Publication: Extreme multifunctional proteins identified from a human protein interaction network.

Publié dans: Nature Communications, 2015, 6 (1), pp.7412. ⟨10.1038/ncomms8412⟩

Auteurs: Charles E Chapple, Benoît Robisson, Lionel Spinelli, Celine Guien, Becker Emmanuelle, Christine Brun

Résumé

Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of ‘extreme multifunctional’ proteins from an interactome as a first step to characterize moonlighting proteins. By combining network topological information with protein annotations, we identify 430 extreme multifunctional proteins (3% of the human interactome). We show that the candidates form a distinct subgroup of proteins, characterized by specific features, which form a signature of extreme multi-functionality. Overall, extreme multifunctional proteins are enriched in linear motifs and less intrinsically disordered than network hubs. We also provide MoonDB, a database containing information on all the candidates identified in the analysis and a set of manually curated human moonlighting proteins.

Lien vers Pubmed [PMID] – 26054620

Lien vers HAL – amu-01769932

Lien vers le DOI – 10.1038/ncomms8412