reviron, Derek Middleton, François Romagné, Sophie Ugolini, Eric Vivier

Résumé

Natural killer (NK) cells recognize the absence of self MHC class I as a way to discriminate normal cells from cells in distress. In humans, this « missing self » recognition is ensured by inhibitory receptors such as KIR, which dampen NK cell activation upon interaction with their MHC class I ligands. We show here that NK cells lacking inhibitory KIR for self MHC class I molecules are present in human peripheral blood. These cells harbor a mature NK cell phenotype but are hyporesponsive to various stimuli, including MHC class I-deficient target cells. This response is in contrast to NK cells that express a single inhibitory KIR specific for self MHC class I, which are functionally competent when exposed to the same stimuli. These results show the involvement of KIR-MHC class I interactions in the calibration of NK cell effector capacities, suggesting its role in the subsequent « missing self » recognition.

Lien vers Pubmed [PMID] – 16901727

Lien vers HAL – hal-00165596

Lien vers le DOI – 10.1016/j.immuni.2006.06.013