Publication: Behavioral characterization of CD26 deficient mice in animal tests of anxiety and antidepressant-like activity.

Publié dans: Behavioural Brain Research, 2006, 171 (2), pp.279-85. ⟨10.1016/j.bbr.2006.04.003⟩

Auteurs: Malika El Yacoubi, Jean-Marie Vaugeois, Didier Marguet, Nicole Sauze, Régis Guieu, Jean Costentin, Emmanuel Fenouillet

Résumé

CD26 exhibits a dipeptidylpeptidase-IV function (DPPIV) which regulates neuropeptide activity by N-terminal processing. Because abnormal plasma DPPIV was associated in mammals with behavioral changes, we examined the behavior of CD26-/- mice resulting from targeted inactivation of the gene. These animals had a decreased immobility in the forced swim and tail suspension tests, indicating a reduced depression-like behavior. We addressed some factors that could affect these results. No major differences between mutants and controls were observed in the black/white box test that investigates anxiety. In the hole-board apparatus that explores both curiosity and anxiety, CD26-/- mice of both genders made significantly more head dips than controls. In a motor activity test, mutants displayed higher horizontal and vertical activities i.e. increased novelty-induced behavioral activation. We conclude that DPPIV inactivation in mice broadly leads to an antidepressant-like and hyperactive phenotype.

Lien vers HAL – hal-00135369

Lien vers le DOI – 10.1016/j.bbr.2006.04.003